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Skin Vaccination Methods: Gene Gun, Jet Injector, Tattoo Vaccine, and Microneedle

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Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

Abstract

The natural biological function of the skin is to protect the body against harmful infections by hindering the intrusion of foreign pathogens. In terms of protection, the skin serves a dual functionality: the physical barrier provided by the stratum corneum and the immunological barrier stimulated by the antigen-presenting cells (APCs) in the dermis and epidermis. In recent years, several findings have established that stimulating the APCs underneath the stratum corneum can provide several advantages in terms of vaccine administration over conventional methods. Hence, such “intradermal immunization” methods have been investigated worldwide. As a result, some of the intradermal vaccine delivery methods that were developed include the Mantoux technique, ballistic vaccination, epidermal powder immunization (EPI), jet injector, tattoo immunization, and microneedles. This chapter attempts to briefly delineate these methods and describe the state of research regarding these technologies in the present day.

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  1. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, Republic of Korea

    Yeu-Chun Kim

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    Howard I. Maibach

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Kim, YC. (2017). Skin Vaccination Methods: Gene Gun, Jet Injector, Tattoo Vaccine, and Microneedle. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53273-7_30

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