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Second Malignant Neoplasms in Operable Carcinoma of the Breast

  • Chapter
Adjuvant Chemotherapy of Breast Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 96))

Abstract

Development of a second malignant neoplasm (SMN) following prolonged cytotoxic therapy is a potential delayed consequence of tumor treatment [1, 5, 6, 20, 26, 27, 31, 34, 46, 48, 49, 51]. In addition, specified primary neoplasms are associated with the development of other primary malignancies through either a common etiology or an impaired patient’s defense mechanism [44]. The oncogenic potential of adjuvant chemotherapy in early breast cancer may, therefore, best be analyzed by looking at the occurrence of SMNs in prospective randomized trials using a similar, nontreated patient population (surgical control). This report summarizes the frequency of SMNs in five controlled adjuvant chemotherapy trials and two studies with no surgical control group.

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Authors and Affiliations

  1. Division für Onkologie und Hämatologie, Abteilung für Medizin C, Kantonsspital, 9007, St. Gallen, Switzerland

    E. E. Holdener, R. Nissen-Meyer, G. Bonadonna, S. E. Jones, A. Howell, R. Rubens & H. J. Senn

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  1. E. E. Holdener
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  2. R. Nissen-Meyer
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  3. G. Bonadonna
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  4. S. E. Jones
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  5. A. Howell
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  6. R. Rubens
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  7. H. J. Senn
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Editors and Affiliations

  1. Medizinische Klinik C, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland

    Hans-Jörg Senn

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© 1984 Springer-Verlag Berlin · Heidelberg

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Holdener, E.E. et al. (1984). Second Malignant Neoplasms in Operable Carcinoma of the Breast. In: Senn, HJ. (eds) Adjuvant Chemotherapy of Breast Cancer. Recent Results in Cancer Research, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82357-2_24

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  • DOI: https://doi.org/10.1007/978-3-642-82357-2_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82359-6

  • Online ISBN: 978-3-642-82357-2

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