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Clinical Pharmacology of Anti-Epileptic Drugs pp 262–273Cite as

Absorption and Protein Binding in Serum of Several Anti-Epileptic Drugs

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Abstract

The absorption of a drug depends on several factors such as lipid solubility, pH of the media in which the drug is dissolved, its solubility in the media and its concentration. These factors are often modified by the formulation of the drugs. The chemical form employed, the particle size, the filler and masking agents used, and the tablet hardness, may have a marked effect on the absorption of drugs from the gastrointestinal tract (Dill et al., 1956; Eadie et al., 1968; Rail, 1968; Tyrer et al., 1970; Glazko and Chang, 1972; Lund, 1974).

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Authors and Affiliations

  1. National Hospital for Epileptics, Sandvika, Norway

    S. I. Johannessen & R. E. Strandjord

Authors
  1. S. I. Johannessen
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  2. R. E. Strandjord
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Editor information

Editors and Affiliations

  1. Neurophysiol. Abtlg., Ges. f. Epilepsie-Fschg. e. V., 48 Bielefeld 13, Bethel, Maraweg 13, Germany

    H. Schneider

  2. Abteilung für Neurologie im Klinikum Charlottenburg, Freien Universität Berlin, Spandauer Damm 130, D-l, Berlin 19 (West), Germany

    D. Janz

  3. Exeter & Mid-Devon Hospitals, Royal Devon & Exeter Hospitals (Wonford), Barrack Road, EX2 5DW, Exeter, England

    C. Gardner-Thorpe M. D.

  4. Instituut voor Epilepsiebestrijding, Achterweg 5, Heemstede, The Netherlands

    H. Meinardi Ph. D.

  5. Montreal Neurological Institute, 3801 University Street, Montreal 112, Quebec, Canada

    A. L. Sherwin Ph. D.

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© 1975 Springer-Verlag Berlin-Heidelberg

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Johannessen, S.I., Strandjord, R.E. (1975). Absorption and Protein Binding in Serum of Several Anti-Epileptic Drugs. In: Schneider, H., Janz, D., Gardner-Thorpe, C., Meinardi, H., Sherwin, A.L. (eds) Clinical Pharmacology of Anti-Epileptic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85921-2_27

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  • DOI: https://doi.org/10.1007/978-3-642-85921-2_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85923-6

  • Online ISBN: 978-3-642-85921-2

  • eBook Packages: Springer Book Archive

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