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Clinical Pharmacology of Anti-Epileptic Drugs pp 181–188Cite as

A Preliminary Study of Serum Carbamazepine Levels in Healthy Subjects and in Patients with Epilepsy

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Abstract

The medical treatment of epilepsy has been significantly improved by adjusting the dose of anti-epileptic drugs to the therapeutic range of serum levels (Buchthal et al., 1960, 1968; Lund et al., 1971; Penry et al., 1972). For carbamazepine, however, the therapeutic range in serum has not yet been established although different methods for determination of the drug have been available (Führ, 1964; Scheiffarth et al., 1966; Larsen et al., 1969; Nielsen and Remmer, 1969; Christiansen, 1971 a; Kupferberg, 1972). Furthermore, little is known about the pharmacokinetics of this drug in man (Winter Research Laboratories, 1968; Meinardi, 1972; Cereghino et al., 1973), especially the relation between serum and cerebrospinal fluid concentrations (Johannessen and Strandjord, 1971; Meinardi, 1972; Johannessen and Strandjord, 1973).

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Authors and Affiliations

  1. National Hospital for Epileptics, Sandvika, Norway

    R. E. Strandjord & S. I. Johannessen

Authors
  1. R. E. Strandjord
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  2. S. I. Johannessen
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Editor information

Editors and Affiliations

  1. Neurophysiol. Abtlg., Ges. f. Epilepsie-Fschg. e. V., 48 Bielefeld 13, Bethel, Maraweg 13, Germany

    H. Schneider

  2. Abteilung für Neurologie im Klinikum Charlottenburg, Freien Universität Berlin, Spandauer Damm 130, D-l, Berlin 19 (West), Germany

    D. Janz

  3. Exeter & Mid-Devon Hospitals, Royal Devon & Exeter Hospitals (Wonford), Barrack Road, EX2 5DW, Exeter, England

    C. Gardner-Thorpe M. D.

  4. Instituut voor Epilepsiebestrijding, Achterweg 5, Heemstede, The Netherlands

    H. Meinardi Ph. D.

  5. Montreal Neurological Institute, 3801 University Street, Montreal 112, Quebec, Canada

    A. L. Sherwin Ph. D.

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© 1975 Springer-Verlag Berlin-Heidelberg

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Strandjord, R.E., Johannessen, S.I. (1975). A Preliminary Study of Serum Carbamazepine Levels in Healthy Subjects and in Patients with Epilepsy. In: Schneider, H., Janz, D., Gardner-Thorpe, C., Meinardi, H., Sherwin, A.L. (eds) Clinical Pharmacology of Anti-Epileptic Drugs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85921-2_17

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  • DOI: https://doi.org/10.1007/978-3-642-85921-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85923-6

  • Online ISBN: 978-3-642-85921-2

  • eBook Packages: Springer Book Archive

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