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Therapeutic Effect of Tamoxifen Alone Versus Tamoxifen in Combination with Gestagen and Oestrogen in Advanced Breast Cancer

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Endocrine Treatment of Breast Cancer

Abstract

The treatments used in postmenopausal women with advanced breast cancer include additive endocrine therapy. Due to the same or better efficacy as with other preparations and to the mild side effects, most authors now believe that the anti-oestrogen compound tamoxifen (TAM) is the drug of choice when additive endocrine treatment is indicated (Mouridsen et al., 1978; Tagnon, 1977).

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References

  • Ansfield, F. J., Davis, H. C., Jr., Ellerby, R. A., Ramireg, G.: A clinical trial of megesterol acetate in advanced breast cancer. Cancer 33, 907–910 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Barnes, D. M., Ribeiro, G. G., Skinner, L. G.: Two methods of measurements of oestradiol-17β and progesterone receptors in human breast cancer and correlation with response to treatment Eur. J. Cancer 13, 1133–1145 (1977)

    PubMed  CAS  Google Scholar 

  • Dæhnfeldt, J. L., Briand, P.: Determination of high affinity gestagen receptors in hormone responsive and hormone-independent GR mouse mammary tumors by an exchange assay. In: Progesterone receptors in normal and neoplastic tissues. McGuire, W. L., Raynaud, J.-P., Baulieu, E.-E. (eds.), p. 59. New York: Raven Press 1977

    Google Scholar 

  • Goldenberg, I. S.: Clinical trials of testolactone, medroxy-progesterone-acetate and oxylone acetate in advanced female mammary cancer. A report of The Cooperative Breast Cancer Group. Cancer 23, 109–111 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Hayward, J.: Hormones and human breast cancer. Recent results in cancer research. Berlin, Heidelberg, New York: Springer 1970

    Google Scholar 

  • Hayward, J. L., Carbone, P. P., Heuson, J.-C., Kumaoka, S., Segaloff, A., Rubens, R. D.: Assessment of response to therapy in advanced breast cancer. Eur. J. Cancer 13, 89–94 (1977)

    Google Scholar 

  • Hsueh, A. J. W., Peck, E. J., Clark, J. H.: Progesterone antagonism of the estrogen receptor and estrogen-induced uterine growth. Nature 254, 337–339 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Hsueh, A. J. W., Peck, E. J., Clark, J. H.: Control of uterine estrogen receptor levels by progesterone. Endocrinologia 98, 438–444 (1976)

    Article  CAS  Google Scholar 

  • Kiang, D. T., Kennedy, B. J.: Tamoxifen (antiestrogen) therapy in advanced breast cancer. Ann. Intern. Med. 87, 687–690 (1977)

    PubMed  CAS  Google Scholar 

  • King, J. B.: Clinical relevance of steroid-receptor measurements in tumors. Cancer Treat. Rev. 2, 273–295 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Koseki, Y., Zava, D. T., Chamness, G. G., McGuire, W. L.: Estrogen receptor translocation and replenishment by the antiestrogen tamoxifen. Endocrinologia 101, 1104–1110 (1977)

    Article  CAS  Google Scholar 

  • Leclercq, G., Heuson, J.-C.: Therapeutic significance of sexsteroid hormone receptors in the treatment of breast cancer. Eur. J. Cancer 13, 1205–1217 (1977)

    PubMed  CAS  Google Scholar 

  • Lippman, M.: Hormone-responsive human breast cancer in continuous tissue culture. In: Breast cancer: trends in research and treatment. Heuson, J.-C., Mattheiem, W. H., Rozencweig, M. (eds.), p. 111. New York: Raven Press 1976

    Google Scholar 

  • Manni, A., Trujillo, J., Marshall, J. S., Pearson, O. H.: Antiestrogen-induced remissions in stage IV breast cancer. Cancer Treat. Rep. 60, 1445–1450 (1976)

    PubMed  CAS  Google Scholar 

  • McGuire, W. L., Horwitz, K. B.: A role for progesterone in breast cancer. Ann. N.Y. Acad. Sci. 286, 90–100 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Milgrom, E., Luu This, M., Atger, M., Baulieu, E. E.: Mechanisms regulating the concentration and the conformation of progesterone receptors in the uterus. J. Biol. Chem. 248, 6366–6374 (1973)

    PubMed  CAS  Google Scholar 

  • Moseson, D. L., Sasaki, G. H., Kraybill, W. G., Leung, B. S., Davenport, C. E., Fletcher, W. S.: The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values. A phase II study. Cancer 41, 797–800 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Mouridsen, H. T., Palshof, T., Patterson, J., Battersby, L.: Tamoxifen in advanced breast cancer. Cancer Treat. Rev. 5, 131–141 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Muggia, F. M., Cassileth, P. A., Ochoa, Jr., M., Flatow, F. A., Gellhorn, A., Hyman, G. A.: Treatment of breast cancer with medroxyprogesterone-acetate. Ann. Intern. Med. 68, 328–337 (1968)

    PubMed  CAS  Google Scholar 

  • Nicholson, R. I., Golder, M. P., Davies, P., Griffiths, K.: Effects of estradiol-17/3 and tamoxifen on total and accessible cytoplasmic estradiol-17β receptors in DMBA-induced rat mammary tumors. Eur. J. Cancer 12, 711–717 (1976)

    PubMed  CAS  Google Scholar 

  • Palshof, T., Mouridsen, H. T., Dæhnfeldt, J.: Adjuvant endocrine therapy of breast cancer in premenopausal (placebo versus tamoxifen) and postmenopausal (placebo versus tamoxifen versus diethylstilboestrol) subjects In: Endocrine treatment of breast cancer. A new approach. Henningsen, B., Linder, F., Steichele, C. (eds.). Berlin, Heidelberg, New York: Springer 1980

    Google Scholar 

  • Pannuti, F., Martoni, A., Lenaz, G. R., Piana, E., Nanni, P.: Management of advanced breast cancer with medroxyprogesteroneacetate (NSC 26386) in high doses. Functional exploration of serology, pp. 253–256 (1976)

    Google Scholar 

  • Segaloff, A., Cuningham, M., Rice, B. F., Weeth, J. B.: Hormonal therapy in cancer of the breast. XIV — effect of corticosterone or medroxyprogesterone-acetate on the clinical course and hormonal excretion. Cancer 20, 1673–1688 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Stoll, B.: Progestin therapy of breast cancer: Comparison of agents. Br. Med. J. 1967a III, 338–341

    Article  Google Scholar 

  • Stoll, B.: Vaginal cytology as an aid to hormone therapy in postmenopausal cancer of the breast. Cancer 20, 1807–1813 (1967b)

    Article  CAS  Google Scholar 

  • Tagnon, H. J.: Antiestrogens in the treatment of breast cancer. Cancer 39, 2959–2964 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Tormey, D. C., Simon, R. M., Lippman, M. E., Bull, J. M., Myers, C. E.: Evaluation of tamoxifen dose in advanced breast cancer: A progress report. Cancer Treat. Rep. 60, 1451–1459 (1976)

    PubMed  CAS  Google Scholar 

  • Ward, H. W. C.: Combined antiprolactin and antiestrogen therapy for breast carcinoma. Clin. Oncol. 3, 91–95 (1977)

    PubMed  CAS  Google Scholar 

  • Wulf, H. R.: Confidence limits in evaluating controlled therapeutic trials. Lancet 1973 II, 969

    Article  Google Scholar 

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Mouridsen, H.T., Palshof, T., Rose, C. (1980). Therapeutic Effect of Tamoxifen Alone Versus Tamoxifen in Combination with Gestagen and Oestrogen in Advanced Breast Cancer. In: Henningsen, B., Linder, F., Steichele, C. (eds) Endocrine Treatment of Breast Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 71. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81406-8_26

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  • DOI: https://doi.org/10.1007/978-3-642-81406-8_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81408-2

  • Online ISBN: 978-3-642-81406-8

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