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Active Cell Death and Cancer

  • Conference paper
Apoptosis in Hormone-Dependent Cancers

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 14))

  • 46 Accesses

Abstract

Cancer development is a complex, multistage process in which failure of cell differentiation and proliferation control, for example, after activation of oncogenes, is considered to be an important causative factor. Relatively little attention has been paid to the role of cell death in cancer development, probably because for a long time in toxicology cell death was regarded as a passive degenerative phenomenon of secondary importance for the regulation of cell number in tissues. However, cell death is a biological phenomenon as important as cell proliferation. It serves to shape the final form of organisms during embryonic development and metamorphosis (Ellis et al. 1991; Glücksmann 1951; Lockshin and Williams 1964; Saunders 1966) and it counterbalances cell generation in adult tissues. Cell death is also a significant result of tissue damage and cause of disease (Farber et al. 1972; Kerr et al. 1972; Popper and Keppler 1986; Wyllie et al. 1980). Recently, new concepts have emerged related to the different types of cell death occurring in this wide variety of circumstances. In 1972 J. Kerr, A. Wyllie, and A. Currie proposed a classification of cell death into two broad categories. They introduced the concept of apoptosis to describe a form of active self-destruction of a cell which is under the control of the growth-regulating network and which — functionally speaking the opposite of mitosis — serves to downregulate the cell number in tissues (Kerr et al. 1972; Wyllie et al. 1980). According to this proposal, necrosis results from violent environmental perturbation, leading to rapid incapacitation of major cell functions (gene expression, ATP synthesis, membrane potential) and to the collapse of internal homeostasis. This concept eventually helped to elucidate the role of cell death in a variety of (patho)physiological states (Bursch et al. 1992; Fesus 1991; Korsmeyer 1992). Thus, during the past decades increasing evidence has accumulated showing that disturbance of apoptosis is involved in the pathogenesis of tumors (Bursch et al. 1992; Korsmeyer 1992; Sarraf and Bowen 1988; Vaux et al. 1988). Evidence for apoptosis was also found during regression of hormone-dependent tumors (Bursch 1994; Bursch et al. 1991; Gullino 1980; Kerr et al. 1972; Kyprianou et al. 1990, 1991; Lanzerotti and Gullino 1972; Szende et al. 1989, 1990). Thereby, the concept of apoptosis stimulated the development of new strategies for cancer treatment.

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  1. W. Bursch
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  2. B. Grasl-Kraupp
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  3. A. Ellinger
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  4. L. Török
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  6. L. Müllauer
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  7. R. Schulte-Hermann
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Editors and Affiliations

  1. W. Alton Jones Cell Science Center, 10 Old Barn Road, 12946, Lake Placid, NY, USA

    Martin Tenniswood

  2. Research Laboratories, Schering AG, Müllerstraße 170-178, 13342, Berlin, Germany

    Horst Michna

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© 1995 Springer-Verlag Berlin Heidelberg

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Bursch, W. et al. (1995). Active Cell Death and Cancer. In: Tenniswood, M., Michna, H. (eds) Apoptosis in Hormone-Dependent Cancers. Ernst Schering Research Foundation Workshop, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03122-3_5

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  • DOI: https://doi.org/10.1007/978-3-662-03122-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03124-7

  • Online ISBN: 978-3-662-03122-3

  • eBook Packages: Springer Book Archive

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