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Anabolic Effects of Growth Hormone Administration in Adults

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Growth Hormone and Somatomedins during Lifespan

Abstract

The metabolic effects of human growth hormone (GH) administration in adults without GH deficiency have been well documented over the past 5 decades. Studies in the 1950s demonstrated nitrogen retention in burn patients (Prudden et al. 1956) and nitrogen, potassium, phosphorus, sodium and chloride retention in adult subjects given pituitary-derived GH (Ikkos et al. 1958).Classical nutrient balance studies clearly documented anabolic effects of pituitary GH in humans (Henneman et al. 1960 Henneman and Henneman 1960). Retention of cellular constituents (nitrogen, phosphorus, potassium, sodium, magnesium and calcium) occurred during GH treatment in non-GH deficient adults and also in children with presumed hypopituitarism. Nutrient retention occurred in proportions characteristic of lean tissue and bone (Henneman et al. 1960). Additionally, fat mobilization with elevated free fatty acids and associated glucose intolerance were observed with GH administration (Henneman and Henneman 1960). The metabolic and protein-anabolic effects of GH observed in adults were consistent with findings of stimulated linear growth and loss of body fat in children receiving GH (Collip et al. 1973; Henneman et al. 1960).

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Authors
  1. T. R. Ziegler
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  2. D. W. Wilmore
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Editors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy

    Eugenio E. Müller (Professor of Pharmacology) & Vittorio Locatelli (Associate Professor of Pharmacology) (Professor of Pharmacology) &  (Associate Professor of Pharmacology)

  2. Pharmaco-biological Institute, University of Bari, 70125, Bari, Italy

    Daniela Cocchi (Professor of Pharmacology) (Professor of Pharmacology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Ziegler, T.R., Wilmore, D.W. (1993). Anabolic Effects of Growth Hormone Administration in Adults. In: Müller, E.E., Cocchi, D., Locatelli, V. (eds) Growth Hormone and Somatomedins during Lifespan. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78217-6_27

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  • DOI: https://doi.org/10.1007/978-3-642-78217-6_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78219-0

  • Online ISBN: 978-3-642-78217-6

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