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Immunity and Repression in Bacteriophages P1 and P7

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 90))

Abstract

The temperate phage P1 (Bertani 1951) is a large complex phage whose double stranded DNA has a molecular weight of 66 × 106 (Yun and Vapnek 1977). The DNA in the phage particles is terminally redundant and cyclically permuted (Ikeda and Tomizawa 1968). P1 is best known for its ability to perform generalized transduction (Lennox 1955; Ikeda and Tomizawa 1965) and has been used extensively as a tool in Escherichia coli genetics. Because of its broad host range, P1 also serves as a transducing phage for other bacterial species (Goldberg et al. 1974; Kaiser and Dworkin 1975). Phage P1 is the prototype of a class of temperate phages whose prophage is not integrated into the host chromosome (Ikeda and Tomizawa 1968), and thus the strategies it uses to maintain lysogeny may differ from those used by integrative prophages. The P1 prophage is a plasmid (of molecular weight 61 × 106: Yun and Vapnek 1977) and is maintained at about one copy per cell nucleoid (Ikeda and Tomizawa 1968). So, in addition to regulation of transcription, the P1 prophage must also regulate its replication. P1 has all of the characteristics of both a temperate phage and a plasmid. Like other temperate phages, P1 prophage is repressed for production of lytic phage functions and a P1 lysogen exhibits immunity to superinfection by other P1 phage. Like other plasmids, the P1 prophage exhibits incompatibility with related plasmids, i. e., it cannot coexist in the same cell with another member of the same incompatibility group (Hedges et al. 1975). The mechanism for this phenomenon is not yet understood.

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Authors and Affiliations

  1. Dept. of Microbiology, Emory University School of Medicine, 30322, Atlanta, Georgia, USA

    June Rothman Scott

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  1. June Rothman Scott
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Editor information

Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & F. Melchers  & 

  2. Seattle, USA

    S. Falkow

  3. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  4. Martinsried, Germany

    P. H. Hofschneider

  5. London, UK

    J. H. Humphrey

  6. Tübingen, Germany

    J. Klein

  7. Düsseldorf, Germany

    P. Koldovský

  8. Copenhagen, Denmark

    O. Maaløe

  9. Gießen, Germany

    R. Rott

  10. Ladenburg/Heidelberg, Germany

    H. G. Schweiger

  11. Prague, Czech Republic

    L. Syruček

  12. Los Angeles, USA

    P. K. Vogt

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© 1980 Springer-Verlag Berlin Heidelberg

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Scott, J.R. (1980). Immunity and Repression in Bacteriophages P1 and P7. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67717-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-67717-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67719-9

  • Online ISBN: 978-3-642-67717-5

  • eBook Packages: Springer Book Archive

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