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Spasmolytic Action and Clinical Use of Glucagon

  • Chapter
Glucagon II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 66 / 2))

Abstract

The inhibitory effect of glucagon on the motility of the gastrointestinal tract was first described by Stunkard et al. (1955) who noted inhibition of gastric hunger contractions in humans. The mechanism behind this effect could not be determined, but it was noted that it could be “independent of its effect on carbohydrate metabolism” since intravenous glucose injections failed to mimic the effect. Glucagon has since been found to have inhibitory action on the smooth muscle of many organs and species. Wingate and Pearce (1979) have compiled an extensive list of pertinent investigations focusing on the effects of glucagon on gastrointestinal motility, secretion, and absorption, and on blood flow (Table 1). Table 2 lists investigations in other areas in which glucagon has been found to have a similar smooth muscle relaxing effect.

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Authors
  1. B. Diamant
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  2. J. Picazo
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  1. University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  2. University of Brussels (V.U.B.), Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  3. Royal Academy of Medicine of Belgium, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  4. Medical Policlinics, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  5. Division of Diabetes, University of Liège, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

  6. Institut de Médecine, Hôpital de Bavière, Boulevard de la Constitution, 66, 4020, Liège, Belgium

    Pierre J. Lefebvre M.D. (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head) (Professor of Medicine, Guest Professor, Corresponding Member, Chairman, Head)

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Diamant, B., Picazo, J. (1983). Spasmolytic Action and Clinical Use of Glucagon. In: Lefebvre, P.J. (eds) Glucagon II. Handbook of Experimental Pharmacology, vol 66 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69019-8_32

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