Abstract
Raf-1 serine/threonine protein kinase is a mitogen-regulated cytosolic enzyme that is essential for growth of NIH/3T3 cells induced by serum, PDGF, PkC or ras (Kolch et al., 1991) as well as myeloid FDC-P1 cells induced by IL-3 or erythropoietin (Carroll et al., 1991). The requirement for growth induction correlates with its requirement for AP-1/Ets dependent transcriptional trans-activation (Bruder et al., 1992) and is consistent with the function of Raf kinase as a shuttle enzyme that connects activation of growth factor receptors at the cell membrane with cell cycle progression-related transcriptional events in the nucleus (Rapp, 1991). Several lines of evidence have demonstrated a role of Raf family protein kinases in growth and differentiation of T -/B-lymphoid and myeloid lineage cells (Table 1)
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Troppmair, J., Cleveland, J.L., Askew, D.S., Rapp, U.R. (1992). v-Raf/v-Myc Synergism in Abrogation of IL-3 Dependence: v-Raf Suppresses Apoptosis. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_57
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