Abstract
Based on theoretical considerations, results of animal studies in various autoimmune disease models and anecdotal experience in patients [3], a systematic clinical research programme of ciclosporin (CyA) treatment in various autoimmune diseases was undertaken in 1982. About 1000 patients have since been treated with CyA, and the side-effect profile is emerging.
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References
Adu D, Tumey J, Michael J, et al. (1983) Hyperkalaemia in cyclosporin-treated renal allograft recipients. Lancet II:370
Bennet WM, Pulliam JP (1983) Cyclosporine nephrotoxicity. Ann Intern Med 99:851
Borel JF, von Graffenried B (1984) Sand-immun (cyclosporin A) and autoimmunity. In• Lambert PH, Perrin L, Izui S (eds) Recent Advances in SLE. Academic Press, London, p 313
Chapman JF, Griffiths D, Harding NGL, et al. (1985) Reversibility of cyclosporin nephrotoxicity after three months’ treatment. Lancet I:128
Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creati-nine. Nephron 16:31
Dunn MJ (1984) Nonsteroidal anti-inflammatory drugs and renal function. An-nu Rev Med 35:411
Gutsche HU, Delz E, Luneburg M, et al. (1984) Effect of cyclosporine on the proximal tubular function of the rat kidney. IXth Int. Congress of Nephrology, Los Angeles, June 1984, Abstract, 475A
Kahan BD, van Buren CT, Lin S, et al. (1982) Immunopharmacologic monitoring of cyclosporin A-treated recipients of cadaveric. kidney allografts. Transplantation 34:36
Marbet UA, Graf U, Mihatsch MJ (1980) Renale Nebenwirkungen der Therapie mit Cyclosporin A bei chronischer Polyarthritis und nach Knochenmarkstransplantation. Schweiz Med Wochenschr 110:2017
Mihatsch MJ, Thiel G, Spichtin HP, et al. (1983) Morphological findings in kidney transplants after treatment with cyclospor- ine. Transplant Proc 15:2821
Myers BD, Ross J, Newton L, et al. (1984) Cyclosporine-associated chronic nephropathy N Engl J Med 311:699
Neild GH, Rocchi G, Imbert L, et al. (1984) Effect of cyclosporine on prostacyclin synthesis by vascular tissue in rabbits. In:Kahan BD (ed) Cyclosporine. Grune and Stratton, Orlando, p 182
Palestine AG, Nussenblatt RB, Chan CC (1984) Side effects of systemic cyclosporine in patients not undergoing transplantation Am J Med 77:652
Puttick L, Pollock A, Fairbum E (1983) Treatment of Sézary syndrome with Cyclos-porin A. J Soc Med 76:1063
Stiller CR, Dupré J, Gent M, et al. (1984) Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset.. Science 223:1362
Verani RR, Flechner SM, van Buren CT, et al. (1984) Acute cellular rejection or cyclosporine nephrotoxicity? A review of transplant renal biopsies. Am j Kidney Dis 4:185
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© 1985 Sandoz Ltd, Basle
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von Graffenried, B., Harrison, W.B. (1985). Ciclosporin in Autoimmune Diseases — Side Effects (with Emphasis on Renal Dysfunction) and Recommendations for Use. In: Schindler, R. (eds) Ciclosporin in Autoimmune Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70607-3_9
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DOI: https://doi.org/10.1007/978-3-642-70607-3_9
Publisher Name: Springer, Berlin, Heidelberg
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