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Neuronal Death by Accident or by Design pp 61–74Cite as

Normal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases

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Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Summary

Caspase inhibitors fail to prevent the programmed cell death (PCD) of developing motoneurons (MNs) in the chick embryo in ovo, and genetic deletion of upstream (caspase-9) or downstream (caspase-3) caspase family members in mice does not prevent the PCD of developing MNs or other populations of target-dependent post-mitotic neurons. Neurons undergoing PCD in the absence of caspases exhibit a non-apoptotic, often TUNEL-negative, mode of morphological degeneration. Loss of caspase activity may delay but does not prevent the quantitatively normal occurrence of neuronal PCD.

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Authors
  1. R. W. Oppenheim
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  2. C.-Y. Kuan
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  3. D. Prevette
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  4. P. Rakic
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  5. H. Yaginuma
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Editor information

Editors and Affiliations

  1. INSERM U.382 — IBDM (CNRS — INSERM — Univ. Méditerranée), Campus de Luminy, Case 907, 13288, Marseille Cedex 09, France

    Christopher E. Henderson Ph. D.

  2. Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, 92121, San Diego, CA, USA

    Douglas R. Green Ph. D.

  3. Institut des Neurosciences, UMR 7624, CNRS et Université Pierre et Marie Curie, 9 quai Saint Bernard, 75005, Paris, France

    Jean Mariani Ph. D.

  4. Pour la Recherche Thérapeutique, Fondation IPSEN, 24, rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen Ph. D.

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© 2001 Springer-Verlag Berlin Heidelberg

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Oppenheim, R.W., Kuan, CY., Prevette, D., Rakic, P., Yaginuma, H. (2001). Normal Programmed Cell Death of Developing Avian and Mammalian Neurons Following Inhibition or Genetic Deletion of Caspases. In: Henderson, C.E., Green, D.R., Mariani, J., Christen, Y. (eds) Neuronal Death by Accident or by Design. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04333-2_6

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  • DOI: https://doi.org/10.1007/978-3-662-04333-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-07517-9

  • Online ISBN: 978-3-662-04333-2

  • eBook Packages: Springer Book Archive

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