Skip to main content

Identification of Distinct Families of HD-ZIP Proteins in Arabidopsis Thaliana

  • Conference paper
Plant Molecular Biology

Part of the book series: NATO ASI Series ((ASIH,volume 81))

Abstract

Many of the regulatory genes involved in the control of development share a common sequence element of 180 bp, the homeobox (HB), which encodes a 60 amino acid motif, the homeodomain (HD; Scott et al., 1989; Gehring et al., 1990). The amino acid sequences of known HDs are conserved in evolution from yeast to higher vertebrates (Scott et al., 1989). Recently HB genes have been identified in two plant species, maize (Vollbrecht et al., 1991; Bellmann and Werr, 1992) and Arabidopsis (Ruberti et al., 1991). Despite the differences in plant and animal development the discovery of homeobox genes in plants suggests that fundamental regulatory mechanisms that control development may be shared among all higher eukaryotes. The analysis of the maize kn1 mutants has shown that ectopic expression of the knotted gene profoundly affects leaf development, suggesting that HD proteins in plants might be involved in differentiation and/or developmental control as they are in animals (Hake, 1992).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Affolter M, Schier A and Gehring WJ (1990) Homeodomain proteins and the regulation of gene expression. Current Opinion in Cell Biology 2: 485–495.

    Article  PubMed  CAS  Google Scholar 

  • Bellmann R and Werr W (1992) Zmhox 1A, the product of a novel maize homeobox gene, interacts with the Shrunken 26 bp feedback control element. Embo J 11: 3367–3374.

    PubMed  CAS  Google Scholar 

  • Carabelli M, Sessa G, Baima S, Morelli G and Ruberti I (1993) The Arabidopsis Athb-2 and -4 genes are strongly induced by far red rich light. Plant J in press.

    Google Scholar 

  • Chirgwin J M, Pzrybyla A E, McDonald R J and Rutter W J (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294–5299.

    Article  PubMed  CAS  Google Scholar 

  • Devereux J (1991) Program Manual, Sequence Analysis Software Package, Version 7, Genetics Computer Group, Madison.

    Google Scholar 

  • Ekker S C, Young K E, von Kessler D P and Beachy P A (1991) Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila. Embo J 11: 1179–1186.

    Google Scholar 

  • Feinberg A P and Vogelstein B (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132: 6–13.

    Article  PubMed  CAS  Google Scholar 

  • Florence B, Handrow R and Laughon A (1991) DNA-binding specificity of the fushi tarazu homeodomain. Mol Cell Biol 11: 3613–3623.

    PubMed  CAS  Google Scholar 

  • Furukubo-Tokunaga K, Muller M, Affolter M, Pick L, Kloter U and Gehring W J (1992) In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeodomain of Drosophila melanogaster. Genes & Dev 6: 1082–1096.

    Article  CAS  Google Scholar 

  • Gehring WJ, Muller M, Affolter M, Percival-Smith A, Billeter M, Qian Y Q, Otting G and Wuthrich K (1990) The structure of the homeodomain and its functional implications. Trends in Genetics 6: 323–329.

    Article  PubMed  CAS  Google Scholar 

  • Glover C V C III (1989) Sequence-specific protein-DNA recognition by trancriptional regulatory proteins. Plant Mol Biol Reporter 7 (3): 183–208.

    Article  CAS  Google Scholar 

  • Hake S (1992) Unraveling the knots in plant development. Trends in Genetics 8: 109–114.

    PubMed  CAS  Google Scholar 

  • Hayashi S and Scott M P (1990) What determines the specificity of action of Drosophila homeodomains proteins? Cell 63: 883–894.

    Article  PubMed  CAS  Google Scholar 

  • Laughon A (1991) DNA binding specificity of homeodomains. Biochemistry 30: 11357–11367.

    Article  PubMed  CAS  Google Scholar 

  • Manak J R and Scott P (1993) Able assistants for homeodomain proteins. Current Biol 3: 318–320.

    Article  CAS  Google Scholar 

  • Mattsson J, Soderman E, Svenson M, Borkird C and Engstrom P (1992) A new homeobox-leucine zipper gene from Arabidopsis thaliana. Plant Mol Biol 18: 1019–1022.

    Article  PubMed  CAS  Google Scholar 

  • Mattsson J, Soderman E, Svenson M and Engstrom P (1993) Tissue- and organ- specific expression of homeobox-containing genes from Arabidopsis thaliana and carrot. J Cell Biochem Sup 17B: 31.

    Google Scholar 

  • McGinnis W, Levine M, Hafen E, Kuroiwa A and Gehring W J (1984) A conserved DNA sequence in homeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature 308: 428–433.

    Article  PubMed  CAS  Google Scholar 

  • Ruberti I, Sessa G, Lucchetti S and Morelli G (1991) A novel class of plant proteins containing a homeodomain with a closely linked leucine zipper motif. Embo J 10: 1787–1791.

    PubMed  CAS  Google Scholar 

  • Schena M and Davis R W (1992) HD-Zip proteins: members of an Arabidopsis homeodomain protein superfamily. Proc Natl Acad Sci USA 89: 3894–3898.

    Article  PubMed  CAS  Google Scholar 

  • Schier F A and Gehring W J (1993) Analysis of a fushi tarazu autoregolatory element: multiple sequence elements contribute to enhancer activity. Embo J 12: 1111–1119.

    PubMed  CAS  Google Scholar 

  • Scott M P, Tamkun J W and Hartzell G W III (1989) The structure and function of the homeodomain. BBA Rev Cancer 989: 25–48.

    CAS  Google Scholar 

  • Sessa G, Morelli G and Ruberti I (1993) The Athb-1 and -2 HD-Zip domains homodimerize forming complexes of different DNA binding specificity. Embo J in press.

    Google Scholar 

  • Smith D L and Johnson A D (1992) A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomain of an α2 dimer. Cell 68: 133–142.

    Article  PubMed  CAS  Google Scholar 

  • Singh H, Sen R, Baltimore D and Sharp P A (1986) A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (London) 319: 154–158.

    Article  CAS  Google Scholar 

  • Thomas P S (1980) Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci USA 77: 5201–5205.

    Article  PubMed  CAS  Google Scholar 

  • Vollbrecht E, Veit B, Sinha N and Hake S (1991) The developmental gene Knotted-1 is a member of a maize homeobox gene family. Nature (London) 350: 241–243.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sessa, G., Carabelli, M., Ruberti, I., Lucchetti, S., Baima, S., Morelli, G. (1994). Identification of Distinct Families of HD-ZIP Proteins in Arabidopsis Thaliana . In: Coruzzi, G., Puigdomènech, P. (eds) Plant Molecular Biology. NATO ASI Series, vol 81. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78852-9_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78852-9_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78854-3

  • Online ISBN: 978-3-642-78852-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics