Abstract
Surface mucus cells (SMCs) of the gastric epithelium are the target cells for H. pylori colonization [1]. In contrast epithelial cells with absorptive function lining the duodenal and intestinal mucosa were never found to be colonized by H. pylori. The specific interrelationship (i.e. adhesion) between H. pylori and its gastric target cell is responsible for the unique location of H. pylori in the stomach (antrum and body area) with the only exception of its ectopic localization on metaplastic gastric SMCs in different parts of the gastrointestinal tract. Outside of the stomach H. pylori has been detected on gastric type epithelium in the duodenum [2–4], in the esophagus [5], Meckel’s diverticula [6] and the rectum [7].
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References
Bode G, Malfertheiner P, Ditschuneit H (1988) Pathogenetic implications of ultrastructural findings in Campylobacter pylori related gastroduodenal disease. Scand J Gastroenterol [Suppl 142] 23:25–39.
Wyatt JI (1989) Relationship of C. pylori to duodenal disease. (in press).
Malfertheiner P, Bode G, Vanek E, Stanescu A, Lutz E, Blessing J, Ditschuneit H (1987) Campylobacter pylori-besteht ein Zusammenhang mit der peptischen Ulcuskrankheit? Dtsch Med Wschr 112:493–497.
Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, Phillips M, Waters TE, Sanderson CR (1988) Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet I:1437–1442.
Hazell SL, Carrick J, Lee A (1988) Campylobacter pylori can infect the esophagus when gastric tissue is present (abstract). Gastroenterology 94:178.
DeCothi GA, Newbold KM, O’Connor HJ (1989) Campylobacter-like organisms and heterotopic gastric mucosa in Meckel’s diverticula. J Clin Pathol 42:132–134.
Pambianco DJ, Dye KR, Marshall BJ et al. (1988) Gastritis in the rectum: campylobacterlike organisms in heterotopic inflamed gastric mucosa. Gastroenterology 94: A340.
Goodwin CS (1988) Duodenal ulcer, Campylobacter pylori, and the “leaking roof” concept. Lancet 1467-1469.
Graham DY (1989) Campylobacter pylori and peptic ulcer disease. Gastroenterology 96:615–625.
Kreuning J, Bosman FT, Kuiper G, Wall AM, Lindeman L (1978) Gastric and duodenal mucosa in “healthy” individuals. J Clin Pathol 31:69–77.
Lawson HH (1988) Definition of gastroduodenal junction in healthy subjects. J Clin Pathol 41:393–396.
Wolff M (1971) Heterotopic gastric epithelium in the rectum. A report of three new cases with a review of 87 cases of gastric heterotopia in the alimentary canal. Am J Clin Pathol 55:604–616.
Willis RA (1968) Some unusual heterotopias. Br Med J 3:267–272.
Lessells AM, Martin DF (1982) Heterotopic gastric mucosa in the duodenum. J Clin Pathol 35:591–595.
Ikeda K, Sannohe Y, Murayama H et al. (1982) Heterotopic gastric mucosa in the duodenum — reaction to congo red under fiberscopic observation. Endoscopy 14:168.
Carrick J, Lee A, Hazell S, Ralston M, Daskalopoulos G (1989) Campylobacter pylori, duodenal ulcer, and gastric metaplasia: possible role of functional heterotopic tissue in ulcerogenesis. Gut 30:790–797.
James AG (1964) Gastric epithelium in the duodenum. Gut 5:285–294.
Wyatt JI, Rathbone BJ, Dixon MF, Heatley RV (1987) Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol 40:841–848.
Shousha S, Parkins RA, Bull TB (1983) Chronic duodenitis with gastric metaplasia: electron microscopic study including comparison with normal. Histopathology 7:873.
Patrick WJA, Denham D, Forrest PM (1974) Mucous changes in the human duodenum: a light and electron microscopic study and correlation with disease and gastric acid secretion. Gut 15:767–776.
Gregory MA, Moshal MG, Spitaels JM (1982) Changes in the morphology of villar epithelial cells adjacent to duodenal ulcers during the process of healing. Scand J Gastroenterol 17:441–448.
