Skip to main content
SpringerLink
Log in

Transkription der DNS von Viren und Prokaryonten

  • Chapter
Molekular- und Zellbiologie

  • 249 Accesses

Zusammenfassung

Die genetische Information eines Organismus ist in der DNS linear niedergelegt. Um sie zu nutzen, muß sie zunächst komplett oder in Teilen abgerufen und von der DNS in RNS überschrieben werden. Diesen Prozeß bezeichnen wir als Transkription. Er wird durch ein Enzym, eine DNS-abhängige RNS-Polymerase, katalysiert. Der Transkriptionsprozeß ist einer der entscheidenden Kontrollmechanismen der Genexpression. Er unterliegt Regulations- und Modulationsvorgängen und besteht aus einer Anzahl hochspezifischer Teilschritte. Man unterscheidet dabei einmal zwischen dem enzymatischen Prozeß, durch den eine bestimmte Nukleotidsequenz von einem Makromolekül (DNS-Matrize) auf ein anderes (RNS: Matrize der Proteinbiosynthese) übertragen wird und den Erkennungsvorgängen, die dafür sorgen, daß die Transkriptionsmaschinerie die spezifischen Start- und Stopsignale auf der DNS-Matrize findet. Hierdurch wird eine Selektivität der Transkription gewährleistet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Beckwith, J., Zipser, D. (eds.): The lactose Operon. New York: Cold Spring Harbor Labortory 1970

    Google Scholar 

  • Bennett, G.N., Schweinegruber, M.E., Brown, K.D., Squires, C., Yanofsky, C.: Nucleotide sequence of region preceding trp mRNA initiation site and its role in promotor and operator function. Proc. Natl. Acad. Sci. USA 73, 2351 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Berk, A.J., Sharp, P.A.: Spliced early mRNAs of simian virus 40. Proc. Natl. Acad. Sci. USA 75, 1274 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Bertrand, K., Korn, L., Lee, F., Hatt, T., Squires, C.L., Squires, C., Yanofsky, C.: New features of the regulation of the tryptophan operon. Science 189, 22 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Bremer, H.: Chain growth rate and length of enzymatically synthesized RNA molecules. Mol. Gen. Genet. 99, 362 (1967)

    PubMed  CAS  Google Scholar 

  • Chamberlin, M.J.: The selectivity of transcription. Annu. Rev. Biochem. 43, 721 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Chow, L.T., Gelinas, R.E., Broker, T.R., Roberts, R.: An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA. Cell 12, 1 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Delius, H., Westphal, H., Axelrod, N.: Length measurements of RNA synthesized in vitro by Escherichia coli RNA polymerase. J. Mol. Biol. 74, 677 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Dickson, R.C., Abelson, J., Barnes, W.M., Reznikoff, W.S.: Genetic regulation: The lac control region. Science 187, 27 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Dickson, R.C., Abelson, J., Johnson, P.: Nucleotide sequence changes produced by mutations in the lac promoter of Escherichia coli. J. Mol. Biol. 111, 65 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Farabaugh, P.J.: Sequence of the lacI gene. Nature (London) 274, 765 (1978)

    Article  CAS  Google Scholar 

  • Flint, J.: The topography and transcription of the adenovirus genome. Cell 10, 153 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Frederick, R.J., Snyder, L.: Regulation of anti-late RNA synthesis in bacteriophage T4: A delayed early control. J. Mol. Biol. 114, 461 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Gabain, A.v., Bujard, H.: Interaction of E. coli RNA polymerase with promoters of coliphage T5. Mol. Gen. Genet. 157, 301 (1977)

    Article  Google Scholar 

  • Gabain, A.v., Hayward, G.S., Bujard, H.: Physical mapping of the Hind III, EcoR I, Sal and Sma restriction endonuclease cleavage fragments from bacteriophage T5 DNA. Mol. Gen. Genet. 143, 279 (1976)

    Article  Google Scholar 

  • Ghosh, P.K., Reddy, B., Swinscoe, J., Choudary, P.V., Lebowitz, P., Weissman, S.M.: The 5′-terminal leader sequence of late 16S mRNA from cells infected with simian virus 40. J. Biol. Chem. 253, 3643 (1978)

    PubMed  CAS  Google Scholar 

  • Gilbert, W.: Starting and stopping sequences for RNA-polymerase. In: RNA polymerase. Losick, R., Chamberlin, M. (eds.). New York: Cold Spring Harbor Laboratory 1976

    Google Scholar 

  • Gilbert, W., Maizels, N., Maxam, A.: Sequences of controlling regions of the lactose operon. Cold Spring Harbor Symp. Quant. Biol. 38, 845 (1974)

    PubMed  CAS  Google Scholar 

  • Greenblatt, J., Schleif, R.: Arabinose C protein: regulation of the arabinose operon in vitro. Nature New Biol. 223, 166 (1971)

