Abstract
The name protein is derived from the greek word “proteno” — the first. Actually, the philosopher Engels defined life as the living form of protein. Proteins are associated with all forms of life, an observation that dates back to the original identification of proteins as a class by Mulder in 1838. Their importance lies in the fact that proteins are the principal nitrogenous constituents of every cell in the body (half of the dry weight, 90% as enzymes). These proteins are subject to continuous wear and replacement.
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References
Laidlaw SA and Kopple JD (1987) Newer concepts of the indispensable amino acids. Am J Clin Nutr 46:593–605
Grimble GK (1994) The significance of peptides in clinical nutrition. Annu Rev Nutr 14: 419–447
Fürst P (1998) Old and new substrates in clinical nutrition. J Nutr 128:789–796
Fürst P (1972) 15N-studies in severe renal failure. II. Evidence for the essentiality of histidine. Scand J Clin Lab Invest 30:307–312
Bergström J, Alvestrand A and Fürst P (1990) Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition. Kidney Int 38:108–114
Najarian N and Harper AE (1956) A clinical study of the effect of arginine on blood ammonia. Am J Med 21:832–842
Kirk SJ and Barbul A (1990) Role of arginine in trauma, sepsis, and immunity. JPEN 14:226S–229S
Evoy D, Lieberman MD, Fahey III TJ and Daly JM (1998) Immunonutrition: The role of Arginine. Nutrition 14:611–617
Barbul A (1990) Arginine and immune function. Nutrition 6:53–58
Daly JM, Reynolds J, Sigal RK, Shou J and Liberman MD (1990) Effect of dietary protein and amino acids on immune function. Crit Care Med 18:S86–S93
Grossie VBJ (1996) Citrulline and arginine increase the growth of the Ward colon tumor in parenterally fed rats. Nutr Cancer 26:91–97
Sodeyama M, Gardiner KR, Regan MC, Kirk SJ, Efron G and Barbul A (1993) Sepsis impairs gut amino acid absorption. Am J Surg 165:150–154
Brittenden J, Park KG, Heys SD, Ross C, Ashby J, Ah-See A and Eremin 0 (1994) L-arginine stimulates host defenses in patients with breast cancer. Surgery 115:205–212
Beaumier L, Castillo L, Ajami AM and Young VR (1995) Urea cycle intermediate kinetics and nitrate excretion at normal and “therapeutic” intakes of arginine in humans. Am J Physiol 269:E884–E896
Lin E, Goncalves JA and Lowry SF (1998) Efficacy of nutritional pharmacology in surgical patients. Curr Opin Clin Nutr Met Care 1:41–50
Nathan C and Xie Q (1994) Nitric oxide synthases: rolls, tolls and controls. Cell 78:915–918
Quyyumi AA (1998) Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and Larginine. J Am Coll Cardiol 32:904–911
Gaull G, Sturman JA and Räihä NCR (1972) Development of mammalian sulfur metabolism: absence of cystathionase in human fetal tissues. Pediat Res 6:538–547
Zlotkin SH, Bryan MH and Anderson GH (1981) Cystine supplementation to cystine-free intravenous feeding regimens in newborn infants. Am J Clin Nutr 34:914–923
Rudman D, Kutner M, Ansley J, Jansen R, Chipponi JX and Bain RP (1981) Hypotyrosinemia, hypocystinemia and failure to retain nitrogen during total parenteral nutrition of cirrhotic patients. Gastroenterol 81:1025–1035
Chawla RK, Lewis FW, Kutner M, Bate DM, Roy RGB and Rudman D (1984) Plasma cysteine, cystine, and glutathione in cirrhosis. Gastroenterol 87:770–776
Stegink LD and Den Besten L (1972) Synthesis of cysteine from methionine in normal adult subjects: effect of route of alimentation. Science 178:514–516
Grimble RF and Grimble GK (1998) Immunonutrition: Role of sulfur amino acids, related amino acids, and polyamines. Nutrition 14:605–610
Grimble RF (1994) Nutritional antioxidants and the modulation of inflammation: theory and practice. New Horiz 2:175–185
Ollenschläger G, Jansen S, Schindler J, Rasokat H, Schrappe-Bächer M and Roth E (1988) Plasma amino acid pattern of patients with HIV infection. Clin Chem 34:1787–1789
Dröge W (1993) Cysteine and glutathione deficiency in AIDS patients: A rationale for the treatment with N-acetyl-cysteine. Pharmacology 46:61–65
Mihm S, Ennen J and Pessagra U (1991) Inhibition of HIV-1 replication and NFKB activity by cysteine and cysteine derivatives. AIDS 5:497–503
Fürst P (1994) New parenteral substrates in clinical nutrition. Part I. Introduction. New substrates in protein nutrition. Eur J Clin Nutr 48:607–616
Bergström J, Fürst P, Noree L-0 and Vinnars E (1974) Intracellular free amino acid concentration in human muscle tissue. J Appl Physiol 36:693–697
Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163
Redmond HP, Stapleton PP, Neary P and Bouchier-Hayes D (1998) Immunonutrition: the role of taurine. Nutrition 14:599–604
