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Vanadium-Containing Insulin Biomimetic Drugs

  • Chapter
Metallopharmaceuticals II

Part of the book series: Topics in Biological Inorganic Chemistry ((TBIC,volume 2))

Abstract

Vanadium-containing metallocomplexes are being widely investigated as potential insulin-enhancing or replacement pharmaceutical agents. Experimental evidence of inorganic vanadium’s insulin-mimetic effects, with the immensely appealing feature of oral bioavailability, has prompted design and development of novel organic ligands. Desirable features include low molecular weight, neutral charge, thermodynamic and hydrolytic stability, and a balance between aqueous solubility and lipophilicity. From the initial development of bis(maltolato)oxovanadium(IV), containing the ligand, maltol, which is an approved food additive, to more recent development of metallocomplexes such as imidazoleoxobisperoxovanadate(V), which seek to mimic the active site of vanado-enzymes, such as bromperoxidase, researchers have examined a variety of compounds as solutions to the problems of improved absorption, coupled with minimal toxicity. Also detailed are 5-, 6-, and 7-coordinated compounds, with V-N, V-O, V-S, and temporary complexation, as well as the peroxovanadates currently in development as insulin-mimetic agents.

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Authors and Affiliations

  1. Medicinal Inorganic Chemistry Group, Department of Chemistry and Faculty of Pharmaceutical Sciences, University of British Columbia, B.C., V6T 1Z1, Canada

    K. H. Thompson, J. H. McNeill & C. Orvig

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  1. K. H. Thompson
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  2. J. H. McNeill
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  3. C. Orvig
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Editors and Affiliations

  1. Department of Chemistry, Boston College, Merkert Center, 02467, Chestnut Hill, MA, USA

    Michael J. Clarke

  2. Department of Chemistry, University of Edinburgh, King’s Buildings West Mains Road, EH9 3JJ, Edinburgh, Scotland, GB

    Peter J. Sadler

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Thompson, K.H., McNeill, J.H., Orvig, C. (1999). Vanadium-Containing Insulin Biomimetic Drugs. In: Clarke, M.J., Sadler, P.J. (eds) Metallopharmaceuticals II. Topics in Biological Inorganic Chemistry, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60061-6_4

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