Abstract
The Quantitative Structure-Activity Relationship (QSAR) methods are an important tool for the study of biological action mechanisms and for the prediction of chemical activity. The QSAR studies, although originally developed at the end of last century, were spurred on in the Sixties by the contributions of Corwin Hansen, as well as other investigators. It has been found that, for congeneric chemicals, it is possible to quantitatively correlate biological activity with physical chemical properties, such as hydrophobicity, steric and electronic factors (Hansch, 1990). Congeneric chemicals are those agents that share a common skeleton, but have different substituents attached to it. This approach –called extrathermodynamic or the Hansch approach- has been subsequently applied to a large number of situations, and has been highly refined. A great advantage of this method is that the physical chemical properties of most chemicals can be theoretically estimated.
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© 1992 Springer-Verlag Berlin Heidelberg
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Benigni, R., Giuliani, A. (1992). QSAR Studies in Genetic Toxicology: Congeneric and Non Congeneric Chemicals. In: Bolt, H.M., de Wolff, F.A., Henderson, P.T. (eds) Medical Toxicology. Archives of Toxicology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77260-3_30
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DOI: https://doi.org/10.1007/978-3-642-77260-3_30
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