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Circadian variations in the effects of cardiovascular active drugs

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Predisposing Conditions for Acute Ischemic Syndromes

Abstract

It is now well established that all functions of the cardiovascular system display significant circadian variations (for review see [13–15]). Actually, biological rhythms in heart rate and blood pressure were described at the end of the 18th and the beginning of the 19th centuries. Falconer in 1797 described periodicities in pulse rate and mentioned that “the pulse, even in the state of perfect health, varies considerably at different times of day” [8]. Similarly, in 1801, Autenrieth described in his “Handbuch der empirischen menschlichen Physiologie” that the pulse was slower in the morning than in the evening and that daily changes occurred also in body temperature [4]. A daily variability in blood pressure was reported by Zadek in 1881 [35] and by Hill in 1898 [10]. Following these early reports, numerous more sophisticated studies have provided additional convincing evidence for circadian rhythms in heart rate and in systolic and diastolic blood pressure, both in healthy subjects and in patients suffering from cardiovascular diseases (for review see [13–17]).

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Author information

Authors and Affiliations

  1. Zentrum der Pharmakologie, J. W. Goethe-Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt/M 70, Germany

    Prof. Dr. med. Björn Lemmer

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  1. Prof. Dr. med. Björn Lemmer
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Editors and Affiliations

  1. I. Med. Klinik, Krankenanstalten Rotes Kreuz, Nymphenburger Str. 163, 8000, München 19, Germany

    Th. v. Arnim (Chefarzt) (Chefarzt)

  2. Cardiovascular Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, W12 OHS, London, UK

    A. Maseri

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© 1989 Springer-Verlag Berlin Heidelberg

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Lemmer, B. (1989). Circadian variations in the effects of cardiovascular active drugs. In: v. Arnim, T., Maseri, A. (eds) Predisposing Conditions for Acute Ischemic Syndromes. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-09434-1_1

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  • DOI: https://doi.org/10.1007/978-3-662-09434-1_1

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-662-09436-5

  • Online ISBN: 978-3-662-09434-1

  • eBook Packages: Springer Book Archive

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