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Hemodialysis in Children

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Pediatric Nephrology

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Abstract

Chronic dialysis, including both hemodialysis and peritoneal dialysis, is technically feasible in children of all ages, including neonates [1]. In countries with active pediatric transplant programs, however, dialysis would not be the first choice of renal replacement therapy, as most pediatric nephrologists would aim for preemptive transplants in their patients. Despite that aim, across Europe half of patients start renal replacement therapy on peritoneal dialysis and one third on hemodialysis, and only the remainder are transplanted preemptively [2]. Some children will inevitably require a period on dialysis, such as the infant in whom dialysis may be necessary until adequate size for transplant is reached, the child needing urgent treatment because of presentation in end-stage kidney disease, and children needing native nephrectomies pre-transplant. Furthermore, only a minority of children are able to escape a period of dialysis either while waiting for their first transplant or because of subsequent graft failure. This means that overall, at any time, around 20 % of the pediatric end-stage kidney disease population is dialyzed [3, 4].

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References

  1. Rees L. Paediatrics: infant dialysis-what makes it special? Nat Rev Nephrol. 2013;9(1):15–7.

    Article  PubMed  Google Scholar 

  2. Watson AR, Hayes WN, Vondrak K, Ariceta G, Schmitt CP, Ekim M, Fischbach M, Edefonti A, Shroff R, Holta T, Zurowska A, Klaus G, Bakkaloglu S, Stefanidis CJ, Van de Walle J, European Paediatric Dialysis Working Group. Factors influencing choice of renal replacement therapy in European paediatric nephrology units. Pediatr Nephrol. 2013;28(12):2361–8.

    Article  PubMed  Google Scholar 

  3. www.renalreg.com

  4. www.usrds.org

  5. Fadrowski JJ, Frankenfield D, Amaral S, Brady T, Gorman GH, Warady B, Furth SL, Fivush B, Neu AM. Children on long-term dialysis in the United States: findings from the 2005 ESRD clinical performance measures project. Am J Kidney Dis. 2007;50:958–66.

    Article  CAS  PubMed  Google Scholar 

  6. Fontana I, Santori G, Ginevri F, Beatini M, Bertocchi M, Bonifazio L, Saltalamacchia L, Ghinolfi D, Perfumo F, Valente U. Impact of pretransplant dialysis on early graft function in pediatric kidney recipients. Transpl Int. 2005;18:785–93.

    Article  PubMed  Google Scholar 

  7. Groothoff JW. Long-term outcomes of children with end-stage renal disease. Pediatr Nephrol. 2005;20:849–53.

    Article  CAS  PubMed  Google Scholar 

  8. Seikaly MG, Salhab N, Browne R. Patterns and time of initiation of dialysis in US children. Pediatr Nephrol. 2005;20:982–8.

    Article  PubMed  Google Scholar 

  9. van Stralen KJ, Tizard EJ, Jager KJ, et al. Determinants of eGFR at start of renal replacement therapy in paediatric patients. Nephrol Dial Transplant. 2010;25(10):3325–32.

    Article  PubMed  Google Scholar 

  10. Vanholder R, Van Laecke S, Glorieux G. What is new in uremic toxicity? Pediatr Nephrol. 2008;23(8):1211–21.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Hothi D. Designing technology to meet the therapeutic demands of acute renal injury in neonates and small infants. Pediatr Nephrol. 2014;29:1869.

    Article  PubMed  Google Scholar 

  12. Hothi DK, Stronach L, Harvey E. Home haemodialysis. Pediatr Nephrol. 2013;28:721–30.

    Article  PubMed  Google Scholar 

  13. http://www.renal.org/guidelines/modules/haemodialysis#f3

  14. Goldstein SL, Leung JC, Silverstein DM. Pro- and anti-inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin. Clin J Am Soc Nephrol. 2006;1:979–86.

    Article  CAS  PubMed  Google Scholar 

  15. Saran R, Bragg-Gresham JL, Levin NW, Twardowski ZJ, Wizemann V, Saito A, Kimata N, Gillespie BW, Combe C, Bommer J, Akiba T, Mapes DL, Young EW, Port FK. Longer treatment time and slower ultrafiltration in hemodialysis: associations with reduced mortality in the DOPPS. Kidney Int. 2006;69:1222–8.

    Article  CAS  PubMed  Google Scholar 

  16. Springel T, Laskin B, Shults J, Keren R, Furth S. Longer interdialytic interval and cause-specific hospitalization in children receiving chronic dialysis. Nephrol Dial Transplant. 2013;28(10):2628–36.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Müller D, Zimmering M, Chan CT, McFarlane PA, Pierratos A, Querfeld U. Intensified hemodialysis regimens: neglected treatment options for children and adolescents. Pediatr Nephrol. 2008;23:1729–36.

    Article  PubMed  Google Scholar 

  18. Goldstein SL, Silverstein DM, Leung JC, Feig DI, Soletsky B, Knight C, Warady BA. Frequent hemodialysis with NxStagetrade mark system in pediatric patients receiving maintenance hemodialysis. Pediatr Nephrol. 2008;23:129–35.

    Article  PubMed  Google Scholar 

  19. Geary DF, Piva E, Tyrrell J, Gajaria MJ, Picone G, Keating LE, Harvey EA. Home nocturnal hemodialysis in children. J Pediatr. 2005;147:383–7.

    Article  PubMed  Google Scholar 

  20. Fischbach M, Terzic J, Menouer S, Dheu C, Soskin S, Helmstetter A, Burger MC. Intensified and daily hemodialysis in children might improve statural growth. Pediatr Nephrol. 2006;21:1746–52.

    Article  PubMed  Google Scholar 

  21. Hothi DK, Harvey E, Piva E, Keating L, Secker D, Geary DF. Calcium and phosphate balance in adolescents on home nocturnal haemodialysis. Pediatr Nephrol. 2006;21:835–41.

    Article  PubMed  Google Scholar 

  22. de Camargo MF, Henriques CL, Vieira S, Komi S, Leão ER, Nogueira PC. Growth of children with end-stage renal disease undergoing daily hemodialysis. Pediatr Nephrol. 2014;29(3):439–44.

    Article  PubMed  Google Scholar 

  23. Thumfart J, Puttkamer CV, Wagner S, Querfeld U, Müller D. Hemodiafiltration in a pediatric nocturnal dialysis program. Pediatr Nephrol. 2014;29(8):1411–6.

    Article  PubMed  Google Scholar 

  24. Jain SR, Smith L, Brewer ED, Goldstein SL. Non-invasive intravascular monitoring in the pediatric haemodialysis population. Pediatr Nephrol. 2001;16:15–8.

    Article  CAS  PubMed  Google Scholar 

  25. Davenport A. Alternatives to standard unfractionated heparin for pediatric hemodialysis treatments. Pediatr Nephrol. 2012;27(10):1869–79.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Hothi DK, Rees L, McIntyre CW, Marek J. Hemodialysis-induced acute myocardial dyssynchronous impairment in children. Nephron Clin Pract. 2013;123(1–2):83–92.

    Article  PubMed  Google Scholar 

  27. Penne EL, van der Weerd NC, Blankestijn PJ, van den Dorpel MA, Grooteman MP, Nube MJ, Ter Wee PM, Levesque R, Bots ML. Role of residual kidney function and convective volume on change in beta2-microglobulin levels in hemodiafiltration patients. Clin J Am Soc Nephrol. 2010;5:80–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  28. Chand DH, Brier M, Strife CF. Comparison of vascular access type in pediatric hemodialysis patients with respect to urea clearance, anemia management, and serum albumin concentration. Am J Kidney Dis. 2005;45:303–8.

    Article  PubMed  Google Scholar 

  29. Fischbach M, Edefonti A, Schröder C, Watson A, The European Pediatric Dialysis Working Group. Hemodialysis in children: general practical guidelines. Pediatr Nephrol. 2005;20:1054–66.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  30. Ma A, Shroff R, Hothi D, Lopez MM, Veligratli F, Calder F, Rees L. A comparison of arteriovenous fistulas and central venous lines for long-term chronic haemodialysis. Pediatr Nephrol. 2013;28(2):321–6.

    Article  PubMed  Google Scholar 

  31. Blaney M, Shen V, Kerner JA, Jacobs BR, Gray S, Armfield J, Semba CP, CAPS Investigators. Alteplase for the treatment of central venous catheter occlusion in children: results of a prospective, open-label, single-arm study (The Cathflo Activase Pediatric Study). J Vasc Interv Radiol. 2006;17(11 Pt 1):1745–51.

    Article  PubMed  Google Scholar 

  32. Bamgbola OF, del Rio M, Kaskel FJ, Flynn JT. Recombinant tissue plasminogen activator infusion for hemodialysis catheter clearance. Pediatr Nephrol. 2005;20:989–93.

    Article  PubMed  Google Scholar 

  33. Gittins NS, Hunter-Blair YL, Matthews JN, Coulthard MG. Comparison of alteplase and heparin in maintaining the patency of paediatric central venous haemodialysis lines: a randomised controlled trial. Arch Dis Child. 2007;92:499–501.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Cachat F, Bardy D, Durussel C, Di Paolo E. Spurious hyperphosphatemia in a patient with alteplase-locked central venous catheter. Pediatr Nephrol. 2006;21:301–2.

    Article  PubMed  Google Scholar 

  35. Ramage IJ, Bailie A, Tyerman KS, McColl JH, Pollard SG, Fitzpatrick MM. Vascular access survival in children and young adults receiving long-term hemodialysis. Am J Kidney Dis. 2005;45:708–14.

    Article  PubMed  Google Scholar 

  36. Gradman WS, Lerner G, Mentser M, Rodriguez H, Kamil ES. Experience with autogenous arteriovenous access for hemodialysis in children and adolescents. Ann Vasc Surg. 2005;19:609–12.

    Article  PubMed  Google Scholar 

  37. Dorsett-Martin WA. Review of microsurgery and arteriovenous fistulae for hemodialysis. Microsurgery. 2006;26:122–5.

    Article  PubMed  Google Scholar 

  38. Manook M, Calder F. Practical aspects of arteriovenous fistula formation in the pediatric population. Pediatr Nephrol. 2013;28:885–93.

    Article  PubMed  Google Scholar 

  39. Elsharawy MA, Moghazy KM. Impact of pre-operative venography on the planning and outcome of vascular access for hemodialysis patients. J Vasc Access. 2006;7:123–8.

    CAS  PubMed  Google Scholar 

  40. Ponikvar R. Surgical salvage of thrombosed arteriovenous fistulas and grafts. Ther Apher Dial. 2005;9:245–9.

    Article  PubMed  Google Scholar 

  41. Goldstein SL, Allsteadt A, Smith CM, Currier H. Proactive monitoring of pediatric hemodialysis vascular access: effects of ultrasound dilution on thrombosis rates. Kidney Int. 2002;62:272–5.

    Article  PubMed  Google Scholar 

  42. Sheth RD, Brandt ML, Brewer ED, Nuchtern JG, Kale AS, Goldstein SL. Permanent hemodialysis vascular access survival in children and adolescents with end-stage renal disease. Kidney Int. 2002;62:1864–9.

    Article  PubMed  Google Scholar 

  43. Maecken T, Grau T. Ultrasound imaging in vascular access. Crit Care Med. 2007;35(5 Suppl):S178–85.

    Article  PubMed  Google Scholar 

  44. Rees L, Bockenhauer D, Webb N, Brogan P. Haemodialysis. In: Rees L, Bockenhauer D, Webb N, Brogan P, editors. Handbook of paediatric nephrology. Oxford University Press; 2011

    Google Scholar 

  45. Onder AM, Chandar J, Coakley S, Abitbol C, Montane B, Zilleruelo G. Predictors and outcome of catheter-related bacteremia in children on chronic hemodialysis. Pediatr Nephrol. 2006;21:1452–8.

    Article  PubMed  Google Scholar 

  46. Onder AM, Chandar J, Saint-Vil M, Lopez-Mitnik G, Abitbol CL, Zilleruelo G. Catheter survival and comparison of catheter exchange methods in children on hemodialysis. Pediatr Nephrol. 2007;22:1355–61.

    Article  PubMed  Google Scholar 

  47. Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR. Hemodialysis catheter-related bacteremia in children: increasing antibiotic resistance and changing bacteriological profile. Am J Kidney Dis. 2007;50:119–23.

    Article  PubMed  Google Scholar 

  48. Gorman G, Furth S, Hwang W, Parekh R, Astor B, Fivush B, Frankenfield D, Neu A. Clinical outcomes and dialysis adequacy in adolescent hemodialysis patients. Am J Kidney Dis. 2006;47:285–93.

    Article  PubMed  Google Scholar 

  49. Juarez-Congelosi M, Orellana P, Goldstein SL. Normalized protein catabolic rate versus serum albumin as a nutrition status marker in pediatric patients receiving hemodialysis. J Ren Nutr. 2007;17:269–74.

    Article  PubMed  Google Scholar 

  50. Good practice guidelines for renal dialysis/transplantation units: prevention and control of blood-borne virus infection. Department of Health, 2002

    Google Scholar 

  51. Srivaths PR, Wong C, Goldstein SL. Nutrition aspects in children receiving maintenance hemodialysis: impact on outcome. Pediatr Nephrol. 2009;24:951–7.

