Skip to main content
Book cover

Cosmetics pp 156–166Cite as

Efficacy of Barrier Creams (Skin Protective Creams)

  • Chapter

Abstract

The concept of barrier creams (BC) has been around since the early 20th century. In practice, their utilization remains the subject of a lively debate; some suggest that inappropriate BC application may induce additional irritation rather than benefit [1-5]. To evaluate BC efficacy, in vivo and in vitro methods have been developed. In particular, recent bioengineering techniques provide more accurate quantitative data than supplied by traditional clinical studies dependent on visual scoring.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lachapelle JM (1996) Efficacy of protective creams and/or gels, in prevention of contact dermatitis. In: Eisner P, Lachapelle JM, Wahlberg JM, Maibach HI (eds) Prevention of contact dermatitis. Curr Probl Dermatol. Karger, Basel, p 182

    Google Scholar 

  2. Frosch PJ, Schulze-Dirks, A,Hoffmann, M,Axthelm, I,KurteA (1993) Efficacy of skin barrier creams. I. The repetitive irritation test (RIT) in the guinea pig. Contact Dermatitis 28:94

    CAS  Google Scholar 

  3. Frosch PJ, Schulze-Dirks A, Hoffmann M, Axthelm I (1993) Efficacy of skin barrier creams. II. Ineffectiveness of a popular “skin protector” against various irritants in the repetitive irritation test in the guinea pig. Contact Dermatitis 29:74

    Article  PubMed  CAS  Google Scholar 

  4. Frosch PJ, Kurte A, Pilz B (1993) Biophysical techniques for the evaluation of skin protective creams. In: Frosch PJ, Kligman AM (eds) Noninvasive methods for the quantification of skin functions. Springer-Verlag, Berlin Heidelberg New York, pp 214

    Google Scholar 

  5. Zhai H, Maibach HI (1996) Effect of barrier creams: human skin in vivo. Contact Dermatitis 35:92

    Article  PubMed  CAS  Google Scholar 

  6. Zhai H, Maibach HI (1996) Percutaneous penetration (dermatopharmacokinetics) in evaluating barrier creams. In: Eisner P, Lachapelle JM, Wahlberg JM, Maibach HI (eds) Prevention of contact dermatitis. Curr Probl Dermatol. Karger, Basel, p 193

    Google Scholar 

  7. Loden M (1986) The effect of 4 barrier creams on the absorption of water, benzene, and formaldehyde into excised human skin. Contact Dermatitis 14:292

    Article  PubMed  CAS  Google Scholar 

  8. Guillemin M, Murset JC, Lob M, Riquez J (1974) Simple method to determine the efficiency of a cream used for skin protection against solvents. Br J Ind Med 31:310

    PubMed  CAS  Google Scholar 

  9. Goh CL (1991) Cutting oil dermatitis on guinea pig skin. II. Emollient creams and cutting oil dermatitis. Contact Dermatitis 24:81

    CAS  Google Scholar 

  10. Schwartz L, Warren LH, Goldman FH (1940) Protective ointment for the prevention of poison ivy dermatitis. Public Health Rep 55:1327

    Google Scholar 

  11. Sadler CGA, Marriott RH (1946) The evaluation of barrier creams. Br Med J 23:769

    Article  Google Scholar 

  12. Wahlberg JE (1971) Absorption-inhibiting effect of barrier creams. Dermatosen 19:197

    CAS  Google Scholar 

  13. Wahlberg JE (1972) Anti-chromium barrier cream. Dermatologica 145:175

    Article  PubMed  CAS  Google Scholar 

  14. Langford NP (1978) Fluorochemical resin complexes for use in solvent repellent hand creams. Am Ind Hyg Assoc J 39:33

    PubMed  CAS  Google Scholar 

  15. Reiner R, Rofimann K, Hooidonk CV, Ceulen BI, Bock J (1982) Ointments for the protection against organophosphate poisoning. Arzneimed Forsch/Drug Res 32:630

    CAS  Google Scholar 

  16. Mahmoud G, Lachapelle JM, Neste DV (1984) Histological assessment of skin damage by irritants: its possible use in the evaluation of a “barrier cream”. Contact Dermatitis 11:179

    Article  PubMed  CAS  Google Scholar 

  17. Mahmoud G, Lachapelle JM (1985) Evaluation of the protective value of an antisolvent gel by laser Doppler flowmetry and histology. Contact Dermatitis 13:14

    Article  PubMed  CAS  Google Scholar 

  18. Mahmoud G, Lachapelle JM (1987) Uses of a guinea pig model to evaluate the protective value of barrier creams and/or gels. In: Maibach HI, Lowe NJ (eds) Models in dermatology. Karger, Basel, p 112

    Google Scholar 

  19. Lachapelle JM, Nouaigui H, Marot L (1990) Experimental study of the effects of a new protective cream against skin irritation provoked by the organic solvents n-hexane, trichlorethylene and toluene. Dermatosen 38:19

    CAS  Google Scholar 

  20. Frosch PJ, Kurte A, Pilz B (1993) Efficacy of skin barrier creams. III. The repetitive irritation test (RIT) in humans. Contact Dermatitis 29:113

    CAS  Google Scholar 

  21. Frosch PJ, Kurte A (1994) Efficacy of skin barrier creams. IV. The repetitive irritation test (RIT) with a set of 4 standard irritants. Contact Dermatitis 31:161

    Article  PubMed  CAS  Google Scholar 

  22. Treffel P, Gabard B, Juch R (1994) Evaluation of barrier creams: an in vitro technique on human skin. Acta Dermatol Venereol 74:7

    CAS  Google Scholar 

  23. Fullerton A, Menne T (1995) In vitro and in vivo evaluation of the effect of barrier gels in nickel contact allergy. Contact Dermatitis 32:100

    Article  PubMed  CAS  Google Scholar 

  24. Zhai H, Willard P, Maibach HI (1998) Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human model. Contact Dermatitis 38:155

    CAS  Google Scholar 

  25. Zhai H, Buddrus DJ, Schulz AA, Wester RC, Hartway T, Serranzana S, Maibach HI (1998) In vitro percutaneous absorption of sodium lauryl sulfate (SLS) in human skin decreased by Quaternium-18 bentonite gels. Presented at the American Academy of Dermatology 56th Annual Meeting, Orlando, February 27, pp 113

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Zhai, H., Maibach, H.I. (1999). Efficacy of Barrier Creams (Skin Protective Creams). In: Elsner, P., Maibach, H.I., Merk, H.F. (eds) Cosmetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59869-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59869-2_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64160-2

  • Online ISBN: 978-3-642-59869-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics