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Cellular Models for In Vitro Toxicity Testing

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Animal Cell Culture Techniques

Part of the book series: Springer Lab Manual ((SLM))

Abstract

Compared to other biomedical disciplines, cell culture systems have only recently been systematically adopted for use in toxicology (Paganuzzi Stammati et al. 1981), due, in particular, to the difficulty in extrapolating in vitro data to the in vivo situation for regulatory purposes. However, in the last decade, technological advancements using cell culture systems, together with the important results obtained in biomedical research, have impressively promoted its use in toxicology investigations. Growth factors and substrates able to stimulate cell proliferation and/or expression of specific highly specialized functions, and sophisticated analytical techniques for mechanistic studies, together with automated procedures, have played a pivotal role.

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Author information

Authors and Affiliations

  1. Istituto Tecnologie Biomediche, C.N.R, Via G. B. Morgagni 30/E, 00161, Rome, Italy

    Flavia Zucco

  2. Laboratorio di Tossicologia Comparata ed Ecotossicologia, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

    Isabella De Angelis & Annalaura Stammati

Authors
  1. Flavia Zucco
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  2. Isabella De Angelis
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  3. Annalaura Stammati
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Corresponding author

Correspondence to Flavia Zucco .

Editor information

Editors and Affiliations

  1. National Cell & Tissue Culture Center Bioresearch Ireland, Dublin City University, Glasnevin Dublin 9, Ireland

    Martin Clynes

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© 1998 Springer-Verlag Berlin Heidelberg

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Zucco, F., De Angelis, I., Stammati, A. (1998). Cellular Models for In Vitro Toxicity Testing. In: Clynes, M. (eds) Animal Cell Culture Techniques. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80412-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-80412-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63008-1

  • Online ISBN: 978-3-642-80412-0

  • eBook Packages: Springer Book Archive

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