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Tetanus and Botulinum Neurotoxins

  • Chapter
Selective Neurotoxicity

Part of the book series: Springer Study Edition ((SSE,volume 102))

Abstract

Tetanus toxin and the botulinum toxins A, B, Cl, D, E, F, and G are proteins produced by bacilli of the genus Clostridium. The eight toxins have a similar structure, they are translocated into neurons by adsorptive endocytosis, and they act predominantly on nerve cells. They have so many features in common (van Heyningen 1982; Mellanby 1984; Simpson 1990) that a comparative discussion not only appears to be justified but may contribute to a better understanding of the whole group of “clostridial neurotoxins” (CNTs).

Work supported by the Deutsche Forschungsgemeinschaft.

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  1. H. H. Wellhöner
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  1. Institut für Pharmakologie, Freien Universität, Thielallee 69/73, 14195, Berlin, Germany

    Hans Herken

  2. Institut für Biochemie, Freien Universität, Thielallee 63, 14195, Berlin, Germany

    Ferdinand Hucho

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Wellhöner, H.H. (1994). Tetanus and Botulinum Neurotoxins. In: Herken, H., Hucho, F. (eds) Selective Neurotoxicity. Springer Study Edition, vol 102. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85117-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-85117-9_11

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