Abstract
Failing defense mechanisms against malignant tumors are thought to be caused by low immunogenicity of tumor cells and defective T helper cell functions. The concept of associate recognition by Lake and Mitchison [5] posits the necessity of at least two antigens being expressed to achieve a sufficient immune response against the cellular target. In vivo experiments show that expression of a viral antigen together with the putative tumor-associated antigen(s) not only triggers a strong immune response against itself but also remarkably improves immune response mechanisms against the tumor-associated antigen [6]. Local cytokine expression by tumor cells, on the other hand, bypasses a defective T helper function [2] and elicits an effective immune response against tumor cells in animal models [2, 3].
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© 1994 Springer-Verlag Berlin Heidelberg
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Schackert, G., Buttler, A., Mehrabi, A., Schackert, H.K., Herfarth, C., Kunze, S. (1994). Monocyte- and Lymphocyte-Mediated Cytotoxicity After Gene Transfer and Expression of Human Interleukin-2 in a Human Glioblastoma Cell Line. In: Bauer, B.L., Brock, M., Klinger, M. (eds) Cerebellar Infarct. Midline Tumors. Minimally Invasive Endoscopic Neurosurgery (MIEN). Advances in Neurosurgery, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78801-7_31
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DOI: https://doi.org/10.1007/978-3-642-78801-7_31
Publisher Name: Springer, Berlin, Heidelberg
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