Abstract
In vitro studies of subarachnoid hemorrhage (SAH) and vasospasm in animals involve the removal of the artery to be tested immediately after the animal has been killed [3]. The artery is then held in a fixation device and subjected to various test substances, which may include autologous blood. The artery is observed to determine whether contraction or relaxation occurs. Physiological, pharmacological, and morphological properties can be studied depending on the focus of the experiment. With the use of in vitro techniques, putative spasmogens have been studied, as well as potential vasospasm therapies [3].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Clower BR, Smith RR, Haining JL, Lockard J (1981) Constrictive endarteropathy following experimental subarachnoid hemorrhage. Stroke 12: 501–508
Espinosa F, Weir B, Overton T, Castor W, Grace M, Boisvert D (1984) A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys: part I — clinical and radiological findings. J Neurosurg 60: 1167–1175
Hongo K, Kobayashi S, Kassell NF (1990) In vitro perfusion system for the study of cerebral vasospasm. In: Sano K, Takakura K, Kassell NF, Sasaki T (eds) Cerebral vasospasm: Proceedings of the IVth International Conference on cerebral vasospasm. University of Tokyo Press, Tokyo, pp 203–206
Kaoutzanis M, Yokota M, Shibilia R, Peterson JW (1993) Neurologic evaluation in a canine model of single and double subarachnoid hemorrhage. J Neurosci Method 50: 301–307
Kistler JP, Crowell RM, Davis KR, Heros R, Ojemann RG, Zervas T, Fisher CM (1983) The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan: a prospective study. Neurology 33: 424–436
Mayberg MR, Okada T, Bark DH (1990) The significance of morphological changes in cerebral arteries after subarachnoid hemorrhage. J Neurosurg 72: 626–633
Megyesi JF, Vollrath B, Cook DA, Chen MH, Findlay JM (1999) Long-term effects of in vivo angioplasty in normal and vasospastic canine carotid arteries: pharmacological and morphological analyses. J Neurosurg 91: 100–108
Simeone FA, Vinall PE (1980) Evaluation of animal models of cerebral vasospasm. In: Wilkins RH (ed) Cerebral arterial spasm: Proceedings of the Second International Workshop. Williams and Wilkins, Baltimore, pp 284–286
Varsos VG, Liszczak TM, Han DH, Kistler JP, Vielma J, Black PMcL, Heros RC, Zervas NT (1983) Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a “two-hemorrhage” canine model. J Neurosurg 58: 11–17
Veelken JA, Laing RJC, Jakubowski J (1995) The Sheffield model of subarachnoid hemorrhage in rats. Stroke 26: 1279–1284
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer-Verlag
About this paper
Cite this paper
Megyesi, J.F., Findlay, J.M. (2001). In Vivo Animal Models of Cerebral Vasospasm: A Review. In: Seiler, R.W., Steiger, HJ. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 77. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6232-3_21
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6232-3_21
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83650-7
Online ISBN: 978-3-7091-6232-3
eBook Packages: Springer Book Archive