Abstract
The treatment of metastatic cancer remains the preeminent problem in neoplasia. Despite significant advances in our understanding of some of the molecular mechanisms in carcinogenesis and tumor progression, our ability to translate these findings into clinical treatment remains limited. While these molecular studies evolve, the more immediate need for new treatment modalities has led to a more intense evaluation of current approaches to therapy, including surgery, radiation and chemotherapy. In addition, we have also seen a resurgent interest in immunotherapy, which has led to promising approaches in some diseases. Unfortunately, the goal of developing specific systemic immunotherapy remains elusive. In this manuscript we will describe some ideas we have used in our attempt to treat established metastases in murine models.
Supported in part by PHS Grants 38853 and 41525 and The Sid Richardson Foundation
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© 1992 Springer-Verlag Berlin Heidelberg
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Frost, P. (1992). Alien Gene Transfection and the Immune Response to Tumors. In: Staehler, G., Pomer, S. (eds) Basic and Clinical Research on Renal Cell Carcinoma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76863-7_13
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DOI: https://doi.org/10.1007/978-3-642-76863-7_13
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