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Apolipoprotein E and the Response of the Brain to Injury

  • Conference paper
Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 73))

Summary

Apolipoprotein E (apoE) is an important part of the means by which lipids are transported in the nervous system. This transport system provides injured nerve cells, the cholesterol and phospholi-pids for the maintenance and repair of membranes, the growth of neuntes, dendritic remodelling and synaptogenesis, and the effect of injury to the nervous system is now known in part to be modulated by the various isoforms of apoE. After the demonstration of an association between the apoE ε4 and increased risk of subsequent development of both sporadic and late-onset form Alzheimer’s disease, recent studies have provided additional evidence for the possibility that apoE may play an isoform—specific role in determining both the initial response and the subsequent consequences to acute brain injury. Further studies are required to better understand not only the response(s) of the nervous system to injury, but also the relationship between acute injury to the brain and the subsequent development of neurodegenerative disorders.

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References

  1. Barger SW, Harmon RE (1997) Microglial activation by Alzheimer amyloid precursor protein and modulation of apolipo-protein E. Nature 388: 878–881

    Article  PubMed  CAS  Google Scholar 

  2. Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV (1996) Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Exp Neurol 138: 252–260

    Article  PubMed  CAS  Google Scholar 

  3. Gallo G, Wisniewski T, Choi-Miura NH, Ghiso J, Frangione B (1994) Potential role of apolipoprotein-E in fibrillogenesis. Am J Pathol 145: 526–530

    PubMed  CAS  Google Scholar 

  4. Gentleman SM, Greenberg BD, Savage MJ (1997) Aß42 is the predominant form of amyloid ß-protein in the brains of short-term survivors of head injury. Neuroreport 8: 1519–1572

    Article  PubMed  CAS  Google Scholar 

  5. Graham DI, Gentleman SM, Lynch A, Roberts GW (1995) Distribution of β-amyloid protein in the brain following severe head injury. Neuropath Appl Neurobiol 21: 27–34

    Article  CAS  Google Scholar 

  6. Greenberg SM, Briggs ME, Hyman BT, Kokoris GJ, Takis C, Kanter DS, Kase CS, Pessin MS (1996) Apolipoprotein E epi-solin 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke 27: 1333–1337

    Article  PubMed  CAS  Google Scholar 

  7. Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol Sci 12: 383–388

    Article  PubMed  CAS  Google Scholar 

  8. Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL (1995) Low density lipoprotein receptor-related protein mediates apolipoprotein E dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA 92: 9480–9484

    Article  PubMed  CAS  Google Scholar 

  9. Horsburgh K, Kelly S, McCulloch J, Higgins G, Roses AD, Nicoll JAR (1998) Apolipoprotein E deficient mice have increased neuronal damage following global ischaemia. Neurobiol Aging (abs)

    Google Scholar 

  10. Jordan BD, Relkin NR, Ravdin LD, Jacobs AR, Bennett A, Gandy S (1997) Apolipoprotein E epsilon-4 associated with chronic traumatic brain injury in boxing. JAMA 278: 136–140

    Article  PubMed  CAS  Google Scholar 

  11. Laskowitz DT, Sheng H, Bvart R, Joyner K, Roses AD, Warner D (1997) Apolipoprotein E deficient mice have increased susceptibility to focal cerebral ischemia. J Cereb Blood Flow Metab 17: 753–758

    Article  PubMed  CAS  Google Scholar 

  12. Lasowitz DT, Goel S, Bennett ER, Matthew WD (1997) Apolipoprotein E suppresses glial cell secretion of TNFα. J Neuro-immunol 76: 70–74

    Google Scholar 

  13. Ma J, Yee A, Brewer HB Jr, Das S, Potter H (1994) Amyloid-associated proteins alpha-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372: 92

    Article  PubMed  CAS  Google Scholar 

  14. Mayeux R, Ottman R, Rang MX, Noboa Banza L, Marer K, Gurland B, Stern Y (1993) Genetic susceptibility and head injury as risk factors for Alzheimer’s disease among community-dwelling elderly persons and their first-degree relatives. Ann Neurol 33: 494–501

    Article  PubMed  CAS  Google Scholar 

  15. Miyata M, Smith JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet 14: 55–61

    Article  PubMed  CAS  Google Scholar 

  16. Mortimer JA (1995) The epidemiology of Alzheimer’s disease: beyond risk factors. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM (eds) Research advances in Alzheimer’s disease and related disorders. John Wiley & Sons, Chichester, New York, pp 3–13

    Google Scholar 

  17. Mortimer JA, van Duijn CM, Chandra V (1991) Head trauma as a risk factor for Alzheimer’s disease: a collaborative re-analysis of case-controlled studies. Int J Epidemiol 20 [Suppl] 2:S28–S35

    Article  Google Scholar 

  18. Newman MF, Croughwell ND, Blumenthall JA, Lowry E, White WD, Spillane W, Davis RD, Glower DD, Smith LR, Mahanna EP (1995) Predictors of cardiac decline after cardiac operation. Ann Thorac Surg 59: 1326–1330

