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Dynamics of Bone Remodelling

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Modelling the Dynamics of Biological Systems

Part of the book series: Springer Series in Synergetics ((SSSYN,volume 65))

Abstract

The skeleton is formed during childhood through the constant influence of daily mechanical loading. Later, the skeleton is remodelled in order to renew bone tissue and reorganise bone structure. Bone remodelling is a dynamic process, with several types of cells working close together in time and space. It occurs in anatomically discrete sites, which are active for a few months and then rest for several years. During each remodelling process, some bone mass is lost, causing the normal age-related bone loss. The bone remodelling process mediates at any time the effect of both hormonal and mechanical agents that act on the skeleton. Different naturally-occurring events or therapeutic regimens can influence the activation frequency, the balance, and all phases of the remodelling process. This dynamic remodelling process can be simulated during normal aging, the menopause, and also during different therapeutic regimens. A simulation model thereby provides “non-invasive” information concerning the influence of the remodelling process on bone mass, architecture, and thereby bone strength — and it also provides a tool for evaluating existing and new regimens for the treatment of osteoporosis.

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Authors
  1. Li. Mosekilde
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  2. J. S. Thomsen
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  3. E. Mosekilde
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Editor information

Editors and Affiliations

  1. Physics Department, Technical University of Denmark, Building 309, DK-2800, Lyngby, Denmark

    Erik Mosekilde

  2. Department of Physical Chemistry, Technical University of Denmark, Building 206, DK-2800, Lyngby, Denmark

    Ole G. Mouritsen

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© 1995 Springer-Verlag Berlin Heidelberg

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Mosekilde, L., Thomsen, J.S., Mosekilde, E. (1995). Dynamics of Bone Remodelling. In: Mosekilde, E., Mouritsen, O.G. (eds) Modelling the Dynamics of Biological Systems. Springer Series in Synergetics, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79290-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-79290-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79292-2

  • Online ISBN: 978-3-642-79290-8

  • eBook Packages: Springer Book Archive

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