Skip to main content
SpringerLink
Log in

Brain Mapping in Thinking and Language Function

  • Conference paper
Language and Speech

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 56))

Summary

Regional cerebral blood flow, rCBF, is coupled to regional cerebral metabolism and changes in rCBF reflects changes in neuronal activity. rCBF studies have provided information about the functions of a great number of cortical regions in the normal human brain. Outside the motor areas and sensory association areas there are areas committed to the transformation of information retrieved or generated within the brain itself. Language is processed within these regions. In contrast to the general clinical impression the functional mapping methods reveal that there is a large number of cortical regions activated bilaterally during language processing. Pure intrinsic brain work causes a profound activation of the cerebral cortex. Different types of thinking are seen to activate different sectors of the cortical space.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Andersen AR, Friberg HH, Schmidt JF, Hasselbalch SG (1988) Quantitative measurements of cerebral blood flow using SPECT and 99 m-Tc-d, IHM-PAO compared to Xenon-313. J Cereb Blood Flow Metab 8: 69–81

    Article  Google Scholar 

  2. Broca PP (1861) Remarques sur le siège de la faculté du language articulé. Bull Soc d’antropol 33: 330–336

    Google Scholar 

  3. Celsis P, Goldman T, Henriksen L, Lassen NA (1981) A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations. J Comput Assist Tomogr 5: 641–645

    Article  PubMed  CAS  Google Scholar 

  4. English RE, Holman L (1987) Current status of cerebral perfusion radiopharmaceuticals. J Nucl Med Technol 15: 30

    Google Scholar 

  5. Fick A (1870) Über die Messung des Blutquantums in den Herzventrikeln. Ver Phys Med Ges Würzburg 2: 16

    Google Scholar 

  6. Friberg L, Skyhøjolsen T, Roland PE, Paulson OB, Lassen NA (1985) Focal increase of blood flow in the cerebral cortex of man during vestibular stimulation. Brain 108: 609–623

    Article  PubMed  Google Scholar 

  7. Friberg L, Roland PE (1988) Functional activation and inhibition of regional cerebral blood flow and metabolism. In: Olesen J, Edvinsson L (eds) Basic mechanisms of headache. Elsevir, pp. 89–98

    Google Scholar 

  8. Friberg L, Lassen NA (1991) Language and the cerebral hemispheres: Impact of stimulus relevance and absence of lateralized activation response as revealed by rCBF studies. In: Lassen NA, Ingvar DH, Raichle ME, Friberg L (eds). Brain Work and Mental Activity. Munksgaard, Copenhagen-Chicago-Tokyo, pp 294–308

    Google Scholar 

  9. Fulton JF (1928) Observations upon vascularity of the human occipital lobe during visual activity. Brain 51: 310–320

    Article  Google Scholar 

  10. Ginsberg MD, Howard BE, Hassel WR (1984) Emission tomography measurement of local cerebral blood flow in humans by an in vivo autoradiographic strategy. Ann Neurol 15 [Suppl]: 12–18

    Article  Google Scholar 

  11. Holm S, Madsen PL, Rubin P, Sperling B, Friberg L, Lassen NA (1991) Tc-99m-HMPAO activation studies: Validation of split-lose, image subtraction approach. J Cereb Blood Flow Metab 11 (Suppl. 2): 5766

    Google Scholar 

  12. Ingvar DH (1983) Serial aspects of language and speech related to prefrontal cortical activity. Human Neurobiology 2: 177–189

    PubMed  CAS  Google Scholar 

  13. Ingvar DH, Risberg J (1967) Increase of regional cerebral blood flow during mental effort in normals and in patients with focal brain disorders. Exp Brain Res 3: 195–211

    Article  PubMed  CAS  Google Scholar 

  14. Ingvar DH, Schwartz MS (1974) Blood flow patterns induced in the dominant hemisphere by speech and reading. Brain 97: 273288

    Google Scholar 

  15. Jaszczak RJ, Coleman RE (1988) Instrumentation for single-photon computed tomography studies of the brain. Am J Physiol Imaging 3: 67

    PubMed  CAS  Google Scholar 

  16. Kety SS (1950) Circulation and metabolism of the human brain in health and disease. Am J Med 8: 205–217

    Article  PubMed  CAS  Google Scholar 

  17. Kety SS, Schmidt CFS (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man. Theory, procedure and normal values. J Clin Invest 27: 476–483

    Google Scholar 

  18. Larsen B, Skinh¢j E, Lassen NA (1978) Variations in regional cortical blood flow in the right and left hemispheres during automatic speech. Brain 101: 193–209

    CAS  Google Scholar 

  19. Lassen NA, Ingvar DH (1961) The blood flow of the cerebral cortex determined by radioactive Crypton-85. Experienta 17: 42–43

    CAS  Google Scholar 

  20. Lassen NA, Ingvar DH (1963) Regional cerebral blood flow measurements in man. Arch Neurol Psychiat 9: 615–622

    Article  Google Scholar 

  21. Lassen NA, Ingvar DH, Raichle ME, Friberg L (1991) Brain Work and Mental Activity. Quantitative studies with radioactive tracers. Munksgaard, Copenhagen-Chicago-Tokyo, pp 1–445

    Google Scholar 

  22. Lassen NA, Andersen AR, Friberg L, Paulson OB (1988) The retention of 99 m-Tc-d, IHM-PAO in human brain after intracarotid bolus injection: A kinetic analysis. J. Cereb Blood Flow Metab 8: 13–22

    Google Scholar 

  23. Lassen NA, Sveinsdottir E, Kanno I, Stokely EM, Rommer P (1978) A fast rotating single photon emission tomograph for regional cerebral blood flow studies in man. J Comput Assist Tomogr 2: 660–661

    Article  Google Scholar 

  24. Lebrun-Grandié P, Baron J-C, Soussaline F, Loch’h C, Sastre J, Bousser M-G (1983) Coupling between regional cerebral blood flow and oxygen utilization in the normal human brain. Arch Neurol 40: 230–236

    Article  PubMed  Google Scholar 

  25. Madsen PL, Schmidt JF, Holm S, Jorgersen H, Wildschi¢dtz, Christensen NJ, Friberg L, Vorstrap S, Lassen NA (1992) Mental Stress and Cogretive performance do not increase overall level of cerebral 02. Update in humans. J Appl Physiol 73: 420–426

    Google Scholar 

  26. Mchaughlin T, Steinberg B, Christensen B, Law I, Parving A, Friberg L (1992) Potential language and attentional networks revealed through factor analysis of rCBF data. J Cereb Blood Flow Metab 12: 335–345

    Google Scholar 

  27. Mazziotta JC, Phelps ME (1984) Human sensory stimulation and deprivation: Positron emission tomographic results and strategies. Ann Neurol 15 [Suppl]: 50–60.

    Article  Google Scholar 

  28. Moskalenko YY (1975) Regional cerebral blood flow and its control at rest and during increased functional activity. In: Ingvar DH, Lassen Na (eds) Brain work. Munksgaard, Copenhagen, pp 343–351

    Google Scholar 

  29. Neirinckx RD, Burke JF, Harrison RC, Forster AM, Andersen AR, Lassen NA (1988) The retention mechanism of technetium-99 m-HM-PAO: Intracellular reaction with glutathione. J Cereb Blood Flow Metab 8: 4–12

    Google Scholar 

  30. Nishizawa Y, Olsen TS, Larsen B, Lassen NA (1982) Left-right cortical asymmetries of regional cerebral blood flow during listening to words. J Neurophysiol 48: 458–466

    PubMed  CAS  Google Scholar 

  31. Obrist WD, Thompson HK, Wang HS, Wilkinson WE (1975) Regional cerebral blood flow estimated by Xenon-133 inhalation. Stroke 6:245–256 Brain Mapping in Thinking and Language Function 39

    Google Scholar 

  32. Olesen J (1971) Contralateral focal increase of cerebral blood flow in man during arm work. Brain 94: 635–646

    Article  PubMed  CAS  Google Scholar 

  33. Olesen J, Paulson OB, Lassen NA (1971) Regional cerebral blood flow in man determined by initial slope of intra-arterially injected Xe-133. Stroke 2: 519–540

    Article  PubMed  CAS  Google Scholar 

  34. Penfield W (1966) Speech, perception and the uncommitted cortex. In: Eccels JC (ed) Brain and conscious experience. Springer, Berlin Heidelberg New York, pp 217–237

    Google Scholar 

  35. Prohovnik I, Knudsen E, Risberg J (1983) Accuracy of models and algorithms for determination of fast component flow by non-invasive Xenon-133 clearance. In: Magistretti PL (ed) Functional radionucleide imaging of the brain. Raven Press, New York, pp 97–115

    Google Scholar 

  36. Raichle ME, Grubb RL, Gado MH, Eichling JO, Ter-Pogossian MM (1976) Correlation between regional cerebral blood flow and oxidative metabolism Arch Neurol 33: 523–526

    CAS  Google Scholar 

  37. Risberg J, Ali Z, Wilson EM, Wills EL, Halsey JH (1975) Regional cerebral blood flow by Xenon-133 inhalation. Preliminary evaluation of an initial slope index in patients with unstable flow compartments. Stroke 6: 142–148

    Google Scholar 

  38. Roland PE (1982) Cortical regulation of selective attention in man. J Neurophysiol 48: 1059–1078

    PubMed  CAS  Google Scholar 

  39. Roland PE, Skinh¢j E, Lassen NA (1981) Focal activations of the human cerebral cortex during auditory discrimination. J Neurophysiol 45: 374–386

    Google Scholar 

  40. Roland PE, Friberg L (1985) Localization of cortical areas activated by thinking. J Neurophysiol 53: 1219–1243

    PubMed  CAS  Google Scholar 

  41. Roland PE, Eriksson L, Stone-Elander S, Widen L (1987) Increases of regional cerebral oxidative metabolism and regional cerebral blood flow provoked by visual imagery. J Neurosci 7: 2373

    PubMed  CAS  Google Scholar 

  42. Roland PE, Friberg L (1988) The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance. J Cereb Blood Flow Metab 8: 314–323

    Google Scholar 

  43. Roy CS, Sherrington CS (1890) On regulation of the blood supply of the brain. J Physiol (London) 11: 85–108

    CAS  Google Scholar 

  44. Rubin P, Holm S, Friberg L, Videbuk P, Andersen HS, BergBertsen B, Str¢ms¢ N, Lassen NA, Hemmingsen R (1991) Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophreria and schizo-phreriform disorder: A regional cerebral blood flow study. Arch Gen Psychiat 48: 987–995

    Google Scholar 

  45. Sokoloff L, Mangold R, Wechsler RL, Kennedy C, Kety SS (1955) The effect of mental arithmetic on cerebral circulation and metabolism. J Clin Invest 34: 1101–1108

    Article  PubMed  CAS  Google Scholar 

  46. Stokely EM, Sveinsdottir E, Lassen NA, Rommer P (1980) A single photon dynamic computer-assisted tomograph ( DCAT) for imaging brain function in multiple cross-sections. J Comput Assist Tomogr 4: 142–148

    Google Scholar 

  47. Sveinsdottir E, Larsen B, Rommer P, Lassen NA (1977) A multidetector scintillation camera with 254 channels. J Nucl Med 18: 168–174

    PubMed  CAS  Google Scholar 

  48. Wernicke C (1874) Der aphasische Symptomenkomplex. Cohn und Weigart, Breslau

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600, Glostrup, Copenhagen, Denmark

    L. Friberg

Authors
  1. L. Friberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Institute of Neurosurgery, Budapest, Hungary

    Emil Pásztor M.D.  & János Vajda M.D.  & 

  2. Neurochirurgische Universitätsklinik, Homburg/Saar, Federal Republic of Germany

    Friedrich Loew M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag

About this paper

Cite this paper

Friberg, L. (1993). Brain Mapping in Thinking and Language Function. In: Pásztor, E., Vajda, J., Loew, F. (eds) Language and Speech. Acta Neurochirurgica Supplementum, vol 56. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9239-9_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9239-9_7

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9241-2

  • Online ISBN: 978-3-7091-9239-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation