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Nucleotide Pool Imbalance

  • Chapter
Drug Toxicity in Embryonic Development I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 124 / 1))

Abstract

Ribonucleotides (NTP) and deoxyribonucleotides (dNTP) are the basic building blocks of RNA and DNA. While the major nucleotides are found in all mammalian cells their relative pool sizes are quite different depending on the cell type and species. These unique nucleotide pool patterns are maintained to a large extent, by the tightly regulated biosynthetic and metabolic pathways through a number of feedback controls. Disruption of these balances have been shown to have profound effects on DNA synthesis and replication in cultured cells (Ashman and Davidson 1981; Topal and Baker 1982; Das et al. 1983; Newman and Miller 1983; Meuth 1984; Nicander and Reichard 1985; Yosmoka et al. 1987; Phear and Meuth 1989; Kohalmi et al. 1991; Wataya et al. 1993). In fact, this biological feature has become a fundamental tenet for the design of chemotherapeutic agents in the past half century.

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  1. Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA

    Robert J. Kavlock Ph.D. (Director) (Director)

  2. Miami Valley Laboratories, The Procter and Gamble Company, P.O. Box 538707, 45253, Cincinnati, OH, USA

    George P. Daston Ph.D.

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Lau, C. (1997). Nucleotide Pool Imbalance. In: Kavlock, R.J., Daston, G.P. (eds) Drug Toxicity in Embryonic Development I. Handbook of Experimental Pharmacology, vol 124 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60445-4_13

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