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Odor Maps in the Olfactory Bulb

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Book cover The Olfactory System

Abstract

The olfactory bulb is the first relay station of the central olfactory system in the mammalian brain and contains a few thousand glomeruli on its surface. Individual glomeruli represent a single type of odorant receptor, and the glomerular sheet of the olfactory bulb forms odorant receptor maps. This chapter summarizes the spatial organization of the odorant receptor-representing glomerular maps of the rodent olfactory bulb, focusing on (1) the domain organization of each glomerular map, (2) “intrabulbar projections” of tufted cell axons that precisely and topographically connect the lateral and medial maps, (3) molecular feature clusters of glomeruli in the olfactory bulb, and (4) functional compartmentalization of the glomerular maps.

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References

  • Amoore JE, Johnston JW Jr, Rubin M (1964) The sterochemical theory of odor. Sci Am 210:42–49

    Article  CAS  PubMed  Google Scholar 

  • Astic L, Saucier D (1986) Anatomical mapping of the neuroepithelial projection to the olfactory bulb in the rat. Brain Res Bull 16:445–454

    Article  CAS  PubMed  Google Scholar 

  • Bader A, Klein B, Breer H, Strotmann J (2012) Connectivity from OR37 expressing olfactory sensory neurons to distinct cell types in the hypothalamus. Front Neural Circuits 6:84

    Article  PubMed Central  PubMed  Google Scholar 

  • Beets MG (1970) The molecular parameters of olfactory response. Pharmacol Rev 22:1–34

    CAS  PubMed  Google Scholar 

  • Belluscio L, Lodovichi C, Feinstein P, Mombaerts P, Katz LC (2002) Odorant receptors instruct functional circuitry in the mouse olfactory bulb. Nature (Lond) 419:296–300

    Article  CAS  Google Scholar 

  • Bozza T, Vassalli A, Fuss S, Zhang J, Weiland B et al (2009) Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse. Neuron 61:220–233

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cummings DM, Belluscio L (2008) Charting plasticity in the regenerating maps of the mammalian olfactory bulb. Neuroscientist 14:251–263

    PubMed Central  PubMed  Google Scholar 

  • Cummings DM, Belluscio L (2010) Continuous neural plasticity in the olfactory intrabulbar circuitry. J Neurosci 30:9172–9180

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dielenberg RA, McGregor IS (2001) Defensive behavior in rats towards predatory odors: a review. Neurosci Biobehav Rev 25:597–609

    Article  CAS  PubMed  Google Scholar 

  • Hebb AL, Zacharko RM, Dominguez H, Trudel F, Laforest S, Drolet G (2002) Odor-induced variation in anxiety-like behavior in mice is associated with discrete and differential effects on mesocorticolimbic cholecystokinin mRNA expression. Neuropsychopharmacology 27:744–755

    Article  CAS  PubMed  Google Scholar 

  • Hebb AL, Zacharko RM, Gauthier M, Trudel F, Laforest S, Drolet G (2004) Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice. Eur J Neurosci 20:2415–2429

    Article  PubMed  Google Scholar 

  • Igarashi K, Mori K (2005) Spatial representation of hydrocarbon odorants in the ventrolateral zones of the rat olfactory bulb. J Neurophysiol 93:1007–1019

    Article  CAS  PubMed  Google Scholar 

  • Igarashi KM, Ieki N, An M, Yamaguchi Y, Nagayama S et al (2012) Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex. J Neurosci 32:7970–7985

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Imai T, Sakano H (2007) Roles of odorant receptors in projecting axons in the mouse olfactory system. Curr Opin Neurobiol 17:507–515

    Article  CAS  PubMed  Google Scholar 

  • Johnson B, Leon M (2007) Chemotopic odorant coding in a mammalian olfactory system. J Comp Neurol 503:1–34

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Johnson B, Xu Z, Ali S, Leon M (2009) Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization. J Comp Neurol 514:658–673

    Article  CAS  PubMed  Google Scholar 

  • Kikuta S, Fletcher ML, Homma R, Yamasoba T, Nagayama S (2013) Odorant response properties of individual neurons in an olfactory glomerular module. Neuron 77:1122–1135

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T et al (2007) Innate versus learned odour processing in the mouse olfactory bulb. Nature (Lond) 450:503–508

    Article  CAS  Google Scholar 

  • Liberles SD, Buck LB (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature (Lond) 442:645–650

    Article  CAS  Google Scholar 

  • Liu WL, Shipley MT (1994) Intrabulbar associational system in the rat olfactory bulb comprises cholecystokinin-containing tufted cells that synapse onto the dendrites of GABAergic granule cells. J Comp Neurol 346:541–558

    Article  CAS  PubMed  Google Scholar 

  • Lodovichi C, Belluscio L, Katz LC (2003) Functional topography of connections linking mirror-symmetric maps in the mouse olfactory bulb. Neuron 38:265–276

    Article  CAS  PubMed  Google Scholar 

  • Marks CA, Cheng K, Cummings DM, Belluscio L (2006) Activity-dependent plasticity in the olfactory intrabulbar map. J Neurosci 26:11257–11266

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto H, Kobayakawa K, Kobayakawa R, Tashiro T, Mori K, Sakano H (2010) Spatial arrangement of glomerular molecular-feature clusters in the odorant-receptor class domains of the mouse olfactory bulb. J Neurophysiol 103:3490–3500

    Article  CAS  PubMed  Google Scholar 

  • Migliore M, Hines ML, McTavish TS, Shepherd GM (2010) Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb. Front Integr Neurosci 4:122

    Article  PubMed Central  PubMed  Google Scholar 

  • Mombaerts P (2006) Axonal wiring in the mouse olfactory system. Annu Rev Cell Dev Biol 22:713–737

    Article  CAS  PubMed  Google Scholar 

  • Mombaerts P, Wang F, Dulac C, Chao SK, Nemes A et al (1996) Visualizing an olfactory sensory map. Cell 87:675–686

    Article  CAS  PubMed  Google Scholar 

  • Moncrieff RW (1967) The chemical senses. Leonard Hill, London

    Google Scholar 

  • Mori K (1987) Membrane and synaptic properties of identified neurons in the olfactory bulb. Prog Neurobiol 29:275–320

    Article  CAS  PubMed  Google Scholar 

  • Mori K, Sakano H (2011) How is the olfactory map formed and interpreted in the mammalian brain? Annu Rev Neurosci 34:467–499

    Article  CAS  PubMed  Google Scholar 

  • Mori K, Takahashi Y, Igarashi K, Yamaguchi M (2006) Maps of odorant molecular features in the mammalian olfactory bulb. Physiol Rev 86:409–433

    Article  CAS  PubMed  Google Scholar 

  • Nagao H, Yoshihara Y, Mitsui S, Fujisawa H, Mori K (2000) Two mirror-image sensory maps with domain organization in the mouse main olfactory bulb. Neuroreport 11:3023–3027

    Article  CAS  PubMed  Google Scholar 

  • Pacifico R, Dewan A, Cawley D, Guo C, Bozza T (2012) An olfactory subsystem that mediates high-sensitivity detection of volatile amines. Cell Rep 2:76–88

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ressler KJ, Sullivan SL, Buck LB (1994) Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79:1245–1255

    Article  CAS  PubMed  Google Scholar 

  • Rossiter KJ (1996) Structure–odor relationships. Chem Rev 96:3201–3240

    Article  CAS  PubMed  Google Scholar 

  • Saucier D, Astic L (1986) Analysis of the topographical organization of olfactory epithelium projections in the rat. Brain Res Bull 16:455–462

    Article  CAS  PubMed  Google Scholar 

  • Schoenfeld TA, Macrides F (1984) Topographic organization of connections between the main olfactory bulb and pars externa of the anterior olfactory nucleus in the hamster. J Comp Neurol 227:121–135

    Article  CAS  PubMed  Google Scholar 

  • Schoenfeld TA, Marchand JE, Macrides F (1985) Topographic organization of tufted cell axonal projections in the hamster main olfactory bulb: an intrabulbar associational system. J Comp Neurol 235:503–518

    Article  CAS  PubMed  Google Scholar 

  • Schoenfeld TA, Clancy AN, Forbes WB, Macrides F (1994) The spatial organization of the peripheral olfactory system of the hamster. Part I: receptor neuron projections to the main olfactory bulb. Brain Res Bull 34:183–210

    Article  CAS  PubMed  Google Scholar 

  • Shepherd G, Chen WR, Greer CA (eds) (2004) Olfactory bulb. Oxford University Press, New York, pp 165–216

    Google Scholar 

  • Takahashi Y, Kurosaki M, Hirono S, Mori K (2004) Topographic representation of odorant molecular features in the rat olfactory bulb. J Neurophysiol 92:2413–2427

    Article  CAS  PubMed  Google Scholar 

  • Takeuchi H, Inokuchi K, Aoki M, Suto F, Tsuboi A et al (2010) Sequential arrival and graded secretion of Sema3F by olfactory neuron axons specify map topography at the bulb. Cell 141:1056–1067

    Article  CAS  PubMed  Google Scholar 

  • Tsuboi A, Miyazaki T, Imai T, Sakano H (2006) Olfactory sensory neurons expressing class I odorant receptors converge their axons on an antero-dorsal domain of the olfactory bulb in the mouse. Eur J Neurosci 23:1436–1444

    Article  PubMed  Google Scholar 

  • Vassar R, Chao SK, Sitcheran R, Nunez JM, Vosshall LB, Axel R (1994) Topographic organization of sensory projections to the olfactory bulb. Cell 79:981–991

    Article  CAS  PubMed  Google Scholar 

  • Willhite DC, Nguyen KT, Masurkar AV, Greer CA, Shepherd GM, Chen WR (2006) Viral tracing identifies distributed columnar organization in the olfactory bulb. Proc Natl Acad Sci USA 103:12592–12597

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Yan Z, Tan J, Qin C, Lu Y, Ding C, Luo M (2008) Precise circuitry links bilaterally symmetric olfactory maps. Neuron 58:613–624

    Article  CAS  PubMed  Google Scholar 

  • Yoshihara Y, Kawasaki M, Tamada A, Fujita H, Hayashi H et al (1997) OCAM: A new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons. J Neurosci 17:5830–5842

    CAS  PubMed  Google Scholar 

  • Zhang X, Firestein S (2002) The olfactory receptor gene superfamily of the mouse. Nat Neurosci 5:124–133

    CAS  PubMed  Google Scholar 

  • Zhou Z, Belluscio L (2008) Intrabulbar projecting external tufted cells mediate a timing-based mechanism that dynamically gates olfactory bulb output. J Neurosci 28:9920–9928

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 118-0033, Japan

    Kensaku Mori

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  1. Kensaku Mori
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Correspondence to Kensaku Mori .

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  1. Department of Physiology, The University of Tokyo, Tokyo, Japan

    Kensaku Mori

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Mori, K. (2014). Odor Maps in the Olfactory Bulb. In: Mori, K. (eds) The Olfactory System. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54376-3_4

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