Zusammenfassung
Die Schmerzwahrnehmung, -modulation und -toleranz ist eine Gehirnleistung. Hemmsysteme modifizieren die Prozesse im unbewussten und bewussten Bereich. Die Antinozizeption erfolgt bereits als Teil des motorischen Programms. Sport steigert die Kapazität der Schmerzmodulation und -hemmung, wobei die Belastungsintensität sehr bedeutsam ist. Die physische Kondition ist eine Determinante der Schmerzhemmung. Sie geht vom PFC, MI, dem Dienzephalon, dem Hirnstamm, dem Locus coeruleus und dem PAG aus. Auch Testosteron ist mit ihr verknüpft.
Die Kapazität der Schmerzhemmung ergibt sich aus der „conditioned pain modulation“ (CPM), einem „Schmerz-hemmt-Schmerz-Mechanismus“ und der „exercise induced hypoalgesia“ (EIH). Beide Mechanismen interagieren. Die EIH ist bei Gesunden sicher durch ermüdendes Training auslösbar. Die Alterung mindert die Kapazität. Liegt eine CPM vor, reagieren Patienten wie Gesunde. Eine abnorme CPM diagnostiziert eine Dysfunktion auch der EIH. Grundsätzlich besteht aber Konsensus für die Belastungstherapie.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Aburn G, Gott M, Hoare K (2016) What is resilience? An Integrative Review of the empirical literature. J Adv Nurs 72(5):980–1000. https://doi.org/10.1111/jan.12888 (Epub 2016 Jan 7)
Alsouhibani A, Vaegter HB, Hoeger Bement M (2018) Systemic exercise-induced hypoalgesia following isometric exercise reduces conditioned pain modulation. Pain Med. https://doi.org/10.1093/pm/pny057 (Epub ahead of print)
Ambrose KR, Golightly YM (2015) Physical exercise as non-pharmacological treatment of chronic pain: why and when. Best Pract Res Clin Rheumatol 29(1):120–130. https://doi.org/10.1016/j.berh.2015.04.022 (Epub 23 May 2015)
Apkarian AV, Bushnell MC, Treede RD, Zubieta JK (2005) Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9(4):463–484 (Epub 21 Jan 2005)
Arendt-Nielsen L, Sluka KA, Nie HL (2008) Experimental muscle pain impairs descending inhibition. Pain 140:465–471
Bellgowan PS, Helmstetter FJ (1998) The role of mu and kappa opioid receptors within the periaqueductal gray in the expression of conditional hypoalgesia. Brain Res 791:83–89
Bement MKH, Sluka KA (2016) Exercise-induced analgesia: an evidence-based review. In: Sluka KA (Hrsg) Mechanisms and Management of Pain for the Physical Therapist, 2. Aufl., Ch. 10, S. 177–201. Wolters Kuwer & IASP Press, Seattle
Bingel U, Lorenz J, Glauche V, Knab R, Glascher J, Weiller C, Buchel C (2004) Somatotopic organization of human somatosensory cortices for pain : a single trail fMRI study. Neuroimage 23:224–232
Bingel U, Schoell E, Büchel C (2007) Imaging pain modulation in health and disease. Curr Opin Neurol 20(4):424–31
Bourne S, Machado AG, Nagel SJ (2014) Basic anatomy and physiology of pain pathways. Neurosurg Clin N Am 25(4):629–638. https://doi.org/10.1016/j.nec.2014.06.001 (Epub 3 Aug. 2014)
Brown JA (2001) Motor cortex stimulation. Neurosurg Focus. 11(3):E5
Butler RK, Finn DP (2009) Stress-induced analgesia. Prog Neurobiol 88:184–202
Cheng YY, Kao CL, Ma HI, Hung CH, Wang CT, Liu DH, Chen PY, Tsai KL (2015) SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through modulation of Toll-like receptor 4. J Biochem 158(4):299–308. https://doi.org/10.1093/jb/mvv041 (Epub 27 Apr. 2015)
Cho SS, Strafella AP (2009) rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex. PLoS ONE 4:e6725
Colloca L (2018) The placebo effect in pain therapies. Annu Rev Pharmacol Toxicol. https://doi.org/10.1146/annurev-pharmtox-010818-021542 (Epub ahead of print)
Cruccu G, Aziz TZ, Garcia-Larrea L, Hansson P, Jensen TS, Lefaucheur JP, Simpson BA, Taylor RS (2007) EFNS guidelines on neurostimulation therapy for neuropathic pain. Eur J Neurol 14(9):952–970
Cui RQ, Deecke L (1999) High resolution DC-EEG analysis of the Bereitschaftspotential and post movement onset potentials accompanying uni- or bilateral voluntary finger movements. Brain Topogr 11(3):233–249
Daenen L, Varkey E, Kellmann M, Nijs J (2015) Exercise, not to exercise, or how to exercise in patients with chronic pain? Applying science to practice. Clin J Pain 31(2):108–114. https://doi.org/10.1097/AJP.0000000000000099
Dafny N, Dong WQ, Prieto-Gomez C, Reyes-Vazquez C, Stanford J, Qiao JT (1996) Lateral hypothalamus: site involved in pain modulation. Neuroscience 70(2):449–460
De Martino E, Zandalasini M, Schabrun S, Petrini L, Graven-Nielsen T (2018a) Experimental muscle hyperalgesia modulates sensorimotor cortical excitability, which is partially altered by unaccustomed exercise. Pain 159(12):2493–2502. https://doi.org/10.1097/j.pain.0000000000001351
De Martino E, Seminowicz DA, Schabrun SM, Petrini L, Graven-Nielsen T (2018b) High frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex modulates sensorimotor cortex function in the transition to sustained muscle pain. Neuroimage 186:93–102. https://doi.org/10.1016/j.neuroimage.2018.10.076 (Epub ahead of print)
De Martino E, Petrini L, Schabrun S, Graven-Nielsen T (2018c) Cortical Somatosensory Excitability Is Modulated in Response to Several Days of Muscle Soreness. J Pain 19(11):1296–1307. https://doi.org/10.1016/j.jpain.2018.05.004 (Epub 25 Mai 2018)
Dowell D, Haegerich TM, Chou R (2016) CDC guideline for prescribing opioids for chronic pain – United States, 2016. J Am Med Assoc 315:1624–1645
Drew BT, Smith TO, Littlewood C, Sturrock B (2014) Do structural changes (eg, collagen/matrix) explain the response to therapeutic exercises in tendinopathy: a systematic review. Br J Sports Med 48(12):966–972. https://doi.org/10.1136/bjsports-2012-091285 (Epub 31 Oct 2012)
Fierro B, De TM, Giglia F, Giglia G, Palermo A, Brighina F (2010) Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) during capsaicin-induced pain: modulatory effects on motor cortex excitability. Exp Brain Res 203:31–38
Fingleton C, Smart K, Doody C, Dip T (2017) Exercise-induced hypoalgesia in people with knee osteoarthritis with normal and abnormal conditioned pain modulation. Clin J Pain 33:395–404
Flor H, Braun C, Elbert T, Birbaumer N (1997) Extensive reorganization of primary somatosensory cortex in chronic back pain patients. Neurosci Lett 224:5–8
Gajsar H, Titze C, Hasenbring MI, Vaegter HB (2017) Isometric back exercise has different effect on pressure pain thresholds in healthy men and women. Pain Med 18(5):917–923. https://doi.org/10.1093/pm/pnw176
Gajsar H, Nahrwold K, Titze C, Hasenbring MI, Vaegter HB (2018) Exercise does not produce hypoalgesia when performed immediately after a painful stimulus. Scand J Pain 18(2):311–320. https://doi.org/10.1515/sjpain-2018-0024
García-Larrea L, Peyron R, Mertens P, Gregoire MC, Lavenne F, Le Bars D, Convers P, Mauguière F, Sindou M, Laurent B (1999) Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study. Pain 83(2):259–273
Gold MS, Gebhart GF (2010) Nociceptor sensitization in pain pathogenesis. Nat Med 16:1248–1257
Hemington KS, Rogachov A, Cheng JC, Bosma RL Kim JA, Osborne NR, Inman RD, Davis KD (2018) Patients with chronic pain exhibit a complex relationship triad between pain, resilience, and within- and cross-network functional connectivity of the default mode network. Pain 159(8):1621–1630. https://doi.org/10.1097/j.pain.0000000000001252
Hoeger Bement MK, Dicapo J, Rasiarmos R, Hunter SK (2008) Dose response of isometric contractions on pain perception in healthy adults. Med Sci Sports Exerc 40(11):1880–1889. [PubMed:18845975]
Horn A, Ostwald D, Reisert M, Blankenburg F (2014) The structural-functional connectome and the default mode network of the human brain. Neuroimage 15(102 Pt 1):142–151. https://doi.org/10.1016/j.neuroimage.2013.09.069 (Epub 4 Oct. 2013)
Hosomi K, Saitoh Y, Kishima H, Oshino S, Hirata M, Tani N, Shimokawa T, Yoshimine T (2008) Electrical stimulation of primary motor cortex within the central sulcus for intractable neuropathic pain. Clin Neurophysiol 119(5):993–1001. (Epub 2008 Mar. 10)
Jennings EM, Okine BN, Roche M, Finn DP (2014) Stress-induced hyperalgesia. Prog Neurobiol 121:1–18. https://doi.org/10.1016/j.pneurobio.2014.06.003 (Epub 8 July 2014)
Kami K, Tajima F, Senba E (2017) Exercise-induced hypoalgesia: potential mechanisms in animal models of neuropathic pain. Anat Sci Int 92(1):79–90 (Epub 2 Aug. 2016)
Kennedy DL, Kemp HI, Ridout D, Yarnitsky D, Rice AS (2016) Reliability of conditioned pain modulation: a systematic review. Pain 157(11):2410–2419
Kosek E, Ordeberg G (2000) Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain 88:69–78
Lannersten L, Kosek E (2010) Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia. Pain 151:77–86
Le Bars D (2002) The whole body receptive field of dorsal horn multireceptive neurones. Brain Res Brain Res Rev 40(1–3):29–44
Le Bars D, Dickenson AH, Besson JM (1979a) Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 6(3):283–304
Le Bars D, Dickenson AH, Besson JM (1979b) Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications. Pain 6(3):305–327
Lefaucheur JP, Drouot X, Cunin P, Bruckert R, Lepetit H, Créange A, Wolkenstein P, Maison P, Keravel Y, Nguyen JP (2009) Motor cortex stimulation for the treatment of refractory peripheral neuropathic pain. Brain 132(6):1463–1471. https://doi.org/10.1093/brain/awp035 (Epub 31 Mar. 2009)
Lemley KJ, Hunter SK, Bement MK (2015) Conditioned pain modulation predicts exercise-induced hypoalgesia in healthy adults. Med Sci Sports Exerc 47(1):176–184 (PubMed: 24870571)
Levine JD, Gordon NC, Fields HL (1978) The mechanism of placebo analgesia. Lancet 2(8091):654–657
Levy R, Deer TR, Henderson J (2010) Intracranial neurostimulation for pain control: a review. Pain Physician 13(2):157–165
Li Y, Wang Y, Xuan C, Li Y, Piao L, Li J, Zhao H (2017) Role of the lateral habenula in pain-associated depression. Front Behav Neurosci 11:31. https://doi.org/10.3389/fnbeh.2017.00031 (eCollection 2017)
Lima LV, Abner TSS, Sluka KA (2017) Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena. J Physiol 595(13):4141–4150. https://doi.org/10.1113/JP273355 (Epub 2017 May 26)
Lucas JM, Ji Y, Masri R (2011) Motor cortex stimulation reduces hyperalgesia in an animal model of central pain. Pain 152(6):1398–1407. (Epub 2011 Mar 10)
Mackenzie J (1909) Counter-Irritation. Proc R Soc Med 2(Ther Pharmacol Sect):75–80
Maihöfner C, Nickel FT, Seifert F (2010) Neuropathic pain and neuroplasticity in functional imaging studies. Schmerz 24(2):137–145
Marinelli S, Vaughan CW, Schnell SA, Wessendorf MW, Christie MJ (2002) Rostral ventromedial medulla neurons that project to the spinal cord express multiple opioid receptor phenotypes. J Neurosci 22(24):10847–10855
Martel MO, Petersen K, Cornelius M, Arendt-Nielsen L, Edwards R (2018) Endogenous pain modulation profiles among individuals with chronic pain: Relation to opioid use. J Pain. pii: S1526-5900(18)30759-4. https://doi.org/10.1016/j.jpain.2018.10.004 (Epub ahead of print)
Melzack R, Wall PD (1965) Pain mechanisms: a new theory. Science 150:971–979
Millan MJ (2002) Descending control of pain. Prog Neurobiol 66(6):355–474
Moisset X, de Andrade DC, Bouhassira D (2016) From pulses to pain relief: an update on the mechanisms of rTMS-induced analgesic effects. Eur J Pain 20(5):689–700. https://doi.org/10.1002/ejp.811 (Epub 16 Oct 2015)
Monconduit L, Desbois C, Villanueva L (2002) The integrative role of the rat medullary subnucleus reticularis dorsalis in nociception. Eur J Neurosci 16(5):937–944
Naugle KM, Fillingim RB, Riley JL (2012) A meta-analytic review of the hypoalgesic effects of exercise. J Pain 13(12):1139–1150. https://doi.org/10.1016/j.jpain.2012.09.006 (Epub 8 Nov. 2012)
Naugle KM, Naugle KE, Riley JL 3rd (2016) Reduced Modulation of Pain in Older Adults After Isometric and Aerobic Exercise. J Pain 17(6):719–728. https://doi.org/10.1016/j.jpain.2016.02.013 (Epub 2016 Mar 15)
Naugle KM, Ohlman T, Naugle KE, Riley ZA, Keith NR (2017) Physical activity behavior predicts endogenous pain modulation in older adults. Pain 158(3):383–390. https://doi.org/10.1097/j.pain.0000000000000769
Neugebauer V (2015) Amygdala pain mechanisms. Handb Exp Pharmacol 227:261–284. https://doi.org/10.1007/978-3-662-46450-2_13
Nguyen JP, Lefaucheur JP, Decq P, Uchiyama T, Carpentier A, Fontaine D, Brugières P, Pollin B, Fève A, Rostaing S, Cesaro P, Keravel Y (1999) Chronic motor cortex stimulation in the treatment of central and neuropathic pain. Correlations between clinical, electrophysiological and anatomical data. Pain 82(3):245–251
Nir RR, Yarnitsky D (2015) Conditioned pain modulation. Curr Opin Support Palliat Care 9(2):131–137. https://doi.org/10.1097/SPC.0000000000000126
O’Connell NE, Marston L, Spencer S, DeSouza LH, Wand BM (2018) Non-invasive brain stimulation techniques for chronic pain. Cochrane Database Syst Rev 16(3):CD008208. https://doi.org/10.1002/14651858.cd008208.pub4
Ohlman T, Miller L, Naugle KE, Naugle KM (2018) Physical activity levels predict exercise-induced hypoalgesia in older adults. Med Sci Sports Exerc 50(10):2101–2109. https://doi.org/10.1249/MSS.0000000000001661
Ossipov MH, Dussor GO, Porreca F (2010) Central modulation of pain. J Clin Invest 120(11):3779–3787. https://doi.org/10.1172/JCI43766 (Epub 1 Nov. 2010)
Pagano RL, Assis DV, Clara JA, Alves AS, Dale CS, Teixeira MJ, Fonoff ET, Britto LR (2011) Transdural motor cortex stimulation reverses neuropathic pain in rats: a profile of neuronal activation. Eur J Pain 15(3):268.e1–14
Piché M, Arsenault M, Rainville P (2009) Cerebral and cerebrospinal processes underlying counterirritation analgesia. J Neurosci 29(45):14236–14246
Quante M, Hille s, Schofer MD, Lorenz J, Hauck M (2008) Noxious counterirritation in patients with advanced osteoarthritis of the knee reduces MCC but not SII pain generators: A combined use of MEG and EEG. J Pain Res 1:1–8
Rainov NG, Fels C, Heidecke V, Burkert W (1997) Epidural electrical stimulation of the motor cortex in patients with facial neuralgia. Clin Neurol Neurosurg 99(3):205–209
Rohde J (2009) Untersuchung und Therapie am Periost. Zur segmentalen Innervation des Periostes. Manuelle Medizin 47:334–342. https://doi.org/10.1007/s00337-009-0702-1
Rohde J (2010) Schmerztherapie über das Periost. Manuelle Medizin 48:447–453. https://doi.org/10.1007/s00337-010-0808-5
Schaible HG, Richter F (2004) Pathophysiologiy of pain. Langenbecks Arch Surg 389:237–243
Schabrun SM, Christensen SW, Mrachacz-Kersting N, Graven-Nielsen T (2016) Motor cortex reorganization and impaired function in the transition to sustained muscle pain. Cereb Cortex 26:1878–1890
Schaible HG, Del Rosso A, Matucci-Cerinic M (2005) Neurogenic aspects of inflammation. Rheum Dis Clin North Am 31:77–101
Schaible HD, Ebersberger A, Natura G (2011) Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines. Arthritis Res Therapy 13:210. http://arthritis-research.com/content/13/210
Seminowicz DA, de Martino E, Schabrun SM, Graven-Nielsen T (2018) Left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation reduces the development of long-term muscle pain. Pain 159(12):2486–2492. https://doi.org/10.1097/j.pain.0000000000001350
Shen J, Fox LE, Cheng J (2013) Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats. Pain Med 14(4):516–525. https://doi.org/10.1111/pme.12057 (Epub 25 Febr. 2013)
Sibon I, Strafella AP, Gravel P, Ko JH, Booij L, Soucy JP, Leyton M, Diksic M, Benkelfat C (2007) Acute prefrontal cortex TMS in healthy volunteers: effects on brain 11C-alphaMtrp trapping. Neuroimage 34:1658–1664
Smith A, Ritchie C, Pedler A, McCamley K, Roberts K, Sterling M (2017) Exercise induced hypoalgesia is elicited by isometric, but not aerobic exercise in individuals with chronic whiplash associated disorders. Scand J Pain 15:14–21. https://doi.org/10.1016/j.sjpain.2016.11.007 (Epub 6 Dec. 2016)
Sounvoravong S, Nakashima MN, Wada M, Nakashima K (2004) Decrease in serotonin concentration in raphe magnus nucleus and attenuation of morphine analgesia in two mice models of neuropathic pain. Eur J Pharmacol 484(2–3):217–223
Stolzman S, Lemley K, Hoffmeister K, Coate M, Drendel A, Hoeger Bement M (2014) Conditioned pain modulation and exercise-induced hypoalgesia in adolescents. Pediatric Physical Therapy: The Official Publication of the Section on Pediatrics of the American Physical Therapy Association 26(1):154–155
Stolzman S, Danduran M, Hunter SK, Bement MH (2015) Pain response after maximal aerobic exercise in adolescents across weight status. Med Sci Sports Exerc 47(11):2431–2440. [PubMed:25856681]
Stolzman S, Hoeger Bement M (2016) Lean mass predicts conditioned pain modulation in adolescents across weight status. Eur J Pain 20(6):967–976. https://doi.org/10.1002/ejp.821 (Epub 13 Jan. 2016)
Stolzman S, Bement MH (2016) Does exercise decrease pain via conditioned pain modulation in adolescents? Pediatr Phys Ther 28(4):470–473. https://doi.org/10.1097/pep.0000000000000312
Tamano R, Ishida M, Asaki T, Hasegawa M, Shinohara S (2016) Effect of spinal monoaminergic neuronal system dysfunction on pain threshold in rats, and the analgesic effect of serotonin and norepinephrine reuptake inhibitors. Neurosci Lett 26(615):78–82. https://doi.org/10.1016/j.neulet.2016.01.025 (Epub 19 Jan 2016)
Taylor JJ, Borckardt JJ, George MS (2012) Endogenous opioids mediate left dorsolateral prefrontal cortex rTMS-induced analgesia. Pain 153:1219–1225
Taylor JJ, Borckardt JJ, Canterberry M, Li X, Hanlon CA, Brown TR, George MS (2013) Naloxone-reversible modulation of pain circuitry by left prefrontal rTMS. Neuropsychopharmacology 38:1189–1197
Toubia T, Khalife T ( 2018 ) The endogenous opioid system: role and dysfunction caused by opioid therapy. Clin Obstet Gynecol. https://doi.org/10.1097/grf.0000000000000409 (Epub ahead of print)
Travers M, Moss P, Gibson W, Hince D, Yorke S, Chung C, Langford R, Tan EEW, Ng J, Palsson TS (2018) Exercise-induced hypoalgesia in women with varying levels of menstrual pain. Scand J Pain 18(2):303–310. https://doi.org/10.1515/sjpain-2018-0020
Treede RD, Kenshalo DR, Gracely RH, Jones A (1999) The cortical representation of pain. Pain 79:105–111
Tsao JC, Seidman LC, Evans S, Lung KC, Zeltzer LK, Naliboff BD (2013) Conditioned pain modulation in children and adolescents: effects of sex and age. J Pain 14(6):558–567 (PubMed:23541066)
Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S (1991a) Treatment of thalamic pain by chronic motor cortex stimulation. Pacing Clin Electrophysiol 14(1):131–134
Tsubokawa T, Katayama Y, Yamamoto T, Hirayama T, Koyama S (1991b) Chronic motor cortex stimulation for the treatment of central pain. Acta Neurochir Suppl (Wien) 52:137–139
Vaegter HB, Handberg G, Graven-Nielsen T (2014) Similarities between exercise-induced hypoalgesia and conditioned pain modulation in humans. Pain 155(1):158–167 https://doi.org/10.1016/j.pain.2013.09.023(Epub 2013 Sep 26)
Vaegter HB, Handberg G, Jorgensen MN, Kinly A, Graven-Nielsen T (2015) Aerobic exercise and cold pressor test induce hypoalgesia in active and inactive men and women. Pain Med 16(5):923–933 (PubMed: 25530341)
Vaegter HB, Handberg G, Graven-Nielsen T (2016) Hypoalgesia after exercise and the cold pressor test is reduced in chronic musculoskeletal pain patients with high pain sensitivity. Clin J Pain 32(1):58–69. https://doi.org/10.1097/AJP.0000000000000223
Vaegter HB, Handberg G, Emmeluth C, Graven-Nielsen T (2017) Preoperative hypoalgesia after cold pressor test and aerobic exercise is associated with pain relief 6 months after total knee replacement. Clin J Pain 33(6):475–484. https://doi.org/10.1097/AJP.0000000000000428
Vaegter HB, Dørge DB, Schmidt KS, Jensen AH, Graven-Nielsen T (2018) Test-retest reliabilty of exercise-induced hypoalgesia after aerobic exercise. Pain Med 19(11):2212–2222. https://doi.org/10.1093/pm/pny009
Velasco F, Carrillo-Ruiz JD, Castro G, Argüelles C, Velasco AL, Kassian A, Guevara U (2009) Motor cortex electrical stimulation applied to patients with complex regional pain syndrome. Pain 147(1-3):91–8. https://doi.org/10.1016/j.pain.2009.08.024 (Epub 29 Sept. 2009)
Vogt BA (2005) Pain and emotion. Interactions in subregions of the cingulated cortex. Nat Rev Neurosci 6:533–544
van Wijk G, Veldhuijzen DS (2010) Perspective on diffuse noxious inhibitory controls as a model of endogenous pain modulation in clinical pain syndromes. J Pain 11(5):408–419 (PubMed:20075013)
Vogler P (1953) Periostbehandlung. Thieme, Stuttgart
Vogler P, Krauß H (1980) Periostbehandlung – Kolonbehandung. Zwei reflextherapeutische Methoden. Thieme, Stuttgart
Wager TD, Atlas LY (2015) The neuroscience of placebo effects: connecting context, learning and health. Nat Rev Neurosci 16(7):403–418. https://doi.org/10.1038/nrn3976
Whitson HE, Duan-Porter W, Schmader KE, Morey MC, Cohen HJ, Colón-Emeric CS (2016) Physical resilience in older adults: systematic review and development of an emerging construct. J Gerontol A Biol Sci Med Sci 71(4):489–495. https://doi.org/10.1093/gerona/glv202 (Epub 29 Dec. 2015)
Wiedenmayer CP, Barr GA (2000) Mu opioid receptors in the ventrolateral periaqueductal gray mediate stress-induced analgesia but not immobility in rat pups. Behav Neurosci 114:125–136
Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O (2010) Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain 14:339
Yunhai Q, Yasuki N, Honda M, Nakata H, Tamura Y, Tanaka S, Sadato N, Wang X, Inui K, Kakigi R (2006) Brain processing of the signals ascending through unmyelinated C fibers in humans: An event-related functional magnetic resonance imaging study. Cerebral Cortex 16:1289–1295 https://doi.org/10.1093/cercor/bhj071
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature
About this chapter
Cite this chapter
Laube, W. (2020). Sensomotorik und antinozizeptive Systeme und deren Kapazität. In: Sensomotorik und Schmerz. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60512-7_8
Download citation
DOI: https://doi.org/10.1007/978-3-662-60512-7_8
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-60511-0
Online ISBN: 978-3-662-60512-7
eBook Packages: Medicine (German Language)