Abstract
Cerebral vasospasm is the most frequent cause of morbidity and mortality in patients after SAH. The direct measurement of regional cerebral blood flow (rCBF) is a valuable adjunct for monitoring SAH patients. Single photon emission computed tomography (SPECT) with 99mTc-HMPAO is an adequate technique for the measurement of CBF [9, 10]. It measures the net effect of vasospasm on cerebral perfusion. 99mTc-HMPAO is a radioactive agent crossing the blood-brain barrier. It is trapped within the brain with flow-dependent distribution. Decreased cerebral uptake of 99mTc-HMPAO in cerebrovascular disease has been shown to correspond well with the results of other methods [3]. Despite a wide variety of treatment modalities no definitive treatment prevents vasospasm. Spinal cord stimulation (SCS) has been accepted to improve microcirculatory parameters in patients with critical limb ischemia [1]. Furthermore, it was proven that cervical spinal cord stimulation increases cerebral blood flow in normal conditions [4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Augustinsson LE, Carlsson CA, Holm J, Jivegard L (1985) Epidural electrical stimulation in severe limb ischemia. Ann Surg 202: 104–110
Brinker T, Seifert V, Dietz H (1992) Cerebral blood flow and intracranial pressure during experimental subarachnoid haemorrhage. Acta Neurochir (Wien) 115: 47–52
Büll U, Stirner H, Braun H, Kreiten K, Ferbert A (1987) SPECT with 99mTc-HMPAO and 99mTc-pertechnetate to assess regional cerebral blood flow (rCBF) and blood volume (rCBV). Preliminary results in cerbrovascular disease and interictal epilepsy. Nucl Med Comm 8: 519–524
Hosobuchi Y (1986) Electrical stimulation of the cervical spinal cord increases cerebral blood flow in humans. Appl Neurophysiol 48: 372–376
Juul R, Aakhus S, Björnstad K, Gisvold SE, Brubakk AO, Edvinsson L (1994) Calcitonin gene-related peptide (human α-CGRP) counteracts vasoconstriction in human subarachnoid haemorrhage. Neurosci Lett 170: 67–70
Linderoth B, Gheradini G, Ren B, Lundeberg T (1995) Preemptive spinal cord stimulation reduces ischemia in an animal model of vasospasm. Neurosurgery 37: 266–272
Liu-Chen LY, Mayberg MR, Moskowitz MA (1983) Immunohistochemical evidence for a substance P containing trigeminovascular pathway to pial arteries in cats. Brain Res 268: 162–166
Matsui T, Hosobuchi Y (1989) The effects of cervical spinal cord stimulation (cSCS) on experimental stroke. Pace-Pacing-Clin-Electrophysiol 12: 726–732
Naderi S, Özgüven MA, Bayhan H, Gökalp H, Erdogan A, Egemen N (1994) Evaluation of cerebral vasospasm in patients with subarachnoid hemorrhage using single photon emission computed tomography. Neurosurg Res 17: 261–265
Powsner RA, O’Tuama LA, Jabre A, Melhem ER (1998) SPECT imaging in cerebral vasospasm following subarachnoid hemorrhage. J Nucl Med 39: 765–769
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag
About this paper
Cite this paper
Ebel, H. et al. (2001). Effects of High Cervical Spinal Cord Stimulation (CSCS) on Regional Cerebral Blood Flow after Induced Subatachnoid Haemorrhage in Rats. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_48
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6232-3_48
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83650-7
Online ISBN: 978-3-7091-6232-3
eBook Packages: Springer Book Archive