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Surfactants as Penetration Enhancers for Dermal and Transdermal Drug Delivery

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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

Owing to the specific molecular structure of surfactants, these compounds can penetrate into the stratum corneum (SC) and thereby increase the transdermal absorption of drugs. As a result, surfactants are some of the most widely used enhancers in transdermal drug delivery formulations/systems. Starting with an introduction into the chemical structure and physicochemical characteristics of surfactants, this chapter is focused on the application of various surfactants for increasing the skin absorption of drugs and the mechanisms involved in this process. In particular, application of various ionic and nonionic surfactants and synergism with physical and chemical permeation enhancement methods such as electrophoresis have been discussed, and key publications in this subject area have been introduced.

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Authors and Affiliations

  1. Chemistry and Drug Delivery Group, Medway School of Pharmacy, Universities of Kent and Greenwich, Kent, UK

    Taravat Ghafourian

  2. Drug Applied Research Center and Faculty of Pharmacy, Tabriz Medical Sciences University, Tabriz, Iran

    Taravat Ghafourian

  3. School of Life Sciences, University of Sussex, JMS Building, Brighton, BN1 9QG, UK

    Ali Nokhodchi

  4. School of Pharmacy, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK

    Waseem Kaialy

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  1. Taravat Ghafourian
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  2. Ali Nokhodchi
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  3. Waseem Kaialy
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Correspondence to Ali Nokhodchi .

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  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. Dermatology Clinic, University of California San Francisco Dermatology Clinic, San Francisco, USA

    Howard I. Maibach

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Ghafourian, T., Nokhodchi, A., Kaialy, W. (2015). Surfactants as Penetration Enhancers for Dermal and Transdermal Drug Delivery. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_13

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