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Die Bedeutung der Arachidonsäure-Metaboliten für die Entzündungsreaktion

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Dermatologie und Rheuma

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Zusammenfassung

Die Haut nimmt trotz ihres im Vergleich zu anderen Organen einfachen Aufbaus und einer Dicke von nur wenigen Millimetern eine Vielzahl von Funktionen wahr. Sie bietet Schutz vor mechanischen, chemischen und thermischen Einflüssen und vermittelt als Sinnesorgan zwischen Körper und Umwelt. Erst in jüngster Zeit wurde erkannt, daß die Haut, als großflächiges Kontaktorgan ständig einer direkten Einwirkung von Fremdstoffen ausgesetzt, selbst eine aktive Rolle bei immunologischen Auseinandersetzungen übernimmt (Übersichten bei Patterson & Edelson, 1982; Streilein, 1983):

  • Keratinozyten produzieren hormon-ähnliche Moleküle, die in vielfältiger Weise Einfluß auf die Entwicklung und Funktion von Lymphozyten nehmen,

  • mit der Langerhans-Zelle besitzt die Haut einen eigenen, spezialisierten Zelltyp zur Präsentation von Antigenen,

  • es existieren T-Lymphozyten mit einer ausgeprägten Affinität zur Haut,

  • zwischen Haut und Thymus besteht eine strukturelle Verwandtschaft; beide Organe dienen als Reifungsort für Lymphozyten.

Unterstützt durch die Deutsche Forschungsgemeinschaft (Kö 427/7-3) und zeitweise durch den Deutschen Psoriasis-Bund

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  1. M. Stüning
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  2. M. Raulf
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  3. W. König
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  1. Zentrum der Dermatologie und Venerologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankfurt 70, Deutschland

    Hans Holzmann  & Wolfgang Christian Marsch  & 

  2. Dermatologische Klinik, Universitäts-Klinikum der Ruhr-Universität St. Josef-Hospital, Gudrunstraß56, 4630, Bochum, Deutschland

    Peter Altmeyer

  3. Hoechst AG Pharma Forschung, Postfach 800320, 6230, Frankfurt 80, Deutschland

    H. Gerhard Vogel

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Stüning, M., Raulf, M., König, W. (1987). Die Bedeutung der Arachidonsäure-Metaboliten für die Entzündungsreaktion. In: Holzmann, H., Altmeyer, P., Marsch, W.C., Vogel, H.G. (eds) Dermatologie und Rheuma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72668-2_3

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