Abstract
Axonal regeneration following axotomy may be accelerated in neurons which have undergone a previous axonal injury. When axonal regeneration following an axotomy (the testing lesion) is altered as a result of the axon having undergone a previous injury (the conditioning lesion), we refer to this change as a conditioning lesion effect. The effect of a conditioning lesion is usually (but not always) an acceleration or enhancement of axonal outgrowth. It represents an interesting experimental manipulation which may shed light on the factors which initiate and control axonal regeneration. In this paper, we shall review current knowledge about conditioning lesion effects, present some new data, and discuss possible mechanisms and practical applications of conditioning lesion effects.
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© 1981 Springer-Verlag Berlin Heidelberg
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Forman, D.S., McQuarrie, I.G., Grafstein, B., Edwards, D.L. (1981). Effect of a Conditioning Lesion on Axonal Regeneration and Recovery of Function. In: Flohr, H., Precht, W. (eds) Lesion-Induced Neuronal Plasticity in Sensorimotor Systems. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68074-8_9
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DOI: https://doi.org/10.1007/978-3-642-68074-8_9
Publisher Name: Springer, Berlin, Heidelberg
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