Abstract
Tumor necrosis factor-α (TNF) and interleukin-1 (IL-1) are pluripotent peptide hormones secreted by macrophages in response to endotoxin (LPS) and other stimuli. These cytokines bind to specific receptors on virtually every tissue and affect a vast array of cellular functions many of which provide essential control of homeostasis for the organism as a whole. It is apparent that the genes for these cytokines are highly conserved such that essentially all higher organisms possess these genes as part of an intercellular communication network.
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© 1993 Springer-Verlag Berlin Heidelberg
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Norton, J.A., Alexander, H.R. (1993). Tumor Necrosis Factor-α and Interleukin-1 Desensitization: Clinical Utility and Possible Mechanisms. In: Schlag, G., Redl, H., Traber, D. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77420-1_13
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DOI: https://doi.org/10.1007/978-3-642-77420-1_13
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