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Nanotechnology-Based Stem Cell Tissue Engineering with a Focus on Regeneration of Cardiovascular Systems

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Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy

Abstract

This chapter outlines the main stem cell lines and nanomaterials utilized in tissue engineering for regenerative medicine, with a distinct focus on the cardiovascular system, which is our research area of interest.

Funding/Disclosures: Partial funding was provided by NSF-CBET-1659244, and George M. and Boyce W. Billingsley Endowment Fund for Dr. Rao, as well as NSF-CMMI-1235100, NSF-OIA-1457888, and Arkansas Biosciences Institute for Dr. Kim.

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Abbreviations

AFPC:

Amniotic fluid progenitor cells

AgNP:

Silver nanoparticle

AuNP:

Gold particle

bFGF:

Basic fibroblast growth factor

BM-MSC:

Bone marrow-derived mesenchymal stem cells

CAD:

Computer-aided software

CAFC:

Cobblestone area formation assay

CFU:

Colony formation unit assay

CM:

Cardiomyocyte

CNC:

Cellulose nanocrystals

CNT:

Carbon nanotube

CRU:

Competitive repopulating unit assay

CVD:

Chemical vapor deposition

DNA:

Deoxyribonucleic acid

EB:

Embryoid body

EC:

Endothelial cell

ECM:

Extracellular matrix

ESC:

Embryonic stem cells

FACS:

Fluorescence-activated cell sorting

FDM:

Fused deposition modeling

FGF:

Fibroblast growth factor

GelMA:

Carbon nanotube-gelatin methacrylate

GM:

Gelatin microspheres

GO:

Graphene oxide

HA:

Hyaluronic acid

HAp/CS-Gel:

Hydroxyapatite/chitosan–gelatin

hASCs:

Human adipose mesenchymal stem cells

hESC:

Human embryonic stem cells

HIPE:

High internal phase emulsion

hNSCs:

Human neural stem cells

HSCs:

Hematopoietic stem cells

IGF:

Insulin growth factor

iPSC:

Induced pluripotent stem cells

KOSR:

Knockout serum replacement

LIF:

Leukemia inhibitory factor

LSPR:

Localized surface plasma resonance

LT-IC:

Long-term culture initiation assay

MI:

Myocardial infarction

miRNA:

Micro-RNA

MRI:

Magnetic resonance imaging

MSC:

Mesenchymal stromal cells

MWNT:

Multi-walled carbon nanotube

NFC-X:

Nanofibrillated cellulose

NF-kB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NPs:

Nanoparticles

PBAE:

Biodegradable poly (β-amino-ester)

PCL:

Polycaprolactone

PEG-DA:

Polyethylene (glycol) diacrylate

PEI:

Polyethyleneimine

PGLA:

Polylactic-co-glycolic acid

PLA:

Polylactic acid

PS:

Protamine sulfate

QD:

Quantum dot

RBMSCs:

Rat bone marrow stromal cells

RGO:

Reduced graphene oxide

RNA:

Ribonucleic acid

SCNT:

Somatic cell nuclear transfer

SG:

Single-layer graphene

SL:

Stereolithography

SPIO:

Superparamagnetic iron oxide nanoparticle

SWNT:

Single-walled carbon nanotube

TCP:

Tricalcium phosphate

TGF:

Transforming growth factor

TiO2NP:

Titanium dioxide-based nanoparticle

UDSCs:

Urine-derived stem cells

VEGF:

Vascular endothelial growth factor

ZnONP:

Zinc-oxide-based nanoparticle

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR, USA

    Srikanth Sivaraman, Raj Rao & Hanna Jensen

  2. Department of Biological and Agricultural Engineering, University of Arkansas, Fayetteville, AR, USA

    Arvind Sinha & Jin-Woo Kim

  3. Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR, USA

    Arvind Sinha & Jin-Woo Kim

  4. Department of Biosystems Engineering, Kangwon National University, Chuncheon, Republic of Korea

    Ki-Taek Lim

Authors
  1. Srikanth Sivaraman
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  2. Arvind Sinha
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  3. Ki-Taek Lim
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  4. Jin-Woo Kim
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  5. Raj Rao
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  6. Hanna Jensen
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Corresponding authors

Correspondence to Jin-Woo Kim , Raj Rao or Hanna Jensen .

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  1. Integrated Mesoscale Architectures for Sustainable Catalysis (IMASC), Rowland Institute of Science, Harvard University, Cambridge, MA, USA

    Challa S.S.R. Kumar

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Sivaraman, S., Sinha, A., Lim, KT., Kim, JW., Rao, R., Jensen, H. (2019). Nanotechnology-Based Stem Cell Tissue Engineering with a Focus on Regeneration of Cardiovascular Systems. In: Kumar, C. (eds) Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59596-1_1

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