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Shock, Sepsis, and Organ Failure pp 307–331Cite as

Tumor Necrosis Factor-α and Interleukin-1 Desensitization: Clinical Utility and Possible Mechanisms

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Abstract

Tumor necrosis factor-α (TNF) and interleukin-1 (IL-1) are pluripotent peptide hormones secreted by macrophages in response to endotoxin (LPS) and other stimuli. These cytokines bind to specific receptors on virtually every tissue and affect a vast array of cellular functions many of which provide essential control of homeostasis for the organism as a whole. It is apparent that the genes for these cytokines are highly conserved such that essentially all higher organisms possess these genes as part of an intercellular communication network.

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Authors and Affiliations

  1. Surgical Metabolism, Surgery Branch, National Cancer Institute, Bethesda, Maryland, 20892, USA

    Jeffrey A. Norton & H. Richard Alexander

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  1. Jeffrey A. Norton
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  2. H. Richard Alexander
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Editors and Affiliations

  1. Ludwig-Boltzmann-Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A - 1200, Vienna, Austria

    Günther Schlag M. D.  & Heinz Redl Ph. D.  & 

  2. Department of Anesthesia, University of Texas, Med. Branch 610 Texas Avenue, Galveston, TX, 77550-1091, USA

    Daniel Traber Ph. D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Norton, J.A., Alexander, H.R. (1993). Tumor Necrosis Factor-α and Interleukin-1 Desensitization: Clinical Utility and Possible Mechanisms. In: Schlag, G., Redl, H., Traber, D. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77420-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-77420-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55339-7

  • Online ISBN: 978-3-642-77420-1

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