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Nano/Micro Science and Technology in Biorheology pp 261–294Cite as

Biomedical Application of Soft Nano-/Microparticles

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Abstract

In recent years, the soft hydrogel nano-/microparticles have been investigated intensively. Their great porosity, elasticity, and biocompatibility benefit their application, especially in the biomedical field as drug delivery system. Proteins, peptides, or other bioactive molecules can be entrapped inside of these particles with less bioactivity loss and released slowly through the pores of hydrogel. After modifying with targeting molecules or using stimuli-responsive materials, these particles can deliver entrapped drugs to targeting tissues or cells. Recently, hydrogel nano-/microparticles have also been proposed as vaccine adjuvant. The introduction of hydrogel particles in vaccine formulations not only protects the bioactivity of antigens but also increases the immune response. However, due to the high viscosity and water content and weak mechanical strength of hydrogel, there exist many difficulties in preparation and characterization of hydrogel particles. In order to conquer these problems, several novel techniques have been promoted, which are introduced in this review. After reviewing the development of preparation and characterization of hydrogel nano-/microparticles, the application study of these particles on drug delivery systems and on vaccine adjuvants is summarized.

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Authors and Affiliations

  1. National Key Lab of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, People’s Republic of China

    Jie Wu, Xi Zhao, Yue-Qi Wang & Guang-Hui Ma

  2. University of Chinese Academy of Sciences, Beijing, 100190, People’s Republic of China

    Xi Zhao & Yue-Qi Wang

Authors
  1. Jie Wu
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  2. Xi Zhao
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  3. Yue-Qi Wang
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  4. Guang-Hui Ma
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Corresponding author

Correspondence to Guang-Hui Ma .

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Editors and Affiliations

  1. Department of Physics, Tokai University, Hiratsuka, Kanagawa, Japan

    Rio Kita

  2. Division of Molecular Science, Faculty of Science and Technology, Gunma University, Kiryu, Gunma, Japan

    Toshiaki Dobashi

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Wu, J., Zhao, X., Wang, YQ., Ma, GH. (2015). Biomedical Application of Soft Nano-/Microparticles. In: Kita, R., Dobashi, T. (eds) Nano/Micro Science and Technology in Biorheology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54886-7_11

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