Abstract
Advances in somatic cell hybridization techniques have made it possible to generate hybrid cell lines producing monospecific antibodies directed at desired antigenic determinants (1). In this paper a modification of the cell fusion procedure (2,3) was used to recover stable hybrid cell lines secreting IgG antibodies to: (a) mouse major histocompatibility complex (MHC) alloantigens (H-2K and I-A); and (b) mouse immunoglobulin (Ig) allotypes (Ig-1b, Ig-5a, and Ig-5b).
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Oi, V.T., Jones, P.P., Goding, J.W., Herzenberg, L.A., Herzenberg, L.A. (1979). Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens. In: Melchers, F., Potter, M., Warner, N.L. (eds) Lymphocyte Hybridomas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67448-8_18
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DOI: https://doi.org/10.1007/978-3-642-67448-8_18
Publisher Name: Springer, Berlin, Heidelberg
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