Wang JH, Redmond HP, Watson RWG, Condron C and Bouchier-Hayes D (1995) Taurine protects against stress gene induced human endothelial cell apoptosis. Br J Surg 82:
Neary P, Condron C, Kilbaugh T, Redmond HP and Bouchier-Hayes D (1997) Taurine inhibits fas mediated neutrophil apoptosis. Shock 7:S120
Askanazi J, Carpentier YA, Michelsen CB, Elwyn DH, Fürst P, Kantrowitz LR, Gump FE and Kinney JM (1980) Muscle and plasma amino acids following injury. Influence of intercurrent infection. Ann Surg 192:78–85
Pathirana C and Grimble RF (1992) Taurine and serine supplementation modulates the metabolic response to tumor necrosis factor a in rats fed a low protein diet. J Nutr 122:1369–1375
Geggel HS, Ament ME, Heckenlively JR, Martin DA, Kopple BS and Kopple JD (1985) Nutritional requirement for taurine in patients receiving long-term parenteral nutrition. N Engl J Med 312:142–146
Heird WC, Hay W, Helms RA, Storm MC, Kashyap S and Dell RB (1988) Pediatric parenteral amino acid mixture in low birth weight infants. Pediatrics 81:41–50
Kopple JD, Vinton NE, Laidlaw SA and Ament ME (1990) Effect of intravenous taurine supplementation on plasma, blood cell, and urine taurine concentrations in adults undergoing long-term parenteral nutrition. Am J Clin Nutr 52:846–853
Desai TK, Maliakkal J, Kinzie JL, Ehrinpreis MN, Luk GD and Ceijka J (1992) Taurine deficiency after intensive chemotherapy and/or radiation. Am J Clin Nutr 55:708–711
Bergström J, Alvestrand A, Fürst P and Lindholm B (1989) Sulphur amino acids in plasma and muscle in patients with chronic renal failure: evidence for taurine depletion. J Int Med 226:189–194
Suliman ME, Anderstam B and Bergström J (1996) Evidence of taurine depletion and accumulation of cysteinesulfinic acid in chronic dialysis patients. Kidney Int 50:1713–1717
Banks MA, Porter DW, Martin WG and Castranova V (1992) Taurine protects against oxidant injury to rat alveolar pneumocytes. Adv Exp Med Biol 315:341–354
Gordon RE, Heller RF and Heller RF (1992) Taurine protection of lungs in hamster models of oxidant injury: A morphologic time study of paraquat and bleomycin treatment. Adv Exp Med Biol 315:319–328
Räihä NCR (1973) Phenylalanine hydroxylase in human liver during development. Pediat Res 7:1–4
Alvestrand A, Fürst P and Bergström J (1982) Plasma and muscle free amino acids in uremia: influence of nutrition with amino acids. Clin Nephrol 18:297–305
Fürst P (1983) Intracellular muscle free amino acids - their measurement and function. Proc Nutr Soc 42:451–462
Fürst P, Pogan K and Stehle P (1997) Glutamine dipeptides in clinical nutrition. Nutrition 13:731–737
Souba WW (1991) Glutamine: a key substrate for the splanchnic bed. Annu Rev Nutr 11:285–308
Rennie MJ, MacLennan P, Hundal HS, Weryk B, Smith K, Taylor PM, Egan C and Watt PW (1989) Skeletal muscle glutamine transport, intramuscular glutamine concentration, and muscle-protein turnover. Metabolism 38 (suppl 1):47–51
Plumley DA, Souba WW and Hautamaki RD (1990) Accelerated lung amino acid release in hyperdynamic septic surgical patients. Arch Surg 125:57–61
Rennie MJ, Hundal HS, Babji P, MacLennan P, Taylor PM, Watt PW, Jepson MM and Millward DJ (1986) Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease. Lancet ii:1008–1011
MacLennan P, Smith K, Weryk B, Watt PW and Rennie MJ (1988) Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle. FEBS Lett 237:133–136
Cuthbertson DP (1931) The distribution of nitrogen and sulphur in the urine during conditions of increased catabolism. Biochem J 25:236–244
Cuthbertson DP (1932) Observations on the disturbances of metabolism produced by injury to the limbs. Q J Med 1:223–230
Duke JH, Jorgensen SB, Broell JR, Long CL and Kinney JM (1970) Contribution of protein to caloric expenditure following injury. Surgery 68:168–174
Moore FD and Brennan MR (1975) Intravenous amino acids. N Engl J Med 293:194–195
Shenkin A, Neuhäuser M, Bergström J, Chao L, Vinnars E, Larsson J, Liljedahl S-O, Schildt B and Fürst P (1980) Biochemical changes associated with severe trauma. Am J Clin Nutr 33:2119–2127
Shaw JFH and Wolfe RR (1987) Energy and protein metabolism in sepsis and trauma. Aust NZ J Surg 57:41–47
FAO/WHO/UNU (1985) Energy and protein requirements. WHO technical report series no 724. Geneva
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Stehle, P., Kuhn, K.S., Fürst, P. (2002). From Structure to Function: What Should Be Known About Building Blocks of Protein. In: Pichard, C., Kudsk, K.A. (eds) From Nutrition Support to Pharmacologic Nutrition in the ICU. Update in Intensive Care Medicine, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57119-0_3
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DOI: https://doi.org/10.1007/978-3-642-57119-0_3
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