Steer HW (1984) Surface morphology of the gastroduodenal mucosa in duodenal ulceration. Gut 25:1203–1210.
Malfertheiner P, Bode G, Mader U, Baczako K, Stanescu A, Ditschuneit H (1985) Histologische und ultrastrukturelle Befunde in der Abheilungsphase des Ulcus duodeni. Klin Wochenschr 63:1061–1070.
Malfertheiner P, Bode G, Stanescu A, Ditschuneit H (1989) Gastric metaplasia and Campylobacter pylori in duodenal ulcer disease: an ultrastructural analysis. Gastroenterol Clin Biol 13:71B–74B.
Antonius JI, Gump FE, Lattes R, Lepore M (1960) A study of certain microscopic features in regional enteritis, and their possible prognostic significance. Gastroenterology 38:889–905.
Nawaz K, Graham DY, Fechner RE, Eiband JM (1974) Gastric heterotopia in the ileum with ulceration and chronic bleeding. Gastroenterology 66:113–117.
Rhodes J (1964) Experimental production of gastric epithelium in the duodenum. Gut 5:454–458.
Gaskin RJ, Gad A, Barros AAJ, Jeffe SN, Baron JM (1975) Natural history and morphology of secretagogue-induced ulcers in rats. Gastroenterology 69:903.
Florey HW, Jennings MA, Jennings DA, O’Connor RC (1939) The reactions of the intestine of the pig to gastric juice. J Pathol Bacteriol 49:105–123.
James AH (1962) Gastric epithelium in the duodenum of a patient with gastric hyperacidity. II World Congress of Gastroenterology, Munich, 11:540–543.
Parrish JA, Rawlings DC (1965) Intestinal mucosa in the Zollinger-Ellison syndrome. Gut 6:286–289.
Wyatt JI, Rathbone BJ (1989) Gastric metaplasia in the duodenum and Campylobacter pylori. Gastroenterol Clin Biol 13:78B–82B.
Malfertheiner P, Bode G, Stanescu A, Ditschuneit H (1989) Gastric metaplasia in the duodenum — a persistent condition following ulcer healing. Gastroduodenal Disease and Campylobacter pylori. Charlottesville, Virginia 21 (Abstract)
Isenberg JI, Selling JA, Hogan DL, Koss MA (1987) Impaired duodenal mucosal bicarbonate secretion in duodenal ulcer patients. N Engl J Med 316:374–379.
Flemström G, Turnberg LA (1984) Gastroduodenal defence mechanisms. Clin Gastroenterol 13:327–354.
Burette A, De Prez C, Glupzynski Y, Nyst JF, Deltenre M (1989) Prevalence of gastric metaplasia and Campylobacter pylori infection in the duodenum and relationship to infection. In: Megraud F, Lamouliatte H (eds) Gastroduodenal pathology and Campylobacter pylori. Elsevier, New York, pp 327–331.
Johnston BJ, Reed PI, Ali MH (1988) Prevalence of Campylobacter pylori in duodenal and gastric mucosa — relationship to inflammation. Scand J Gastroenterol [Suppl 142] 23:69–75.
Bode G, Malfertheiner P, Kullmann C, Ditschuneit H (1989) Gastritis and duodenal ulcer: lectin-binding characteristics of Campylobacter pylori infected and noninfected surface mucous cells. In: Megraud F, Lamouliatte H (eds) Gastroduodenal pathology and Campylobacter pylori. Elsevier, New York, pp 353–359.
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Malfertheiner, P., Stanescu, A., Bode, G., Baczako, K., Kühl, P., Ditschuneit, H. (1990). Gastric Metaplasia in Duodenal Mucosa — Key Factor for H. pylori Colonization and Duodenal Ulcer Pathogenesis?. In: Malfertheiner, P., Ditschuneit, H. (eds) Helicobacter pylori, Gastritis and Peptic Ulcer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75315-2_42
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DOI: https://doi.org/10.1007/978-3-642-75315-2_42
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