    Article  PubMed  CAS  Google Scholar 

  19. Nicoll JA, Burnett C, Love S, Graham DI, Ironside JW, Vinters HV (1996) High frequency of apolipoprotein E epsilon 2 in patients with cerebral hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 39: 682–683

    Article  PubMed  CAS  Google Scholar 

  20. Nicoll JAR, Roberts GW, Graham DI (1995) Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nature Med 1: 135–137

    Article  PubMed  CAS  Google Scholar 

  21. Poirier J (1994) Apolipoprotein E in animal models of CNS injury and in Alzheimer’s disease. Trends Neurosci 17: 525–530

    Article  PubMed  CAS  Google Scholar 

  22. Roberts GW, Gentleman SM, Lynch A, Murray L, Landon M, Graham DI (1994) ß-amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer’s disease. J Neurol Neurosurg Psychiatr 57: 419–425

    Article  PubMed  CAS  Google Scholar 

  23. Roses AD (1995) On the metabolism of apolipoprotein E and the Alzheimer’s diseases. Exp Neurol 132: 149–156

    Article  PubMed  CAS  Google Scholar 

  24. Roses AD (1996) Apolipoprotein E alleles as risk factors in AD. Ann Rev Med 47: 387–400

    Article  PubMed  CAS  Google Scholar 

  25. Roses AD, Saunders A, Corder EH, Risch NH, Haines, JL, Pericak-Vance M, Hans SH, Einstein G, Hulette C, Schmechel DE, Goedert M, Jakes R, Dong LM, Weisgraber KH, Holsti M, Huang D, Strittmatter WJ (1995) Apolipoprotein E and Alzheimer’s disease. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM (eds) Research advances in Alzheimer’s disease and related disorders. John Wiley & Sons, London, pp 85–96

    Google Scholar 

  26. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance M, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ et al (1994) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 43: 1467–1472

    Article  Google Scholar 

  27. Selkoe DJ (1994) Alzheimer’s disease: a central role for amyloid. J Neuropathol Exp Neurobiol 53: 438–447

    Article  CAS  Google Scholar 

  28. Slooter AJ, Tang MX, van Duijn CM, Stern Y, Ott A, Bell K, Breteler MM, Van Broeckhoven C, Tatemichi TK, Tycko B, Hofman A, Mayeux R (1997) Apolipoprotein E epsilon 4 and the risk of dementia with stroke. A population-based investigation. JAMA 277: 818–821

    CAS  Google Scholar 

  29. Sorbi S, Nacmias B, Piacentini S, Repice A, Latorraca S, Forleo P, Amaducci L (1995) ApoE as a prognostic factor for post-traumatic coma. Nature Med 1: 852

    Article  PubMed  CAS  Google Scholar 

  30. Strittmatter WJ, Saunders AM, Goedbert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD (1994) Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer’s disease. Proc Natl Acad Sci USA 91: 11183–11186

    Article  PubMed  CAS  Google Scholar 

  31. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer’s disease. Proc Natl Acad Sci USA 90: 1977–1981

    Article  PubMed  CAS  Google Scholar 

  32. Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD (1993) Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer’s disease. Proc Natl Acad Sci USA 90: 8098–8102

    Article  PubMed  CAS  Google Scholar 

  33. Teasdale GM, Nicoll, JAR, Murray G, Fiddes M (1997) Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 350: 1069–1071

    Article  PubMed  CAS  Google Scholar 

  34. Xu, P, Schmechel D, Rothrock-Christian T et al (1996) Human apolipoprotein E2, E3 and E4 isoform specific transgenic mice: human-like pattern of neuronal immunoreactivity in centralnervous system not observed in wildtype mice. Neurobiol Dis 3: 229–245

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neuropathology, University of Glasgow, Glasgow, Scotland, UK

    D. I. Graham, K. Horsburgh & J. A. R. Nicoll

  2. Department of Neurosurgery, University of Glasgow, Glasgow, Scotland, UK

    G. M. Teasdale

Authors
  1. D. I. Graham
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  2. K. Horsburgh
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  3. J. A. R. Nicoll
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  4. G. M. Teasdale
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Editors and Affiliations

  1. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Germany

    Alexander Baethmann , Nikolaus Plesnila , Florian Ringel  & Jörg Eriskat , ,  & 

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© 1999 Springer-Verlag Wien

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Graham, D.I., Horsburgh, K., Nicoll, J.A.R., Teasdale, G.M. (1999). Apolipoprotein E and the Response of the Brain to Injury. In: Baethmann, A., Plesnila, N., Ringel, F., Eriskat, J. (eds) Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia. Acta Neurochirurgica Supplements, vol 73. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6391-7_15

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  • DOI: https://doi.org/10.1007/978-3-7091-6391-7_15

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7312-1

  • Online ISBN: 978-3-7091-6391-7

  • eBook Packages: Springer Book Archive

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