Abstract
Vocal fold paralysis is a pathological finding of motion impairment of varying degrees caused by nervous system disorders. In this chapter, the detailed anatomy of the laryngeal nerves and their varying anastomotic patterns within the larynx are described. Regeneration of nerve fibers after damage varies among patients. Significant misdirected regeneration occurs in some, whereas others show little synkinesis, which is a major cause of considerable inconsistencies of the vibratory pattern of the vocal folds among patients with unilateral vocal fold paralysis. Second, the effects of changes in the physical properties of the affected vocal fold on the production of the mucosal wave are summarized. Third, the factors that must be considered before surgical treatment of paralytic dysphonia are highlighted. Finally, reacquisition of the thyroarytenoid muscle tonus by reinnervation is important in recovering the preinjury voice with a dynamic mucosal wave.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
“Paralysis” means loss or impairment of motor function due in part to a lesion of the neural or muscular mechanism (cited from Dorland’s illustrated Medical Dictionary).
- 2.
The activities of the cricothyroid muscle are assumed to be responsible for the preponderance of the median position among paralyzed vocal fold positions [22].
References
Vogel PH. The innervations of the larynx of man and the dog. Am J Anat. 1952;90:427–47.
Sanudo JR, Maranillo E, Leon X, Mirapeix RM, Orus C, Quer M. An anatomical study of anastomoses between the laryngeal nerves. Laryngoscope. 1999;109:983–7.
Boles R, Fritzell B. Injury and repair of the recurrent laryngeal nerves in dogs. Laryngoscope. 1969;79:1405–18.
Shindo ML, Herzon GD, Hanson DG, Cain DJ, Sahgal V. Effects of denervation on laryngeal muscles: a canine model. Laryngoscope. 1992;102:663–9.
Woodson GE. Spontaneous laryngeal reinnervation after recurrent laryngeal or vagus nerve injury. Ann Otol Rhinol Laryngol. 2007;116:57–65.
Woodson G. Configuration of the glottis in laryngeal paralysis. II: animal experiments. Laryngoscope. 1993;103:1235–41.
Aronson AE, DeSanto LW. Adductor spastic dysphonia: three years after recurrent laryngeal nerve resection. Laryngoscope. 1983;93:1–8.
Schratzki H, Fritzell B. Treatment of spasmodic dysphonia by means of resection of the recurrent laryngeal nerve. Acta Otolaryngol. 1988;449:115–7.
Netterville JL, Stone RE, Rainey C, Zealear DL, Ossoff RH. Recurrent laryngeal nerve avulsion for treatment of spatic dysphonia. Ann Otol Rhinol Laryngol. 1991;100:10–4.
Crumley RL. Unilateral recurrent laryngeal nerve paralysis. J Voice. 1994;1:70–83.
Koufman JA, Walker FO, Joharji GM. The cricothyroid muscle does not influence vocal fold position in laryngeal paralysis. Laryngoscope. 1995;105:368–72.
Nomoto M, Yoshihara T, Kanda T, Kaneko T. Synapse formation by autonomic nerves in the previously denervated neuromuscular junctions of the feline intrinsic laryngeal muscles. Brain Res. 1991;539:276–86.
Nomoto M, Yoshihara T, Kanda T, Konno A, Kaneko T. Misdirected reinnervation in the feline intrinsic laryngeal muscles after long-term denervation. Acta Otolaryngol Suppl. 1993;506:71–4.
Sanders I, Wu B, Mu L, Li Y, Biller HF. The innervations of the human larynx. Arch Otolaryngol Head Neck Surg. 1993;119:934–9.
Wu BL, Sanders I, Mu L, Biller HF. The human communicating nerve. An extension of the external superior laryngeal nerve that innervates the vocal cord. Arch Otolaryngol Head Neck Surg. 1994;120:1321–8.
Crumley RC. Laryngeal synkinesis revisited. Ann Otol Rhinol Laryngol. 2000;109:365–71.
Gacek RR. Morphologic correlates for laryngeal reinnervation. Laryngoscope. 2001;111:1871–7.
Maranillo E, Vazquez T, Quer M, Niedenfuhr MR, Leon X, Viejo F, Parkin I, Sanudo JR. Potential structures that could be confused with a nonrecurrent inferior laryngeal nerve: an anatomical study. Laryngoscope. 2008;118:56–60.
Nasri S, Beizai P, Ye M, Sercarz JA, Kim YM, Berke GS. Cross-innervation of the thyroarytenoid muscle by a branch from the external division of the superior laryngeal nerve. Ann Otol Rhinol Laryngol. 1997;106:594–8.
Semon F. Clinical remarks. On the proclivity of the abductor fibers of the recurrent laryngeal nerve to become affected sooner than the adductor fibers or even exclusively; in cases of undoubted central or peripheral injury or disease of the roots or trunks of the pneumogastric, spinal accessory or recurrent nerves. Arch Laryngol. 1881;2:197–222.
Faaborg-Andersen K. The position of paretic vocal cords. Acta Otolaryngol. 1964;57:50–4.
Grossman M. Contribution to the mutural functional relationships of the muscles of the larynx. Arch Laryngol Rhinol. 1906;18:463–71.
Woodson GE. Configuration of the glottis in laryngeal paralysis. I: clinical study. Laryngoscope. 1993;103:1227–34.
Blitzer A, Jahn AF, Keider A. Semon’s law revisited: an electromyographic analysis of laryngeal synkinesis. Ann Otol Rhinol Laryngol. 1996;105:764–9.
Maranillo E, Leon X, Orus C, Quer M, Sanudo JR. Variability in nerve patterns of the adductor muscle group supplied by the recurrent laryngeal nerve. Laryngoscope. 2005;115:358–62.
Brown MC, Holland RL, Hopkins WG. Motor nerve sprouting. Ann Rev Neurosci. 1981;4:17–42.
Damrose EJ, Huang RY, Blumin JH, Blackwell KE, Sercarz JA, Berke GS. Lack of evoked laryngeal electromyography response in patients with a clinical diagnosis of vocal cord paralysis. Ann Otol Rhinol Laryngol. 2001;110:815–9.
Siribodhi C, Sunderland W, Atkins JP, Bonner FJ. Electromyographic studies of laryngeal paralysis and regeneration of laryngeal motor nerves in dogs. Laryngoscope. 1963;73:148–63.
Hiroto I, Hirano M, Tomita H. Electromyographic investigations of human vocal cord paralysis. Ann Otol Rhinol Laryngol. 1968;77:296–304.
Tashiro T. Experimental studies of the reinnervation of larynx after accurate neurorrhaphy. Laryngoscope. 1972;82:225–36.
Ohyama M, Ueda N, Harvey JE, Mogi G, Ogura JH. Electrophysiologic study of reinnervated laryngeal motor units. Laryngoscope. 1972;82:237–51.
Satoh I, Harvey JH, Ogura JH. Impairment of function of the intrinsic laryngeal muscles after regeneration of the recurrent laryngeal nerve. Laryngoscope. 1974;84:53–66.
Crumley RL. Laryngeal synkinesis: its significance to the laryngologists. Ann Otol Rhinol Laryngol. 1989;98:87–92.
Flint PW, Downs DH, Coltrera MD. Laryngeal synkinesis following reinnervation in the rat: neuroanatomic and physiologic study using retrograde fluorescent tracers and electromyography. Ann Otol Rhinol Laryngol. 1991;100:797–806.
Nahm I, Shin T, Watanabe H, Maeyama T. Misdirected regeneration of injured recurrent laryngeal nerve in the cat. Am J Otolaryngol. 1993;14:43–8.
Min YB, Finnegan EM, Hoffman HT, Luschei ES, McCulloch TM. A preliminary study of the prognostic role of electromyography in laryngeal paralysis. Otolaryngol Head Neck Surg. 1994;111:770–5.
Wani MK, Woodson GE. Paroxysmal laryngospasm after laryngeal nerve injury. Laryngoscope. 1999;109:694–7.
Diamond J, Cooper E, Turner C, Macintyre L. Trophic regulation of nerve sprouting. Science. 1976;193:371–7.
Sunderland S, Swaney WE. The intraneural topography of the recurrent laryngeal nerve in man. Anat Rec. 1952;114:411–26.
Gacek RR, Malmgren LT, Lyon MJ. Localization of adductor and abductor motor nerve fibers to the larynx. Ann Otol Rhinol Laryngol. 1977;86:770–6.
Malmgren LT, Gacek RR. Acetylcholineesterase staining of fiber components in feline and human recurrent laryngeal nerve: topography of laryngeal motor fiber regions. Acta Otolaryngol. 1981;91:337–52.
Hisa Y, Koike S, Tadaki N, Bamba H, Shogaki K, Uno T. Neurotransmitters and neuromodulators involved in laryngeal innervation. Ann Otol Rhinol Laryngol. 1999;108:3–14.
Gordon JH, McCabe BF. The effect of accurate neurorrhaphy on reinnervation and return of laryngeal function. Laryngoscope. 1968;78:236–50.
Morledge DR, Lauvstad WA, Calcaterra TC. Delayed reinnervation of the paralyzed larynx. An experimental study in the dog. Arch Otolaryngol. 1973;37:291–3.
Eibling DE, Gross RD. Subglottic air pressure: a key component of swallowing efficiency. Ann Otol Rhinol Laryngol. 1996;105:253–8.
Carrau RL, Pou A, Eibling DE, Murry T. Laryngeal framework surgery for the management of aspiration. Head Neck. 1999;21:139–45.
Tabaee A, Murry T, Zschommler A, Desloge RB. Flexible endoscopic evaluation of swallowing with sensory testing in patients with unilateral vocal fold immobility: incidence and pathophysiology of aspiration. Laryngoscope. 2005;115:565–9.
Heitmiller RF, Tseng E, Jones B. Prevalence of aspiration and laryngeal penetration in patients with unilateral vocal fold motion impairment. Dysphagia. 2000;15:184–7.
Bhattacharyya N, Kotz T, Shapiro J. Dysphagia and aspiration with unilateral vocal cord immobility: incidence, characterization and response to surgical treatment. Ann Otol Rhinol Laryngol. 2002;111:672–9.
Smith E, Taylor M, Mendoza M, Barkmeier J, Lemke J, Hoffman H. Spasmodic dysphonia and vocal fold paralysis: outcomes of voice problems on work-related functioning. J Voice. 1998;12:223–32.
Benninger MS, Ahuja AS, Gardner G, Grywalski C. Assessing outcomes for dysphonic patients. J Voice. 1998;12:540–50.
Baba M, Natsugoe S, Shimada M, Nakano S, Noguchi Y, Kawachi K, Kusano C, Aikou T. Does hoarseness of voice from recurrent nerve paralysis after esophagectomy for carcinoma influence patient quality of life? J Am Coll Surg. 1999;188:231–6.
Fang TJ, Li HY, Glicklich RE, Chen YH, Wang PC, Chuang HF. Quality of life measures and predictors for adults with unilateral vocal cord paralysis. Laryngoscope. 2008;118:1837–41.
Isshiki N. Vocal efficiency index. In: Stevens KN, Hirano M, editors. Vocal fold physiology. Tokyo: University of Tokyo Press; 1981. p. 193–207.
Hirano M. Clinical examination of voice. Wien: Springer; 1981.
Lucero JC. Optimal glottal configuration for ease of phonation. J Voice. 1998;12:151–8.
Kobayashi J, Yumoto E, Hyodo M, Gyo K. Two-dimensional analysis of vocal fold vibration in unilaterally atrophied larynges. Laryngoscope. 2000;110:440–6.
Hirano M. Morphological structure of the vocal cord as a vibrator and its variations. Folia Phoniatr. 1974;26:89–94.
Yumoto E, Kadota Y, Kurokawa H. Thyroarytenoid muscle activity and infraglottic aspect of canine vocal fold vibration. Arch Otolaryngol Head Neck Surg. 1995;121:759–64.
Yanagi E, Slavit DH, McCaffrey TV. Study of phonation in the excised canine larynx. Otolaryngol Head Neck Surg. 1991;105:586–95.
Choi HS, Berke GS, Ye M, Kreiman J. Function of the thyroarytenoid muscle in a canine laryngeal model. Ann Otol Rhinol Laryngol. 1993;102:769–76.
Sloan SH, Berke GS, Gerratt BR, Kreiman J, Ye M. Determination of vocal fold mucosal wave velocity in an in vivo canine model. Laryngoscope. 1993;103:947–53.
Yumoto E, Kadota Y. Quantitative evaluation of the effects of thyroarytenoid muscle activity upon pliability of vocal fold mucosa in an in vivo canine model. Laryngoscope. 1997;107:266–72.
Sercarz JA, Berke GS, Ming YM, Gerratt BR, Natividad MN. Videostroboscopy of human vocal fold paralysis. Ann Otol Rhinol Laryngol. 1992;101:567–77.
Tanabe M, Isshiki N, Kitajima K. Vibratory pattern of the vocal cord in unilateral paralysis of the cricothyroid muscle. An experimental study. Acta Otolaryngol. 1972;74:339–45.
Isshiki N, Tanabe M, Ishizaka K, Broad D. Clinical significance of asymmetrical vocal cord tension. Ann Otol Rhinol Laryngol. 1977;86:58–66.
Maunsell R, Ouaknine M, Giovanni A, Crespo A. Vibratory pattern of vocal folds under tension asymmetry. Otolaryngol Head Neck Surg. 2006;135:438–44.
Yumoto E, Kurokawa H, Okamura H. Vocal fold vibration of the canine larynx: observation from an infraglottic view. J Voice. 1991;5:299–303.
Yumoto E, Kadota Y, Kurokawa H. Tracheal view of vocal fold vibration in excised canine larynx. Arch Otolaryngol Head Neck Surg. 1993;119:73–8.
Yumoto E, Kadota Y, Kurokawa H. Infraglottic aspect of canine vocal fold vibration: effect of increase of mean airflow rate and lengthening of vocal fold. J Voice. 1993;7:311–8.
Yumoto E, Kadota Y, Kurokawa H, Sasaki Y. Effects of vocal fold tension and thyroarytenoid activity on the infraglottic aspect of vocal fold vibration and glottal source sound quality. In: Fujimura O, Hirano M, editors. Vocal fold physiology: voice quality control. San Diego: Singular Publishing Group; 1995. p. 127–45.
Yumoto E, Kadota Y. Pliability of the vocal fold mucosa in relation to the mucosal upheaval during phonation. Arch Otolaryngol Head Neck Surg. 1998;124:897–902.
Hirano M, Yoshida T, Tanaka S. Vibratory behavior of human vocal folds viewed from below. In: Gauffin J, Hammarberg B, editors. Vocal fold physiology. Acoustic, perceptual, and physiological aspects of voice mechanism. San Diego: Singular Publishing Group; 1991. p. 1–6.
Yumoto E, Kadota Y, Mori T. Vocal fold vibration viewed from the tracheal side in living human beings. Otolaryngol Head Neck Surg. 1996;115:329–34.
Sanders I, Rai S, Han Y, Biller HF. Human vocalis contains distinct superior and inferior subcompartments: possible candidates for the two masses of vocal fold vibration. Ann Otol Rhinol Laryngol. 1998;107:826–33.
Sanders I, Han Y, Wang J, Biller H. Muscle spindles are concentrated in the superior vocalis subcompartment of the human thyroarytenoid muscle. J Voice. 1998;12:7–16.
Gray SD, Bielamowicz SA, Titze IR, Dove H, Ludlow C. Experimental approaches to vocal fold alteration: introduction to the minithyrotomy. Ann Otol Rhinol Laryngol. 1999;108:1–9.
Isshiki N, Ishikawa T. Diagnostic value of tomography in unilateral vocal cord paralysis. Laryngoscope. 1976;86:1573–8.
Yamada M, Hirano M. Recurrent laryngeal nerve paralysis. A 10-year review of 564 patients. Auris Nasus Larynx. 1983;10(Suppl):1–15.
Hirano M. Phonosurgery. Basic and clinical investigations. Otologia (Fukuoka). 1975;21:239–442.
Yumoto E, Nakano K, Oyamada Y. Relationship between 3D behavior of the unilaterally paralyzed larynx and aerodynamic vocal function. Acta Otolaryngol. 2003;123:274–8.
Yumoto E, Sanuki T, Minoda R, Kumai Y, Nishimoto K, Kodama N. Over-adduction of the unaffected vocal fold during phonation in the unilaterally paralyzed larynx. Acta Otolaryngol. 2014;134:744–52.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Japan
About this chapter
Cite this chapter
Yumoto, E. (2015). Basic Knowledge of Vocal Fold Paralysis. In: Pathophysiology and Surgical Treatment of Unilateral Vocal Fold Paralysis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55354-0_1
Download citation
DOI: https://doi.org/10.1007/978-4-431-55354-0_1
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-55353-3
Online ISBN: 978-4-431-55354-0
eBook Packages: MedicineMedicine (R0)