Abstract
In 1894, Binswanger was the first to describe subcortical arteriosclerotic encephalopathy (SAE), distinguishing it from the progressive paralysis of syphilis. SAE is frequently called Binswanger’s disease, recently also designated Binswanger’s microangiopathic leukoencephalopathy. The age at onset is usually between 50 and 70 years, but sometimes earlier or later on in life. SAE is a relatively common affliction of elderly patients, most of whom have risk factors for arteriosclerosis. It is clearly associated with a history of hypertension, although there are also reports of patients whose necropsy examinations reveal SAE but who did not have hypertension during life.
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© 1989 Springer-Verlag Berlin Heidelberg
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Valk, J., van der Knaap, M.S. (1989). Subcortical Arteriosclerotic Encephalopathy. In: Magnetic Resonance of Myelin, Myelination, and Myelin Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02568-0_45
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DOI: https://doi.org/10.1007/978-3-662-02568-0_45
Publisher Name: Springer, Berlin, Heidelberg
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