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The Contribution of Perturbed Epithelial-Mesenchymal Interactions to Cancer Pathogenesis

  • Conference paper
Endocrine Therapy of Breast Cancer V

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

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Abstract

Interactions between epithelial cells and fibroblasts play a central role in directing both the spatial and temporal pattern of differentiation during the course of embryonic development [1]. Such “epithelial-mesenchymal” interactions continue to modulate and integrate various diverse elements of cell behaviour in the adult [2]. The biochemical identity of the signal molecules mediating epithelial-mesenchymal interactions has been the subject of intense investigation. Grobstein [3] first speculated that insoluble components of the extracellular matrix (ECM) might be involved; this initial insight has been confirmed in subsequent studies and there is now a substantial literature indicating that ubiquitous matrix macromolecules (such as collagens and proteoglycans) influence a variety of fundamental cellular attributes. The mechanism by which the ECM exerts these different effects appears to depend upon the interaction of matrix macromolecules with specific cell surface receptors resulting in alterations in the organisation of the cytoskeleton and consequent changes in cell shape [4].

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Author information

Authors and Affiliations

  1. Department of Cell and Structural Biology, Stopford Building, University of Manchester, Manchester, M13 9PL, UK

    Seth L. Schor, Ann Marie Grey, Martino Picardo & Ian Ellis

  2. Cancer Research Fund, Department of Medical Oncology, Christie Hospital, Wilmslow Road, Manchester, M20 9BX, UK

    Ana M. Schor, Anthony Howell & Graham Rushton

Authors
  1. Seth L. Schor
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  2. Ana M. Schor
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  3. Anthony Howell
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  4. Ann Marie Grey
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  5. Martino Picardo
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  6. Ian Ellis
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  7. Graham Rushton
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Editor information

Editors and Affiliations

  1. Department of Medical Oncology, Ospedale Civico, via Tesserete 46, 6900, Lugano, Switzerland

    A. Goldhirsch

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© 1992 Springer-Verlag Berlin Heidelberg

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Schor, S.L. et al. (1992). The Contribution of Perturbed Epithelial-Mesenchymal Interactions to Cancer Pathogenesis. In: Goldhirsch, A. (eds) Endocrine Therapy of Breast Cancer V. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77662-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-77662-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77664-9

  • Online ISBN: 978-3-642-77662-5

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