    Article  PubMed Central  PubMed  Google Scholar 

  52. Rees L, Shaw V. Nutrition in children with CRF and on dialysis. Pediatr Nephrol. 2007;22:1689–702.

    Article  PubMed Central  PubMed  Google Scholar 

  53. National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI). Clinical practice Guideline for Nutrition in Children with CKD: 2008 update. Am J Kidney Dis. 2009;53(3 Suppl 2):S11.

    Article  Google Scholar 

  54. Rees L. Management issues in children with renal disease. In: Hodson E, Eddy A, editors. BMJ evidence based publications. BMJ; 2008.

    Google Scholar 

  55. Verrina E, Caruso U, Calevo MG, Emma F, Sorino P, De Palo T, Lavoratti G, Turrini Dertenois L, Cassanello M, Cerone R, Perfumo F, Italian Registry of Pediatric Chronic Dialysis. Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. Pediatr Nephrol. 2007;22:727–33.

    Article  PubMed  Google Scholar 

  56. Waller S, Shroff R, Freemont S, Rees L. Bone histomorphometry in children prior to commencing renal replacement therapy. Pediatr Nephrol. 2008;23:1523–9.

    Article  PubMed  Google Scholar 

  57. Moe S, Drüeke T, Cunningham J, Goodman W, Martin K, Olgaard K, Ott S, Sprague S, Lameire N, Eknoyan G, Kidney Disease: Improving Global Outcomes (KDIGO). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2006;69:1945–53.

    Article  CAS  PubMed  Google Scholar 

  58. Rees L. What parathyroid hormone levels should we aim for in children with stage 5 chronic kidney disease; what is the evidence? Pediatr Nephrol. 2008;23:179–84.

    Article  PubMed Central  PubMed  Google Scholar 

  59. http://www.kidney.org/professionals/kdoqi/guidelines_pedbone/index.htm

  60. Klaus G, Watson A, Edefonti A, Fischbach M, Rönnholm K, Schaefer F, Simkova E, Stefanidis CJ, Strazdins V, Vande Walle J, Schröder C, Zurowska A, Ekim M, European Podiatric Dialysis Working Group (EPDWG). Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines. Pediatr Nephrol. 2006;21:151–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  61. Borzych D, Rees L, Ha IS, Chua A, Valles PG, Lipka M, IPPN. The bone and mineral disorder of children undergoing chronic peritoneal dialysis. Kidney Int. 2010;78(12):1295–304.

    Article  PubMed  Google Scholar 

  62. Shroff RC, Donald AE, Hiorns MP, Watson A, Feather S, Milford D, Ellins EA, Storry C, Ridout D, Deanfield J, Rees L. Mineral metabolism and vascular damage in children on dialysis. J Am Soc Nephrol. 2007;18:2996–3003.

    Article  CAS  PubMed  Google Scholar 

  63. Shroff R, Egerton M, Bridel M, Shah V, Donald AE, Cole TJ, Rees L. A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol. 2008;19(6):1239–46.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  64. McDonald SP, Craig JC. Long-term survival of children with end-stage renal disease. N Engl J Med. 2004;350:2654–62.

    Article  CAS  PubMed  Google Scholar 

  65. Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32:S112–9.

    Article  CAS  PubMed  Google Scholar 

  66. Shroff R, Rees L, Trompeter R, Hutchinson C, Ledermann S. Long-term outcome of chronic dialysis in children. Pediatr Nephrol. 2005;21:257–64.

    Article  PubMed  Google Scholar 

  67. Mitsnefes MM. Cardiovascular complications of pediatric chronic kidney disease. Pediatr Nephrol. 2008;23:27–39.

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK

    Lesley Rees

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  1. Lesley Rees
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Correspondence to Lesley Rees .

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Editors and Affiliations

  1. Department of Pediatrics, Medical College of Wisconsin, Children’s Research Institute, Children’s Hospital, Health System of Wisconsin, Milwaukee, Wisconsin, USA

    Ellis D. Avner

  2. Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    William E. Harmon

  3. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Université Paris-Descartes, Paris, France

    Patrick Niaudet

  4. Department of Pediatrics, Wakayama Medical University, Wakayama City, Japan

    Norishige Yoshikawa

  5. Division of Nephrology, Bambino Gesù Children’s Hospital – IRCCS, Rome, Italy

    Francesco Emma

  6. Division of Nephrology and Hypertension, The Heart Institute, Cincinnati Children’s Hospital Medical Center, College of Medicine, Cincinnati, Ohio, USA

    Stuart L. Goldstein

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Rees, L. (2016). Hemodialysis in Children. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N., Emma, F., Goldstein, S. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43596-0_63

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  • DOI: https://doi.org/10.1007/978-3-662-43596-0_63

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