Zusammenfassung
Nach einer kurzen Einführung in das therapeutische Drug Monitoring (TDM) wird die praktische Durchführung von TDM beschrieben. An Einzelfällen wird beispielhaft dargestellt, wie TDM für die Steuerung der antidepressiven Therapie sinnvoll genutzt werden kann. Es soll verdeutlicht werden, dass TDM ein Instrument der individualisierten Pharmakotherapie ist, ein Werkzeug für rationale Pharmakotherapie.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Asberg M, Cronholm B, Sjöqvist F, Tuck D (1970) Correlation of subjective side effects with plasma concentrations of nortriptyline. Br Med J 4(5726):18–21
Asberg M, Crönholm B, Sjöqvist F, Tuck D (1971) Relationship between plasma level and therapeutic effect of nortriptyline. Br Med J 3(5770):331–334
Adli M, Baethge C, Heinz A et al (2005) Is dose escalation of antidepressants a rational strategy after a medium-dose treatment has failed? A systematic review. Eur Arch Psychiatry Clin Neurosci 255(6):387–400
Baumann P, Hiemke C, Ulrich S et al (2004) The AGNP-TDM Expert Group Consensus Guidelines: Therapeutic drug monitoring in psychiatry. Pharmacopsychiatry 37:243–265
Bengtsson F (2004) Therapeutic drug monitoring of psychotropic drugs. TDM “nouveau”. Ther Drug Monit 26(2):145–151
Bundesärztekammer (2014) Richtlinie der Bundesärztekammer zur Qualitätssicherung laboratoriumsmedizinischer Untersuchungen Deutsches Ärzteblatt 111: A1583-A1618 http://www.bundesaerztekammer.de/fileadmin/user_upload/downloads/Rili-BAEK-Laboratoriumsmedizin.pdf. Zugegriffen: 14. Apr 2016
Crettol S, de Leon J, Hiemke C, Eap CB (2014) Pharmacogenomics in psychiatry: from therapeutic drug monitoring to genomic medicine. Clin Pharmacol Ther 95(3):254–257
Eap CB, Jaquenoud Sirot E, Baumann P (2004) Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies. Ther Drug Monit 26:152–155
Haen E, Greiner C, Bader W, Wittmann M (2008) Wirkstoffkonzentrationsbestimmungen zur Therapieleitung. Ergänzung therapeutischer Referenzbereiche durch dosisbezogene Referenzbereiche. Nervenarzt 79(5):558–566
Hiemke C, Eckermann G (2014) Kombinationstherapie/Polypharmazie: Interaktionen von Psychopharmaka. Psychopharmakotherapie 21:269–279
Hiemke C, Dragicevic A, Kuss H-J et al (2005) TDM zur Optimierung der antidepressiven Pharmakotherapie. Med Welt 56:338–343
Hiemke C, Baumann P, Bergemann N, Conca A, Dietmaier O, Egberts K, Fric M, Gerlach M, Greiner C, Gründer G, Haen E, Havemann-Reinecke U, Jaquenoud Sirot E, Kirchherr H, Laux G, Lutz UC, Messer T, Müller MJ, Pfuhlmann B, Rambeck B, Riederer P, Schoppek B, Stingl J, Uhr M, Ulrich S, Waschgler R, Zernig G (2011) AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011. Pharmacopsychiatry 44(6):195–235
Isacsson G, Bergman U, Wasserman D et al (1996) The use of antidepressants and therapeutic drug monitoring by general practitioners and psychiatrists: findings from a questionnaire survey in two Swedish areas. Ann Clin Psychiatry 8(3):153–160
Jaquenoud Sirot E, van der Velden JW, Rentsch K et al (2006) Therapeutic drug monitoring and pharmacogenetic tests as tools in pharmacovigilance. Drug Saf 29:735–768
Johne A, Schmider J, Brockmöller J et al (2002) Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John’s wort (Hypericum perforatum). J Clin Psychopharmacol 22(1):46–54
Kootstra-Ros JE, Van Weelden MJ, Hinrichs JW et al (2006) Therapeutic drug monitoring of antidepressants and cytochrome p450 genotyping in general practice. J Clin Pharmacol 46(11):1320–1327
Lingam R, Scott J (2002) Treatment non-adherence in affective disorders. Acta Psychiatr Scand 105(3):164–172
Lundmark J, Bengtsson F, Nordin C et al (2000) Therapeutic drug monitoring of selective serotonin reuptake inhibitors influences clinical dosing strategies and reduces drug costs in depressed elderly patients. Acta Psychiatr Scand 101:354–359
Mann K, Hiemke C, Schmidt LG, Bates DW (2006) Appropriateness of therapeutic drug monitoring for antidepressants in routine psychiatric inpatient care. Ther Drug Monit 28:83–88
Müller MJ, Dragicevic A, Fric M et al (2003). Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions? Pharmacopsychiatry 36(3):98–104
Ostad Haji E, Hiemke C, Pfuhlmann B (2012) Therapeutic drug monitoring for antidepressant drug treatment. Curr Pharm Des 18(36):5818–5827
Ostad Haji E, Mann K, Dragicevic A et al (2013a) Potential cost-effectiveness of therapeutic drug monitoring for depressed patients treated with citalopram. Ther Drug Monit 35(3):396–401
Ostad Haji E, Tadic A, Wagner S et al (2013b) Early improvement and serum concentrations of citalopram to predict antidepressant drug response of patients with major depression. Pharmacopsychiatry 46(7):261–266
Preskorn SH, Simpson S (1982) Tricyclic-antidepressant-induced delirium and plasma drug concentration. Am J Psychiatry 139(6):822–823
Preskorn SH, Burke MJ, Fast GA (1993) Therapeutic drug monitoring. Principles and practice. Psychiatr Clin North Am 16(3):611–645
Simmons SA, Perry PJ, Rickert ED, Browne JL (1985) Cost-benefit analysis of prospective pharmacokinetic dosing of nortriptyline in depressed inpatients. J Affect Disord 8:47–53
Stamm TJ, Becker D, Sondergeld LM et al (2014) Prediction of antidepressant response to venlafaxine by a combination of early response assessment and therapeutic drug monitoring. Pharmacopsychiatry 47(4–5):174–179
Vuille F, Amey M, Baumann P (1991) Use of plasma level monitoring of antidepressants in clinical practice – towards an analysis of clinical utility. Pharmacopsychiatry 24:190–195
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
1 Elektronische Zusatzmaterial
1 Elektronische Zusatzmaterial
1 Elektronische Zusatzmaterial
1 Elektronische Zusatzmaterial
Rights and permissions
Copyright information
© 2017 Springer-Verlag GmbH Deutschland
About this chapter
Cite this chapter
Hiemke, C. (2017). Therapeutisches Drug Monitoring. In: Konrad, C. (eds) Therapie der Depression. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50347-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-662-50347-8_10
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-50346-1
Online ISBN: 978-3-662-50347-8
eBook Packages: Medicine (German Language)