    Google Scholar 

  • Hahn, W.E., Pettijohn, D.E., Ness J. van: One strand equivalent of the Escherichia coli genome is transcribed: complexity and abundance classes of mRNA. Science 197, 582 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Hayward, S.D., Smith, M.G.: The chromosome of bacteriophage T5. J. Mol. Biol. 80, 345 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Johnson, A., Meyer, B.J., Ptashne, M.: Mechanism of action of the cro protein of bacteriophage X. Proc. Natl. Acad. Sci. USA 75, 1783 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Jovin, T.M.: Recognition mechanisms of DNA-specific enzymes. Annu. Rev. Biochem. 45, 889 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Kitchingman, G.R., Lai, S.P., Westphal, H.: Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA. Proc. Natl. Acad. Sci. USA 74, 4392 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Klessig, D.F.: Two adenovirus mRNAs have a common 5′ terminal leader sequence encoded at least 10 kb upstream from their main coding regions. Cell 12, 9 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Lee, F., Bertrand, K., Bennett, G., Yanofsky, C.: Comparison of the nucleotide sequences of the initial transcribed regions of the tryptophan operons of Escherichia coli and Salmonella typhimurium. J. Mol. Biol. 121, 193 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Losick, R., Chamberlin, M. (eds.): RNA polymerase. New York: Cold Spring Harbor Laboratory 1976

    Google Scholar 

  • Maniatis, T., Ptashne, M., Backman, K., Kleit, D., Flashman, S., Jeffrey, A., Maurer, R.: Sequences of repressor binding sites in the operators of bacteriophage X. Cell 5, 109 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Maurer, R., Maniatis, T., Ptashne, M.: Promoters are in the operators in phage lambda. Nature (London) 249, 221 (1974)

    Article  CAS  Google Scholar 

  • Meyer, B.J., Kleid, D.G., Ptashne, M.: X repressor turns off transcription of its own gene. Proc. Natl. Acad. Sci. USA 72, 4785 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Philipson, L.: Adenovirus gene expression — a model for mammalian cells. FEBS Lett. 74, 167 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Pirotta, V.: Sequence of OR operator of phage λ. Nature (London) 254, 114 (1975)

    Article  Google Scholar 

  • Pribnow, D.: Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter. Proc. Natl. Acad. Sci. USA 72, 784 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Ptashne, M., Backman, K. Humayun, M.Z., Jeffrey, A., Maurer, R., Meyer, B., Sauer, R.T.: Autoregulation and function of a repressor in bacteriophage lambda. Science 194, 156 (1976)

    Article  PubMed  CAS  Google Scholar 

  • Sauer, R.T., Anderegg, R.: Primary structure of the X repressor. Biochemistry 17, 1092 (1978)

    Article  PubMed  CAS  Google Scholar 

  • Schaller, H., Gray, C., Herrmann, K.: Nucleotide sequence of an RNA polymerase binding site from the DNA of bacteriophage fd. Proc. Natl. Acad. Sci. USA 72, 737 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Seeburg, P., Schaller, H.: Mapping and characterization of promoters in bacteriophages fd, fl and M13. J. Mol. Biol. 92, 261 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Seeburg, P.H., Nüsslein, C., Schaller, H.: Interaction of RNA polymerase with promoters from bacteriophage fd. Eur. J. Biochem. 74, 107 (1977)

    Article  PubMed  CAS  Google Scholar 

  • Smith, G.R., Magasanik, B.: Nature and selfregulated synthesis of the repressor of the hut operons in Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 68, 1493 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Stiiber, D., Delius, H., Bujard, H.: Electron microscopic analysis of in vitro transcriptional complexes: mapping of promoters of the coliphage T5 genome. Mol. Gen. Genet. 166, 141 (1978)

    Article  Google Scholar 

  • Szybalski, W.: Genetic and molecular map of Escherichia coli bacteriophage lambda (λ). In: Handbook of chemistry and molecular biology. Fasman, G.D. (ed.). Cleveland, Ohio: C.R.C. Press. Nucleic Acids 2, 677 (1976)

    Google Scholar 

  • Szybalski, W.: Initiation and regulation of transcription and DNA replication in coliphage lambda. In: Regulatory biology. Copeland, J.C., Marzluff, G.A. (eds.), S. 3–45. Columbus, Ohio: Ohio State University Press 1977

    Google Scholar 

  • Talkinton, S., Pero, I.: Restriction fragment analysis of the temporal program of bacteriophage SPO1 transcription and its control by phage-modified RNA polymerase. Virology 83, 365 (1977)

    Article  Google Scholar 

  • Walz, A., Pirotta, V., Ineichen, K.: X repressor regu-lates the switch between PR and Prm promoters. Nature (London) 262, 665 (1976)

    Article  CAS  Google Scholar 

  • Westphal, H., Lai, S.P.: Quantitative electron microscopy of early adenovirus RNA. J. Mol. Biol. 116, 525 (1977)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fakultät für Biologie, Universität Bielefeld, D-4800, Bielefeld 1, Deutschland

    Professor Dr. Peter von Sengbusch

Authors
  1. Professor Dr. Peter von Sengbusch
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

von Sengbusch, P. (1979). Transkription der DNS von Viren und Prokaryonten. In: Molekular- und Zellbiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67358-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67358-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67359-7

  • Online ISBN: 978-3-642-67358-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation