Abstract
Quantitative computed tomography (QCT) is an established technique for measuring bone mineral density (BMD) in the axial spine and appendicular skeleton [1–3]. Because it provides cross-sectional images, QCT is uniquely able to provide separate measurements of trabecular and cortical bone BMD as well as a true volumetric mineral density in grams per cubic centimeter. In this application QCT has been used for assessment of vertebral fracture risk [4, 5], measurement of age-related bone loss [6–8], and follow-up of osteoporosis and other metabolic bone diseases [9]. This chapter assesses the current capabilities of QCT at different skeletal sites, and reviews recent technical developments such as fast three-dimensional data acquisition and high-resolution image acquisition and processing techniques, in which novel information about bone strength may be obtained through analysis of trabecular microarchitecture.
Keywords
- Bone Mineral Density
- Vertebral Fracture
- Quantitative Compute Tomography
- Vertebral Fracture Risk
- Trabecular Bone Mineral Density
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Genant HK, Cann CE, Ettinger B, Gordan GS (1982) Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97: 699–705
Guglielmi G, Glüer CC, Majumdar S, Blunt BA, Genant HK (1995) Current methods and advances in bone densitometry. Eur Radiol 5: 129–139
Rüegsegger P, Elsasser U, Anliker M, Gnehm H, Kind H, Prader A (1976) Quantification of bone mineralization using computed tomography. Radiology 121: 93–97
Cann CE, Genant HK (1980) Precise measurement of vertebral mineral content using computed tomography. J Comput Assist Tomogr 4: 493–500
Pacifici R, Rupich R, Griffin M, Chines A, Susman N, Avioli LV (1990) Dual energy radiography versus quantitative computed tomography for the diagnosis of osteoporosis. J Clin Endocrinol Metab 70: 705–710
Guglielmi G, Grimston SK, Fisher KC, Pacifici R (1994) Osteoporosis: diagnosis with lateral and posteroanterior dual X-ray absorptiometry compared with quantitative CT. Radiology 192: 845–850
Block JE, Smith R, Glüer CC, Steiger P, Ettinger B, Genant HK (1989) Models of spinal trabecular bone loss as determined by quantitative computed tornograhy. J Bone Miner Res 4: 249–257
Kalender WA, Klotz E, Süss C (1987) Vertebral bone mineral analysis: an integrated approach. Radiology 164: 419–423
Genant HK, Steiger P, Block JE, Glüer CC (1987) Quantitative computed tomography: update 1987. Calcif Tissue Int 41: 179–186
Genant HK, Block JE, Steiger P, Glüer CC (1987) Quantitative computed tomography in the assessment of osteoporosis. In: Genant HK (ed) Osteoporosis update 1987. University of California Press, Berkeley, pp 49–71
Firooznia H, Golimbu C, Rafii M, Schwartz MS, Alterman ER (1984) Quantitative computed tomography assessment of spinal trabecular bone: II. In osteoporotic women with and without vertebral fractures. J Comput Tomo-gr 8: 99–103
Genant HK, Glüer CC, Steiger P, Faulkner KG (1992) Quantitative computed tomography for the assessment of osteoporosis. In: Moss AA, Gamsu G, Genant HK (eds) Computed tomography of the body. Saunders, Philadelphia, pp 523–549
Kalender WA, Brestowsky H, Felsenberg D (1988) Bone mineral measurements: automated determination of the midvertebral CT section. Radiology 168: 219–221
Steiger P, Block JE, Steiger S, Heuck A, Friedlander A, Ettinger B, Harris ST, Glüer CC, Genant HK (1990) Spinal bone mineral density by quantitative computed tomography: effect of region of interest, vertebral level, and technique. Radiology 175: 537–543
Guglielmi G, Giannatempo GM, Blunt BA, Grampp S, Glüer CC, Cammisa M, Genant HK (1995) Spinal bone mineral density by quantitative computed tomography in a normal Italian population. Eur Radiol 5: 269–275
Cann CE (1987) QCT applications: comparison of current scanners. Radiology 162: 257–261
Boden SD, Goodenough DJ, Stockham CD, Jacobs E, Dina T, Allman RM (1989) Precise measurement of vertebral bone density using computed tomography without the use of an external reference phantom. J Digit Imag 2: 31–38
Gudmundsdottir H, Jonsdottir B, Kristinsson S, Johanesson A, Goodenough DJ, Sigurdsson G (1993) Vertebral bone density in Icelandic women using quantitative computed tomography without an external reference phantom. Osteoporos Int 3: 84–89
Suzuki S, Yamamuro T, Okumura H, Yamamoto I (1991) Quantitative computed tomography: comparative study using different scanners with two calibration phantoms. Br J Radiol 64: 1001–1006
Goodsitt MM (1992) Conversion relations for quantitative CT bone mineral density measured with solid and liquid calibration standards. Bone Miner 19: 145–148
Faulkner KG, Glüer CC, Grampp S, Genant HK (1993) Cross calibration of liquid and solid QCT calibration standards: corrections to UCSF normative data. Osteoporos Int 3: 36–43
Glüer CC, Engelke K, Jergas M, Hagiwara S, Grampp S, Genant HK (1993) Changes in calibration standards for quantitative computed tomography: recommendations for clinical practice. Osteoporos Int 3: 286–287
Genant HK, Boyd DP (1977) Quantitative bone mineral analysis using dual energy computed tomography. Invest Radiol 12: 545–551
Cann CE, Genant HK (1983) Single versus dual-energy CT for vertebral mineral quantification. J Comput Assist Tomogr 7: 551–552
Laval-Jeantet AM, Roger B, Bouysse S, Bergot C, Mazess RB (1986) Influence of vertebral fat content on quantitative CT density. Radiology 159: 463–466
Glüer CC, Genant HK (1989) Impact of marrow fat on accuracy of quantitative CT. J Comput Assist Tomogr 13: 1023–1035
Reinbold WD, Genant HK, Reiser UJ, Harris ST, Ettinger B (1986) Bone mineral content in early-postmenopausal osteoporotic women and postmenopausal women: comparison of measurements methods. Radiology 160: 469–478
Glüer CC, Reiser UJ, Davis CA, Rutt BK, Genant HK (1988) Vertebral mineral determination by quantitative computed tomography (QCT): accuracy of single and dual energy measurements. J Comput Assist Tomogr 12: 242–258
Pacifici R, Susman N, Carr PL, Birge SJ, Avioli LV (1987) Single and dual energy tomography analysis of spinal trabecular bone: a comparative study in normal and osteoporotic women. J Clin Endocrinol Metab 64: 209–214
Reinbold WD, Adler CP, Kalender WA, Lente R (1991) Accuracy of vertebral mineral determination by dual-energy quantitative computed tomography. Skel Radiol 20: 25–29
Cann CE, Genant HK, Kolb FO, Ettinger B (1985) Quantitative computed tomography for prediction of vertebral fracture risk. Bone 6: 1–7
Heuck A, Block J, Glüer CC, Steiger P, Genant HK (1989) Mild versus definitive osteoporosis: comparison of bone densitometry techniques using different statistical models. J Bone Miner Res 4: 891–899
Sambrook P, Barlett C, Evans R, Hesp R, Katz D, Reeve J (1985) Measurements of lumbar spine bone mineral: a comparison of dual photon absorptiometry and computed tomography. Br J Radiol 58: 621–624
Ross PD, Genant HK, Davis JW, Wasnich RD (1993) Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int 3: 120–126
Larnach TA, Boyd SJ, Smart RC, Butler SP, Rohl PG, Diamond TH (1992) Reproducibility of lateral spine scans using dual energy X-ray absorptiometry. Cal-cif Tissue Int 51: 255–258
Rupich R, Pacifici R, Griffin MG, Vered I, Susman N, Avioli LV (1990) Lateral dual energy radiography: a new method for measuring vertebral bone density: a preliminary study. J Clin Endocrinol Metab 70: 1768–1770
Slosman DO, Rizzoli R, Donath A, Bonjour JP (1990) Vertebral bone mineral density measured laterally by dual-energy X-ray absorptiometry. Osteoporos Int 1: 23–29
Reid IR, Evans MC, Stapleton J (1992) Lateral spine densitometry is a more sensitive indicator of glucocorticoid-induced bone loss. J Bone Miner Res 7: 1221–1225
Yu W, Glüer CC, Grampp S, Jergas M, Fuerst T, Wu CY, LuY, Fan B, Genant HK (1995) Spinal bone mineral assessment in postmenopausal women: a comparison between dual X-ray absorptiometry and quantitative computed tomography. Osteoporos Int 5: 433–439
Cummings S, Marcus R, Palermo L, Ensrud K, Genant HK (1994) Does estimating volumetric bone density of the femoral neck improve the prediction of hip fracture? J Bone Miner Res 9: 1429–1432
Jergas M, Breitenseher M, Glüer CC,Yu W, Genant HK (1995) Estimates of volumetric bone density from projectional measurements improve the discriminatory capability of dual X-ray absorptiometry. J Bone Miner Res 10: 1101–1110
Heitz M, Kalender W (1994) Evaluation of femoral density and strength using volumetric CT and anatomical coordinate systems. Bone 25: S11
Sartoris DJ, Andre M, Resnick C, Resnick D (1986) Trabecular bone density in the proximal femur: quantitative CT assessment. Radiology 160: 707–712
Bhasin S, Sartoris DJ, Fellingham L, Zlatkin MB, Andre M, Resnick D (1988) Three-dimensional quantitative CT of the proximal femur: relationship to vertebral trabecular bone density in postmenopausal women. Radiology 167: 145–149
Lang T, Heitz M, Keyak J, Genant HK (1996) A 3D anatomic coordinate system for hip QCT. Osteoporos Int 6: S203
Esses SI, Lotz JC, Hayes WC (1989) Biomechanical properties of the proximal femur determined in vitro by single-energy quantitative computed tomography. J Bone Miner Res 4: 715–722
Alho A, Hoiseth A, Torstein H (1989) Bone-mass distribution in the femur. Acta Orthop Scand 60: 101–104
Smith M, Cody DD, Goldstein S, Cooperman A, Matthews L, Flynn M (1992) Proximal femoral density and its correlation to fracture load and hip-screw penetration load. Clin Orthop 283: 244–251
Lotz JC, Hayes WC (1990) Estimates of hip fracture risk from falls using quantitative computed tomography. J Bone Joint Surg Am 72: 689–700
Lang T, Augat P, Heitz M, Genant HK (1996) Volumetric QCT of the spine: comparison to single-slice QCT and DXA. J Bone Miner Res 11: 479
Cody DD (1991) Correlations between vertebral regional bone mineral density (rBMD) and whole bone fracture load. Spine 16: 146–154
Hangartner TN, Gilsanz V (1993) Measurement of cortical bone by computed tomography. Calcif Tissue Int 52: 160
Sandor T, Felsenberg D, Kalender W, Brown E (1991) Global and regional variations in the spinal trabecular bone: single and dual energy examinations. J Clin Endocrinol Metab 72: 1157–1168
Sandor T, Felsenberg D, Kalender W, Clain A, Brown E (1992) Compact and trabecular components of the spine using quantitative computed tomography. Calcif Tissue Int 50: 502–506
Cody DD, Flynn MJ, Vickers DS (1989) A technique for measuring regional bone mineral density in human lumbar vertebral bodies. Med Phys 16: 766–772
Flynn MJ, Cody DD (1993) The assessment of vertebral bone macroarchitecture with X-ray computed tomography. Calcif Tissue Int 53: S170–175
Braillon PM, Bochu M, Meunier PJ (1993) Quantitative computed tomography (QCT): a new analysis of bone quality in osteoporosis and osteomalacia. Calcif Tissue Int 52: 166
Engelke K, Grampp S, Glüer CC, Jergas M, Yang SO, Genant HK (1995) Significance of QCT bone mineral density and its standard deviation as parameters to evaluate osteoporosis. J Comput Assist Tomogr 19: 111–116
Chevalier F, Laval-Jeantet AM, Laval-Jeantet M, Bergot C (1992) CT image analysis of the vertebral trabecular network in vivo. Calcif Tissue Int 51: 8–13
Ito M, Ohki M, Hayashi K, Yamada M, Uetani M, Nakamura T (1995) Trabecular texture analysis of CT images in the relationship with spinal fracture. Radiology 194: 55–59
Wang X, Lang T, Heitz M, Ouyang X, Engelke K, Genant HK (1996) Comparison of spinal trabecular structure analysis and QCT spinal BMD: an in vivo, low-dose pilot study. J Bone Miner Res 11: S474
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Guglielmi, G., Lang, T.F., Cammisa, M., Genant, H.K. (1998). Quantitative Computed Tomography at the Axial Skeleton. In: Genant, H.K., Guglielmi, G., Jergas, M. (eds) Bone Densitometry and Osteoporosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80440-3_16
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DOI: https://doi.org/10.1007/978-3-642-80440-3_16
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