Skip to main content
SpringerLink
Log in

Results of Therapy

  • Chapter
Exocrine Pancreatic Cancer

Abstract

Analyzing the results of various methods of treatment is difficult because the patient series providing these results are not homogeneous, and the stage of development of the tumor is not always determined using the same criteria from case to case. Nevertheless, we will try to point out, among the numerous therapeutic options, the advantages of each method as well as the path to be followed. To do this, we must answer three questions: 1. Do pancreatic resections improve the prognosis in comparison with palliative bypasses? 2. Which resections offer the best chance for a cure? 3. Which symptomatic and adjuvant therapies produce the maximum survival (length and comfort)?

This work does not relate our personal experience. Our patient series are limited and do not represent any scientific value and above all any statistical significance (81 surgical cases between 1977 and 1984, including only 15 partial or total resections and 51 by-passes). We deliberately chose to base this work on reviews of recent international studies. The large number of these studies did not allow us to quote them all.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. American Society of Clinical Oncology (1985) Educational symposium and educational workshops. May 19, p 13.

    Google Scholar 

  2. Blievernicht SW, Neifeld JP, Terz JJ, Lawrence W (1980) The role of prophylactic gastro-jejunostomy for unresectable peri-ampullary carcinoma. Surg Gynecol Obstet 151(6): 794–796.

    PubMed  CAS  Google Scholar 

  3. Brooks DL, Osteen RT, Gray EB, et al (1981) Evaluation of palliative procedures for pancreatic cancer. Am J Surg 141: 430–433.

    Article  PubMed  CAS  Google Scholar 

  4. Brooks JR, Culebras JM (1976) Cancer of the pancreas: palliative operation, Whipple procedure or total pancreatectomy? Am J Surg 131: 516–520.

    Article  PubMed  CAS  Google Scholar 

  5. Bukowski RM, Gahbauer R, Rodriguez-Antunez A, Hermann R (1982) Mixed beam radiotherapy and combination chemotherapy in localized pancreatic adenocarcinoma, preliminary results. Int J Radiat Oncol Biol Phys 8(7): 1231–1233.

    PubMed  CAS  Google Scholar 

  6. Burton TY, Kearns TP, Rynearson EH (1957) Diabetic retinopathy following total pancreatectomy. Mayo Clin Proc 32: 735–739.

    CAS  Google Scholar 

  7. Camprodon R, Quintanilla E (1984) Successful long-term results with resection of pancreatic carcinoma in children: favorable prognosis for an uncommon neoplasm. Surgery 95(4): 420–426.

    PubMed  CAS  Google Scholar 

  8. Cancer Facts and Figures (1981) American Cancer Society, New York.

    Google Scholar 

  9. Chigot JP, Riquet M, Ahualli C, Clot JP, Mercadier J (1982) Les résultats des exérèses dans les cancers de la tête du pancreas. J Chir (Paris) 119(6–7): 411–414.

    CAS  Google Scholar 

  10. Crile G (1970) The advantages of bypass operations over radical pancreatoduodenectomy in the treatment of pancreatic carcinoma. Surg Gynecol Obstet 130: 1049–1053.

    PubMed  Google Scholar 

  11. De Battice C, Fetelian D, Deltenre M (1983) Place de la pancréatectomie totale dans le cancer de la tête du pancréas. Acta Chir Belg 83: 89–94.

    PubMed  Google Scholar 

  12. Doutre LP (1980) Exérèse contre dérivation dans les cancers ictérigènes du pancréas. In: Chirurgie abdominale et digestive 2. Masson, Paris, p 56 (Actualités chirurgicales).

    Google Scholar 

  13. Doyle AP, Balcerzak SP, Jeffrey WL (1964) Fatal diabetic glomerulo-sclerosis after total pancreatectomy. N Engl J Med 270: 623–628.

    Article  PubMed  CAS  Google Scholar 

  14. Edis AJ, Kiernan PA, Taylor WF (1980) Attempted curative resection of ductal carcinoma of the pancreas. Mayo Clin Proc 55: 531–536.

    PubMed  CAS  Google Scholar 

  15. Forrest JF, Longmire WP (1979) Carcinoma of the pancreas and peri-ampullary region. A study of 279 patients. Ann Surg 189: 129–138.

    Article  PubMed  CAS  Google Scholar 

  16. Fortner JG (1981) Surgical principles for pancreatic cancer. Regional total or subtotal pancreatectomy. Cancer 47(6): 1712–1718.

    Article  PubMed  CAS  Google Scholar 

  17. Gastro-Intestinal Tumor Study Group (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of bright dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5 fluoro-uracile) and bright dose radiation + 5 fluoro-uracile. Cancer 48(8): 1705–1710.

    Article  Google Scholar 

  18. Goldson AL, Ashaveri E, Espinoza MC, et al (1981) Single hight dose intra-operative electrons for advanced stage pancreatic cancer: phase I pilot study. Int J Radiat Oncol Biol Phys 7: 869–874.

    Article  PubMed  CAS  Google Scholar 

  19. Grosdidier J (1981) Cancer du pancréas. Attitude chirurgicale: exérèse ou dérivation. In: Chirurgie abdominale et digestive 2. Masson, Paris, p 61 (Actualités chirurgicales).

    Google Scholar 

  20. Gunderson LL, Martin JK, Byer DE et al (1984) Intra-operative and external beam irradiation with or without resection: Mayo pilot experience. Mayon Clin Proc 59: 691–699.

    CAS  Google Scholar 

  21. Hermreck AS, Thomas CY, Friesen SR (1974) Importance of pathologic staging in the surgical management of adeno-carcinoma of the exocrine pancreas. Am J Surg 127: 653–657.

    Article  PubMed  CAS  Google Scholar 

  22. Herter FP, Copperman AM, Ahlborn TN, Antinori C (1982) Surgical experience with pancreatic and peri-ampullary cancer. Ann Surg 195: 274–281.

    Article  PubMed  CAS  Google Scholar 

  23. Hicks RE, Brooks JR (1971) Total pancreatectomy for ductal carcinoma. Surg Gynecol Obstet 133: 16–20.

    PubMed  CAS  Google Scholar 

  24. Hodgkinson DJ, Remine WH, Weiland LH (1978) A clinico-pathologic study of 21 cases of pancreatic cystadeno-carcinoma. Ann Surg 188: 679–684.

    Article  PubMed  CAS  Google Scholar 

  25. Hollender LF, Meyer C, Marrie A, Pierard T, Calderoli H (1980) Le cancer du pancréas. Réflexions à propos de 147 cas. Ann Chir 34: 775–777.

    PubMed  CAS  Google Scholar 

  26. Kaiser MH, Ellenberger SS (1985) Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120: 899–903.

    Google Scholar 

  27. Launois B (1984) La Chirurgie du pancreas pour cancer. Bordeaux Med 17: 115–118.

    Google Scholar 

  28. Mongé JJ, Judd ES, Gage RP (1964) Radical pancreatectomy. A 22-year experience with the complications, mortality rate and survival rate. Ann Surg 160(4): 711–719.

    Article  PubMed  Google Scholar 

  29. Moertel CG, Childs DS, Reitemeier RJ, et al (1969) Combined 5-fluoro-uracil and supervoltage radiation therapy of locally unresectable gastro-intestinal cancer. Lancet 2: 865–867.

    Article  PubMed  CAS  Google Scholar 

  30. Moossa AR (1982) Pancreatic cancer. Approach to diagnosis, selection for surgery and choice of operation. Cancer 50 (11): 2689–2698.

    PubMed  CAS  Google Scholar 

  31. Moossa AR, Lewis MH, Mackie CR (1979) Surgical treatment of pancreatic cancer. Mayo Clin Proc 54: 468–474.

    PubMed  CAS  Google Scholar 

  32. Moreaux J, Catala M, Marzano L (1984) Les résultats du traitement chirurgical du cancer du pancreas. Etude d’une série de 96 opérés. Gastroenterol Clin Biol 8: 11–16.

    PubMed  CAS  Google Scholar 

  33. Mouiel J (1983) Dérivation ou exérèse dans le cancer pancréatique? Med Chir Dig 12: 475–478.

    Google Scholar 

  34. Nakase A, Matsumoto Y, Uchida K, Honjo I (1977) Surgical treatment of cancer of the pancreas and the peri-ampullary region: cumulative results in 57 institutions in Japan. Ann Surg 185: 52–57.

    Article  PubMed  CAS  Google Scholar 

  35. Pliam MB, Remine WH (1975) Further evaluation of total pancreatectomy. Arch Surg 110: 506–512.

    PubMed  CAS  Google Scholar 

  36. Sarr MG, Cameron JL (1982) Surgical management of unresectable carcinoma of the pancreas. Surgery 91(2): 123–133.

    PubMed  CAS  Google Scholar 

  37. Shapiro TM (1975) Adenocarcinoma of the pancreas: a statistical analysis of biliary bypass vs Whipple resection in good risk patients. Ann Surg 6: 715–721.

    Article  Google Scholar 

  38. Shipley WU, Wood WC, Tepper JE et al (1984) Intra-operative electron beam irradiation for patients with unresectable pancreatic carcinoma. Ann Surg 200: 289–294.

    Article  PubMed  CAS  Google Scholar 

  39. Solassol C, Joyeux H, Yakoun M, Blanc F, Bories P (1984) La pancréatectomie regionale dans le traitement de l’adénocarcinome du pancréas. A propos de 41 cas. Gastroenterol Clin Biol 8: 17–21.

    PubMed  CAS  Google Scholar 

  40. Van Heerden JA, Remine WH, Weiland LH, et al (1981) Total pancreatectomy for ductal adenocarcinoma of the pancreas. Am J Surg 142: 308–311.

    Article  PubMed  Google Scholar 

  41. Warren KW, Braasch JW, Thum CW (1968) Carcinoma of the pancreas. Surg Clin North Am 48: 601–605.

    PubMed  CAS  Google Scholar 

  42. Warren KW, Braasch JW, Thum CW (1968) Diagnosis and surgical treatment of carcinoma of the pancreas. Curr Probl Surg 70: 3–10.

    Google Scholar 

  43. Wood WC, Shipley WV, Gunderson LL, Cohen AM, Nardi GL (1982) Intra-operative irradiation for unresectable pancreatic carcinoma. Cancer 49(6): 1272–1275

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. Baumel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Deixonne
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chirurgie Digestive, Hôpital Caremeau, Centre hospitalier régional et universitaire de Nîmes, Rue du Prof. Robert-Debré, F-30006, Nîmes, France

    Hughes Baumel  & Bernard Deixonne  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Baumel, H., Deixonne, B. (1986). Results of Therapy. In: Baumel, H., Deixonne, B. (eds) Exocrine Pancreatic Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71178-7_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71178-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71180-0

  • Online ISBN: 978-3-642-71178-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation