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Toxische Schäden des Herzens durch Alkohol, Anthrazykline und Kokain

  • Chapter
Pathologie des Endokard, der Kranzarterien und des Myokard

Part of the book series: Spezielle pathologische Anatomie ((3009,volume 22 / 2))

Zusammenfassung

Eine systematische Abhandlung aller Substanzen, Medikamente und Drogen, die das Herz schädigen können, würde den Rahmen dieses Bandes sprengen. Wir beschränken uns deshalb auf die Besprechung der kardiotoxischen Wirkung des Alkohols, der Antrazykline, denen in der Tumorbehandlung entscheidende Fortschritte zu danken sind, und des Kokains, dem heute vor allem als Droge eine wesentliche Bedeutung zukommt.

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Literatur

A.Alkohol

  • Adams MA, Hirst M (1989) Metroprolol suppresses the development of ethanol-induced cardiac hypertrophy in the rat. Can J Physiol Pharmacol 68:562

    Article  Google Scholar 

  • Adickes ED, Mollner TJ (1986) Ethanol-induced cytoskeletal dysgenesis with dietary protein manipulations. Alcohol Alcoholism 21:347–355

    CAS  Google Scholar 

  • Adickes ED, Mollner TJ (1987) Ethanol-induced cytoskeletal dysgenesis in developing skeletal and cardiac myocytes. Ann NY Acad Sci 492:344–346

    Article  CAS  Google Scholar 

  • Adickes ED, Mollner TJ, Lockwood SK (1990) Ethanol induced morphologic alterations during growth and maturation of cardiac myocytes. Alkohol Clin Exp Res 14:827–831

    Article  CAS  Google Scholar 

  • Adickes ED, Mollner TJ, Makoid MC (1993a) Teratogenic effects of ethanol during hyperplastic growth in cardiac myocyte cultures. Alcohol Clin Exp Res 17:988–992

    Article  PubMed  CAS  Google Scholar 

  • Adickes ED, Mollner TJ, Makoid MC (1993b) Ethanol induced teratogenic alterations in developing cardiomyocytes in culture. Alcohol Alkoholism Suppl 2:283–288

    CAS  Google Scholar 

  • Adickes ED, Mollner TJ, Makoid MC (1993c) Teratogenic effects of ethanol during hyperplastic growth in cardiac myocyte cultures. Alcohol Clin Exp Res 17:988–992

    Article  PubMed  CAS  Google Scholar 

  • Ahmed S, Levinson GE, Regan TJ (1973) Depression of myocardial contractility with low doses of ethanol in normal man. Circulation 48:378–385

    Article  PubMed  CAS  Google Scholar 

  • Alderman EL, Coltart DJ (1982) Alcohol and the heart. Br Med Bull 38:77–80

    PubMed  CAS  Google Scholar 

  • Alexander CS (1966a) Idiopathic heart disease. I. Analysis of 100 cases with special reference to chronic alcoholism. Am J Med 41:213–228

    Article  PubMed  CAS  Google Scholar 

  • Alexander CS (1966b) Idiopathic heart disease. II. Electron microscopic examination of myocardial biopsy specimens in alcoholic heart disease. Am J Med 41:229–234

    Article  PubMed  CAS  Google Scholar 

  • Altura BM, Zou LY, Altura BT, Jelicks L, Wittenberg BA, Gupta RK (1996) Beneficial vs. detrimental actions of ethanol on heart and coronary vascular muscle: roles of Mg2+ and Ca2+. Alcohol 13:499–513

    Article  PubMed  CAS  Google Scholar 

  • Alvarez MR, Clark LC, Moore JA, Morales MC, Gerdes AM (1991) Results of prenatal alcohol exposure on the dimensions and binucleation of cardiac myocytes in neonatal and weanling rats. Teratology 44:395–404

    Article  PubMed  CAS  Google Scholar 

  • Andersson BS, Rajs J, Sundberg, M, Sotonyi P, Lind B (1995) Effect of moderate ethanol intake on the heart: biochemical and morphological studies with isolated cardiomyocytes from rats fed a low-protein diet. J Stud Alcohol 56:147–155

    PubMed  CAS  Google Scholar 

  • Ando H, Abe H, Hisanou R (1993) Ethanol-induced myocardial ischemia: close relation between blood acetaldehyde level and myocardial ischemia. Clin Cardiol 16:443–446

    Article  PubMed  CAS  Google Scholar 

  • Askanas A, Udoshi M, Sadjadi S (1980) The heart in chronic alcoholism: a noninvasive study. Am Heart J 99:9–16

    Article  PubMed  CAS  Google Scholar 

  • Auffermann W, Wu S, Parmley WW, Higgins CB, Wilkman-Coffelt J (1989) Reversibility of chronic alcohol cardiac depression. 31P magnetic resonance spectroscopy in hamsters. Magnet Reson Med 9:343–352

    Article  CAS  Google Scholar 

  • Barboriak JJ, Anderson A, Rimm AA, Tristani FE (1979) Alcohol and coronary arteries. Alcoholism 3:29–32

    PubMed  CAS  Google Scholar 

  • Beckemeier ME, Bora PS (1998) Fatty acid ethyl esters: Potentially toxic products of myocardial ethanol metabolism. J Mol Cell Cardial 30:2487–2494

    Article  CAS  Google Scholar 

  • Beilin LJ, Puddey IB, Burke V (1996) Alcohol and hypertension-kill or cure? J Hum Hypertens 10(Suppl 2):S1-5

    Google Scholar 

  • Bertolet BD, Freund G, Martin CA, Perchalski DL, Williams CM, Pepine CJ (1991) Unrecognized left ventricular dysfunction in an apparently healthy alcohol abuse population. Drug Alcohol Depend 28:113–119

    Article  PubMed  CAS  Google Scholar 

  • Bing RJ (1978) Cardiac metabolism: its contribution to alcoholic heart disease and myocardial failure. Circulation 58:965–970

    Article  PubMed  CAS  Google Scholar 

  • Bing RJ, Tillmanns H, Fauvel J, Seeler K, Mao J (1974) Effect of prolonged alcohol administration on calcium transport in heart muscle of the dog. Circ Res 35:33–38

    Article  PubMed  CAS  Google Scholar 

  • Blomquist G, Saltin B, Mitchell JH (1970) Acute effects of ethanol ingestion on the response to submaximal and maximal exercise in man. Circulation 42:463–470

    Article  Google Scholar 

  • Boffetta P, Garfînkle A (1990) Alcohol drinking and mortality among men enrolled in an American Cancer Society prospective study. Epidemiology 1:342–348

    Article  PubMed  CAS  Google Scholar 

  • Bollinger O von (1884) Über die Häufigkeit und Ursachen der idiopathischen Herzhypertrophie in München. Dtsch Med Wochenschr 10:180

    Article  Google Scholar 

  • Brenn T (1986) The Tromsö Heart Study: alcoholic beverages and coronary risk factors. J Epidemiol Comm Health 40:249–256

    Article  CAS  Google Scholar 

  • Brigden W, Robinson J (1964) Alcoholic heart disease. Br Med J 2:1283–1289

    Article  PubMed  CAS  Google Scholar 

  • Brown RA, Savage AO, Lloyd TC (1996) Acute and chronic effects of ethanol on papillary muscles from spontaneously hypertensive rats. Eur J Pharmacol 302:61–67

    Article  PubMed  CAS  Google Scholar 

  • Buckingham TA, Kennedy HL, Goenjian AK et al. (1985) Cardiac arrhythmias in a population admitted to an acute alcoholic detoxification center. Am Heart J 110:961–965

    Article  PubMed  CAS  Google Scholar 

  • Bulloch RT, Pearce MB, Murphy ML, Jenkins BJ, Davis JL (1972) Myocardial lesions in idiopathic and alcoholic cardiomyopathy. Study by ventricular septal biopsy. Am J Cardiol 29:15–25

    Article  PubMed  CAS  Google Scholar 

  • Burch GE, Colcolough HL, Harb JM, Tsui CY (1971) The effect of ingestion of ethyl alcohol, wine and beer on the myocardium of mice. Am J Cardiol 27:522–528

    Article  PubMed  CAS  Google Scholar 

  • Calabrese V, Rizza V (1999) Effects of L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat. Neurochem Res 24: 79–84

    Article  PubMed  CAS  Google Scholar 

  • Camargo CA jr, Williams PT,Vranizan KM, Albers JJ, Wood PD (1985) The effect of moderate alcohol intake on serum apolipoproteins A-I and A-II. A controlled study. JAMA 253:2854–2857

    Article  PubMed  Google Scholar 

  • Capasso JM, Giancarlo PL, Guideri G, Anversa P (1991) Left ventricular dysfunction induced by chronic alcohol ingestion in rats. Am J Physiol 261: H 212–H 219

    CAS  Google Scholar 

  • Capasso JM, Li P, Guideri G, Malhotra A, Cortese R, Anversa P (1992) Myocardial mechanical, biochemical, and structural alterations induced by chronic ethanol ingestion in rats. Circ Res 71:346–356

    Article  PubMed  CAS  Google Scholar 

  • Cardellach F, Taraschi TF, Ellingson JS et al. (1991) Maintenance of structural and functional characteristics of skeletal-muscle mitochondria and sarcoplasmic-reticular membranes after chronic ethanol treatment. Biochem J 274:565

    PubMed  CAS  Google Scholar 

  • Castelli WP, Doyle JT, Gordon T, Harnes CG, Hjortland MC, Hulley SB et al. (1977) Alcohol and blood lipids: the cooperative lipoprotein phenotyping study. Lancet 2:153–155

    Article  PubMed  CAS  Google Scholar 

  • Cauley JA, Kuller LH, LaPorte RE, Dai WS, D’Antonio JA (1987) Studies on the association between alcohol and high density lipoprotein cholesterol: possible benefits and risks. Adv Alcohol Substance Abuse 6:53–67

    Article  CAS  Google Scholar 

  • Cerqueira MD, Harp GD, Ritchie JL, Stratton JR, Walker RD (1991) Rarity of preclinical alcoholic cardiomyopathy in chronic alcoholics < 40 years of age. Am J Cardiol 67:183–187

    Article  PubMed  CAS  Google Scholar 

  • Chan TCK, Sutter MC (1982) The effects of chronic ethanol consumption on cardiac functions in rats. Can J Physiol Pharmacol 60:777–782

    Article  PubMed  CAS  Google Scholar 

  • Cheng CP, Shihabi Z, Little WC (1990) Acute effects of mildly intoxicating levels of alcohol on left ventricular function in conscious dogs. J Clin Invest 85:1858–1865

    Article  PubMed  CAS  Google Scholar 

  • Child JS, Kovick RB, Levisman JA, Pearce ML (1979) Cardiac effects of acute ethanol ingestion unmasked by autonomie blockade. Circulation 59:120–125

    Article  PubMed  CAS  Google Scholar 

  • Colditz GA, Branch LG, Lipnick RJ et al. (1985) Moderate alcohol and decreased cardiovascular mortality in an elderly cohort. Am Heart J 109:886–889

    Article  PubMed  CAS  Google Scholar 

  • Criqui MH, Ringel BL (1994) Does diet or alcohol explain the french paradox? Lancet 344:1719–1723

    Article  PubMed  CAS  Google Scholar 

  • Criqui MH, Cowan LD, Tyroler HA, Bangdiwala S, Heiss G, Wallace RB, Cohn R (1987) Lipoproteins as mediators for the effects of alcohol consumption and cigarette smoking on cardiovascular mortality: results from the lipid research clinics follow-up study. Am J Epidemiol 126:629–637

    PubMed  CAS  Google Scholar 

  • Cunningham CC, Spach PI (1994) Alcoholism and myocardial energy metabolism. Alcohol Clin Exp Res 18:132–137

    Article  PubMed  CAS  Google Scholar 

  • Cunningham CC, Kouri DL, Beeker KR, Spach PI (1989) Comparison of effects of long-term ethanol consumption on the heart and liver of the rat. Alcohol Clin Exp Res 13:58–65

    Article  PubMed  CAS  Google Scholar 

  • Das AM, Harris DA (1993) Regulation of the mitochondrial ATP synthetase is defective in rat heart during alcohol-induced cardiomyopathy. Biochem Biophys Acta Molec Basis Dis 1181:295–299

    Article  CAS  Google Scholar 

  • Davies MJ (1984) The cardiomyopathies: a review of terminology, pathology and pathogenesis. Histopathology 8:888–893

    Article  Google Scholar 

  • Delgado CE, Fortuin NJ, Ross RS (1975) Acute effects of low doses of alcohol on left ventricular function by echocardiography. Circulation 51:535–540

    Article  PubMed  CAS  Google Scholar 

  • De Makis JG, Proskey A, Rahimtoola SH et al. (1974) The natural course of alcoholic cardiomyopathy. Ann Intern Med 80:293–297

    Article  Google Scholar 

  • Deykin D, Janson P, McMahon L (1982) Ethanol potentiation of aspirin-induced prolongation of the bleeding time. N Engl J Med 306:852–854

    Article  PubMed  CAS  Google Scholar 

  • Diehl AK, Fuller JH, Mattock MB, Salter AM, El-Gohari R, Keen H (1988) The relationship of high density lipoprotein subfractions to alcohol consumption, other lifestyle factors, and coronary heart disease. Atherosclerosis 69:145–153

    Article  PubMed  CAS  Google Scholar 

  • Elmer O, Goransson G, Zoucas E (1984) Impairment of primary hemostasis and platelet function after alcohol ingestion in man. Haemostasis 14:223–228

    PubMed  CAS  Google Scholar 

  • Estruch R, Fernandez-Sola J, Sacanella E, Pare C, Rubin E, Urbano-Marquez A (1995) Relationship between cardiomyopathy and liver disease in chronic alcoholism. Hapatology 22:532–538

    CAS  Google Scholar 

  • Ettinger PO, Wu CF, De la Cruz C, Weisse AB, Ahmed SS, Regan TJ (1978) Arrhythmias and the „Holiday heart syndrome“ alcohol-associated cardiac rhythm disorders. Am Heart J 95:555–562

    Article  PubMed  CAS  Google Scholar 

  • Evans W (1959) The electrocardiogram of alcoholic cardiomyopathy. Br Heart J 21:445–456

    Article  PubMed  CAS  Google Scholar 

  • Factor SM (1976) Intramyocardial small vessel disease in chronic alcoholism. Am Heart J 92:561–575

    Article  PubMed  CAS  Google Scholar 

  • Fahimi HD, Kino M, Hicks L, Thorp KA, Abelman WH (1979) Increased myocardial catalase release in rats fed ethanol. Am J Pathol 96:373–390

    PubMed  CAS  Google Scholar 

  • Farrar R, Ardies C, Shorey R, Erickson C (1982) The interaction of ethanol and swimming upon cardiac mass and mitochondrial function. Pharmacol Biochem Behav 16:207–210

    Article  PubMed  CAS  Google Scholar 

  • Fernandez-Sola J, Estruch R, Nicolas JM, Pare JC, Sacanella E, Antunez E, Urbano-Marquez A (1997) Comparison of alcoholic cardiomyopathy in women versus men. Am J Cardiol 80:481–485

    Article  PubMed  CAS  Google Scholar 

  • Ferrans VJ (1966) Alcoholic cardiomyopathy. Am J Med Sci 252:89–104

    Article  PubMed  CAS  Google Scholar 

  • Ferrans VJ, Buja LM, Roberts WC (1975) Cardiac morphologic changes produced by ethanol. In: Rothschild MA, Oratz M, Schreiber S (eds) Alcohol and abnormal protein biosynthesis. Pergamon Press, New York, p 139

    Google Scholar 

  • Ferrence RG, Truscott S, Whitehead PC (1986) Drinking and the prevention of coronary heart disease: findings, issues and public health policy. J Stud Alcohol 47:394–408

    PubMed  CAS  Google Scholar 

  • Ferrier PE, Nicod I, Ferrier S (1973) Fetal alcohol syndrome. Lancet 2:218

    Google Scholar 

  • Fisher VJ, Kavaler F (1975) The action of ethanol upon the action potential and contraction of ventricular muscle. In: Fleckenstein A, Dhalla NS (eds) Recent advances in studies on cardiac structure and metabolism. Vol 5. University Park Press, Baltimore, pp 415–422

    Google Scholar 

  • Francis GS, Johnson TH, Ziesche S et al. (1990) Marked spontaneous improvement in ejection fraction in patients with congestive heart failure. Am J Med 59:803–807

    Google Scholar 

  • Frankel EN, Kanner J, German JB, Parks E, Kinsella JE (1993) Inhibition in vitro of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 342:454–457

    Article  Google Scholar 

  • Frenzel H, Roth H, Schwartzkopff B (1988) Alkohol und Herz-Kreislaufsystem. Z Gastroenterologie (Suppl 3)26:84–96

    Google Scholar 

  • Fried LP, Moore RD, Pearson TA (1986) Long-term effects of cigarette smoking and moderate alcohol consumption on coronary artery diameter. Am J Med 80:37–44

    Article  PubMed  CAS  Google Scholar 

  • Friedman HS (1992) Cardiovascular effects of ethanol. In: Lieber CS (ed) Medical and nutritional complications of alcoholism. Mechanisms and management. Plenum Press, New York, PP 359–401

    Chapter  Google Scholar 

  • Friedman LA, Kimball AW (1986) Coronary heart disease mortality and alcohol consumption in Framingham. Am J Epidemiol 124:481–489

    PubMed  CAS  Google Scholar 

  • Fuseler JW (1993) Maternal ethanol consumption induces transient compensatory hyperplasia of developing cardiac tissue in the neonatal rat. Alcohol Alcoholism 28:657–666

    CAS  Google Scholar 

  • Gillam E, Ward LC (1986) Cellular energy charge in the heart and liver of the rat. The effects of ethanol and acetaldehyde. Int J Biochem 18:1031–1038

    Article  PubMed  CAS  Google Scholar 

  • Gillet C, Julliere Y, Pirollet P, Aubin HJ, Thouvenin A, Danchin N et al. (1992) Alcohol consumption and biological markers for alcoholism in idiopathic dilated cardiomyopathy: a case-controlled study. Alcohol Alcoholism 27:353–358

    CAS  Google Scholar 

  • Goldstein DB, Chin JH (1981) Interaction of ethanol with biological membranes. Fed Proc 40: 2073–2076

    PubMed  CAS  Google Scholar 

  • Gordon T, Doyle JT (1985) Drinking and coronary heart disease. The Albany Study. Am Heart J 110:331–334

    Article  CAS  Google Scholar 

  • Gordon T, Kannel WB (1983) Drinking habits and cardiovascular disease: The Framingham Study. Am Heart J 105:667–673

    Article  PubMed  CAS  Google Scholar 

  • Gould L, Zahir M, De Martino A et al. (1972a) Hemodynamic effects of ethenaol in patients with cardiac disease. Q J Stud Alcohol 33:714

    PubMed  CAS  Google Scholar 

  • Gould L, Collica C, Zahir M, Gomprecht RF (1972b) Ethyl alcohol. Effects on coronary blood flow in man. Br Heart J 34:815–820

    Article  PubMed  CAS  Google Scholar 

  • Gould L, Reddy CVR, Becker H, Oh KC, Kim SG (1978) Electrophysiologic properties of alcohol in man. J Electrocardiol 11:219–226

    Article  PubMed  CAS  Google Scholar 

  • Gruchow HW, Hoffmann RG, Anderson AJ, Barboriak JJ (1982) Effects of drinking patterns in the relationship between alcohol and coronary occlusion. Atherosclerosis 43:393–404

    Article  PubMed  CAS  Google Scholar 

  • Gruchow HW, Rimm AA, Hoffmann RG (1983) Alcohol consumption and ischémie heart disease mortality: are time-series correlations meaningful? Am J Epidemiol 118:641–650

    PubMed  CAS  Google Scholar 

  • Guarnieri T, Lakatta EG (1990) Mechanism of myocardial contractile depression by clinical concentrations of ethanol. J Clin Invest 85:1462–1467

    Article  PubMed  CAS  Google Scholar 

  • Guillaume P, Jankowski M, Gutkowska J, Gianoulakis C (1996) Effect of chronic moderate ethanol consumption on heart brain natriuretic peptide. Eur J Pharmacol 316:49–58

    Article  PubMed  CAS  Google Scholar 

  • Gunnar RM, Demakis J, Rahimtoola SH et al. (1975) Clinical signs and natural history of alcoholic heart disease. Ann NY Acad Sci 252:264–272

    Article  PubMed  CAS  Google Scholar 

  • Haffner S, Appelbaum-Bowden D, Wahl PW, Hoover JJ, Warnick GR, Albers JJ, Hazzard WR (1985) Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity. Arteriosclerosis 5:169–177

    CAS  Google Scholar 

  • Hall JL, Rowlands DT (1970) Cardiotoxicity of alcohol. Am J Pathol 60:153–164

    PubMed  CAS  Google Scholar 

  • Haller RG, Knöchel JP (1984) Skeletal muscle disease in alcoholism. Med Clin North Am 68:91–103

    PubMed  CAS  Google Scholar 

  • Handa K, Sasaki J, Saku K, Kono S, Arakawa K (1990) Alcohol consumption serum lipids and severity of angiographically determined coronary artery disease. Am J Cardiol 65:287–289

    Article  PubMed  CAS  Google Scholar 

  • Harada S, Agarwal DP, Goedde HW (1980) Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues. Life Sci 26:1773–1780

    Article  PubMed  CAS  Google Scholar 

  • Harcombe A, Ramsay L, Kenna JG, Koskinas J, Why HJF, Richardson PJ et al. (1993) Circulating antibodies to cardiac protein-acetaldehyde adducts in alcoholic heart muscle disease. Clin Sei 88:263–268

    Google Scholar 

  • Härtel G, Louhija A, Konttinen A (1969) Cardiovascular study of 100 chronic alcoholics. Acta Med Scandi 85:507–513

    Google Scholar 

  • Haskell WL, Camargo C jr, Williams PT (1984) The effect of cessation of and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions: a controlled study. N Engl J Med 310:805–810

    Article  PubMed  CAS  Google Scholar 

  • Hastillo AH, Poland J, Hess ML (1980) Mechanical and subcellular function of rat myocardium during chronic ethanol consumption. Proc Soc Exper Biol Med 164:415–420

    CAS  Google Scholar 

  • Heberden W (1786) Some account of a disorder of the breast. Med Trans R Coll Physic 2:59–67

    Google Scholar 

  • Hein HO, Suadicani P, Gyntelberg F (1996) Alcohol consumption, serum low density lipoprotein cholesterol concentration, and risk ischaemic heart disease: six year follow up in the Copenhagen male study. BMJ 312:736–741

    Article  PubMed  CAS  Google Scholar 

  • Hepp A, Schier H, Kochsiek K (1984) Comparative haemodynamic studies on the acute cardiac effects of alcohol in the rat and guinea pig. Eur Heart J 5:85–89

    PubMed  CAS  Google Scholar 

  • Hibbs RG, Ferrans VJ, Black WC, Weilbaecher DG, Walsh JJ, Burch GE (1965) Alcoholic cardiomyopathy. An electron microscopic study. Am Heart J 69:766–779

    Article  PubMed  CAS  Google Scholar 

  • HirotaY, Bing OHL, Abelmann WH (1976) Effect of ethanol on contraction and relaxation of isolated rat ventricular muscle. J Mol Cell Cardiol 8:727–732

    Article  Google Scholar 

  • Hoek JB, Thomas AP, Rooney TA, Higashi K, Rubin E (1992) Ethanol and signal transduction in the liver. FASEB J 6:2386–2396

    PubMed  CAS  Google Scholar 

  • Horton JW, White DJ (1996) Cardiac contractile and sarcoplasmic reticulum function after acute ethanol consumption. J Surg Res 64:132–138

    Article  PubMed  CAS  Google Scholar 

  • Horwitz LD, Atkins JM (1974) Acute effects of ethanol on left ventricular performance. Circulation 49:124–128

    Article  PubMed  CAS  Google Scholar 

  • Howes LG, Reid JL (1986) The effects of alcohol on local, neural, and humoral cardiovascular regulation. Clin Sci 71:9–15

    PubMed  CAS  Google Scholar 

  • Huang RD, Smith MF, Zahler WL (1982) Inhibition of forskolin-activated adenylate cyclase by ethanol and other solvents. J Cyclic Nucl Res 8:385–394

    CAS  Google Scholar 

  • Husain K, Somani SM (1997) Response of cardiac antioxidant system to alcohol and exercise training in the rat. Alcohol 14:301–307

    Article  PubMed  CAS  Google Scholar 

  • Ikram H, Maslowski AH, Smith BL, Nicholls MG (1981) The haemodynamic, histopathological and hormonal features of alcoholic cardiac beriberi. Q J Med 50:369–375

    Google Scholar 

  • Jackson R, Scragg R, Beaglehole R (1991) Alcohol consumption and risk of coronary heart disease. Br Med J 303:211–216

    Article  CAS  Google Scholar 

  • Jackson R, Scragg R, Beaglehole R (1992) Does recent alcohol consumption reduce the risk of myocardial infarction and coronary death in regular drinkers? Am J Epidemiol 136:819–824

    Article  PubMed  CAS  Google Scholar 

  • Jacob AJ, McLaren KM, Boon NA (1991) Effects of abstinence on alcoholic heart muscle disease. Am J Cardiol 68:805–807

    Article  PubMed  CAS  Google Scholar 

  • Jakubowski JA, Vaillancourt R, Deykin D (1988) Interaction of ethanol, prostacyclin, and aspirin determining human platelet reactivity in vitro. Arteriosclerosis 8:436–441

    Article  PubMed  CAS  Google Scholar 

  • James TN, Beer ES (1967) Effects of ethanol and acetaldehyde on the heart. Am Heart J 74:243–255

    Article  PubMed  CAS  Google Scholar 

  • Johnson RA, Palacios I (1982) Dilated cardiomyopathies of the adult. N Engl J Med 307:1051–1058

    Article  PubMed  CAS  Google Scholar 

  • Jones KL, Smith DW (1973) Recognition of the alcohol syndrome in early infancy. Lancet 2:999–1001

    Article  Google Scholar 

  • Jones KL, Smith DW (1975) The fetal alcohol syndrome. Teratology 12:11–26

    Article  Google Scholar 

  • Kagan A, Yano K, Rhoads G, McGee D (1981) Alcohol and cardiovascular disease: The Hawaiian experience. Circulation 64(Suppl III): 27–31

    Google Scholar 

  • Katz AM (1982) Effects of ethanol on ion transport in muscle membranes. FASEB J 41:2456

    CAS  Google Scholar 

  • Kaufmann R, Fleckenstein A (1965) Ca++-kompetitive elektromechanische Entkoppelung durch Ni++ and Co++-Ionen am Warmblütermyokard. Pflügers Arch Ges Physiol 282:290–297

    CAS  Google Scholar 

  • Kelly LF, Goldberg SJ, Donnerstein RL, Cardy MA, Palombo GM (1996) Hemodynamic effects of acute ethanol in young adults. Am J Cardiol 78:851–854

    Article  PubMed  CAS  Google Scholar 

  • Kennedy JM (1998) Mitochondrial gene expression is impaired by ethanol exposure in cultured chick cardiac myocytes. Cardiovasc Res 37:141–150

    Article  PubMed  CAS  Google Scholar 

  • Kikuchi T, Kako KJ (1970) Metabolic effects of ethanol on the rabbit heart. Circ Res 26:625–634

    Article  PubMed  CAS  Google Scholar 

  • King DC, Hirst M (1990) Suppression of ethanol-induced cardiac hypertrophy by ß-adrenoeeptor blockade. J Mol Cell Cardiol 22:523–531

    Article  PubMed  CAS  Google Scholar 

  • Kino M, Imamitchi H, Morigutchi M, Kawamura K, Takatsu T (1981) Cardiovascular status in asymptomatic alcoholics, with reference of the level of ethanol consumption. Br Heart J 46:545–551

    Article  PubMed  CAS  Google Scholar 

  • Klatsky AL (1994) Epidemiology of coronary heart disease-influence of alcohol. Alcohol Clin Exp Res 18:88–96

    Article  PubMed  CAS  Google Scholar 

  • Klatsky AL (1996a) Alcohol and hypertension. Clin Chim Acta 246:91–105

    Article  PubMed  CAS  Google Scholar 

  • Klatsky AL (1996b) Alcohol, coronary disease, and hypertension. Annu Rev Med 47:149–160

    Article  PubMed  CAS  Google Scholar 

  • Klatsky AL, Armstrong MA (1993) Alcoholic beverage choice and risk of coronary artery disease mortality: do red wine drinkers fare best? J Cardiol 71:467–469

    Article  CAS  Google Scholar 

  • Klatsky AL, Friedman GD, Siegelaub AB (1974) Alcohol consumption before myocardial infarction. Results from the Kaiser-Permanente epidemiologic study of myocardial infarction. Ann Intern Med 81:294–301

    Article  PubMed  CAS  Google Scholar 

  • Klatsky AL, Armstrong MA, Friedman GD (1986) Relations of alcoholic beverage use to subsequent coronary artery disease hospitalizations. Am J Cardiol 58:710–714

    Article  PubMed  CAS  Google Scholar 

  • Klein H, Harmjanz D (1975) Effect of ethanol infusion on the ultrastructure of human myocardium. Postgrad Med J 61:325–329

    Article  Google Scholar 

  • Klein H, Spaar U, Kreuzer H (1984) The effect of chronic ethanol consumption on enzyme activities of the energy-supplying metabolism and the alcohol-aldehyde oxidizing system in rat hearts. Basic Res Cardiol 79:238–243

    Article  PubMed  CAS  Google Scholar 

  • Knieriem HJ, Herbertz G (1969) Elektronenmikroskopische Befunde und aktivierungsanalytische Ergebnisse bei experimenteller Herzinsuffizienz durch Kobaltchlorid. Virchows Arch B Zellpathol 2:32–46

    CAS  Google Scholar 

  • Knöchel JP (1988) Cardiovascular effects of alcohol. Ann Intern Med 98:849–854

    Article  Google Scholar 

  • Kobayashi M, Furukawa Y, Chiba S (1979) Effects of ethanol and acetaldehyde on the isolated bloodperfused canine atrium. Arch Intern Pharmacodyn Ther 239:109–120

    CAS  Google Scholar 

  • Komajda M, Richard JL, Bouhour JB et al. (1986) Dilated cardiomyopathy and the level of alcoholic consumption: a planned multicentre case-control study. Eur Heart J 7:512–519

    PubMed  CAS  Google Scholar 

  • Kou S-Y, Cohen NS (1998) Ethanol feeding procedures deficiencies in left ventricle total RNA, total DNA and mitochondrial ribosomal RNA. Int J Biochem Cell Biol 30:475–485

    Article  PubMed  CAS  Google Scholar 

  • Kuhn H, Loogen F (1978) Die Wirkung von Alkohol auf das Herz einschließlich der Alkoholkardiomyopathie. Internist 19:97–106

    PubMed  CAS  Google Scholar 

  • Kupari M, Heikkila J, Tolppanen EM, Nieminen MS, Ylikahri R (1983) Acute effects of alcohol, ß-blockade, and their combination on left ventricular function and hemodynamics in normal man. Eur Heart J 7:463–471

    Google Scholar 

  • Kupari M, Koskinen P, Hynynen M, Salmenera M, Ventila M (1990a) Acute effects of ethanol on left ventricular diastolic function. Br Heart J 64:129–132

    Article  PubMed  CAS  Google Scholar 

  • Kupari M, Koskinen P, Suokas A, Ventila M (1990b) Left ventricular filling impairment in asymptomatic chronic alcoholics. Am J Cardiol 66:1473–1477

    Article  PubMed  CAS  Google Scholar 

  • Landolfi R, Steiner M (1984) Ethanol raises prostacyclin in vivo and in vitro. Blood 64:679–682

    PubMed  CAS  Google Scholar 

  • Lange LG (1991) Mechanism of fatty acid ethyl ester formation and biological significance. Ann NY Acad Sci 625:802–805

    Article  PubMed  CAS  Google Scholar 

  • Langer RD, Criqui MH, Reed DM (1988) Biologic pathways for the effect of moderate alcohol consumption on coronary heart disease. Am J Epidemiol 128:916

    Google Scholar 

  • LaPorte RE, Cresanta JL, Kuller KH (1980) The relationship of alcohol consumption to atherosclerotic heart disease. Prevent Med 9:22–40

    Article  CAS  Google Scholar 

  • Lasker N, Sherrod TR, Killiam KF (1955) Alcohol and the coronary circulation of the dog. J Pharmacol Exp Ther 113:414–420

    PubMed  CAS  Google Scholar 

  • Levi GF, Quadri A, Ratti S, Basagni M (1977) Preclinical abnormality of left ventricular function in chronic alcoholics. Br Heart J 39:35–37

    Article  PubMed  CAS  Google Scholar 

  • Lian C (1915) L’alcoholisme, cause d’hypertension arterielle. Bull Acad Med (Paris) 74:525–528

    Google Scholar 

  • Lieber CS (1987) Microsomal ethanol-oxidizing system. Enzyme 37:45–56

    PubMed  CAS  Google Scholar 

  • Lieber CS (1996) The metabolism of alcohol and its implication to the pathogenesis of disease. In: Preedy VR, Watson RW (eds) Alcohol and the gastrointestinal tract. CRC Press, Boca Raton, PP 19–39

    Google Scholar 

  • Lieber CS, De Carli LM (1982) In liquid diets: two decades of applications and 1982 update. Alcohol Clin Exp Res 6:523–531

    Article  PubMed  CAS  Google Scholar 

  • Lochner A, Cowley R, Brink A (1969) Effect of ethanol on metabolism and function of perfused rat heart. Am Heart J 78:770–780

    Article  PubMed  CAS  Google Scholar 

  • Lorenz R, Janicke-Lorenz J (1984) Ultrastructural studies on experimental alcoholic heart disease in rats. Z Versuchstierk 26:151–156

    CAS  Google Scholar 

  • Loser H, Majewski F (1977) Type and frequency of cardiac defects in embryofetal alcohol syndrome. Report of 16 cases. Br Heart J 39:1374–1379

    Article  PubMed  CAS  Google Scholar 

  • Lowenstein SR, Gabow PA, Cramer J, Oliva PA, Ratner K (1983) The role of alcohol in new-onset atrial fibrillation. Arch Intern Med 143:1882–1885

    Article  PubMed  CAS  Google Scholar 

  • Ma X, Wearne K, Lynch WJ, Maserei JRL (1989) Apolipoprotein A-I and A-II levels in an australian population. Pathology 21:42–45

    Article  PubMed  CAS  Google Scholar 

  • MacMahon S (1987) Alcohol consumption and hypertension. Hypertension 9:111–121

    Article  PubMed  CAS  Google Scholar 

  • Mall G, Mattfeldt T, Volk B (1980) Ultrastructural morphometric study on the rat heart after chronic ethanol feeding. Virchows Arch A Pathol Anat Histol 389: 59–77

    Article  PubMed  CAS  Google Scholar 

  • Marmot MG (1984) Alcohol and coronary heart system. Internat J Epidemiol 13:160–167

    Article  CAS  Google Scholar 

  • Mattfeldt T, Mall G, Volk B (1980) Morphometric analysis of rat heart mitochondria after chronic ethanol treatment. J Mol Cell Cardiol 12:1311–1319

    Article  PubMed  CAS  Google Scholar 

  • Mathews JD (1976) Alcohol use, hypertension and coronary heart disease. Clin Sci Molec Med 51: 661s-663s

    Google Scholar 

  • Matthews EC, Gardin JM, Henry WL, Del Negro AA, Fletcher RD, Snow JA, Epstein SE (1981) Echocardiographic abnormalities in chronic alcoholics with and without overt congestive heart failure. Am J Cardiol 47:570–578

    Article  Google Scholar 

  • Meade TW, Chakrabarti R, Haines AP, North WRS, Stirling Y (1979) Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. Br Med J 1:153–156

    Article  PubMed  CAS  Google Scholar 

  • Menz V, Grimm W, Hoffmann J, Maisch B (1996) Alcohol and rhythm disturbance: the holiday heart syndrome. Herz 21:227–231

    PubMed  CAS  Google Scholar 

  • Mikami K, Sato S, Nakazawa N, Asano G, Watanabe T (1993) Ethanol-elicited structural and biochemical alterations in mitochondrial ATPase in cultured myocardial cells. Virchows Arch B Zellpathol 63:365–371

    Article  CAS  Google Scholar 

  • Mikhailidis DP, Jeremy JY, Barradas MA, Green N, Dandona P (1983) Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation, and platelet thromboxane release. Br Med J 287:1495–1498

    Article  CAS  Google Scholar 

  • Moore RD, Pearson TA (1986) Moderate alcohol consumption and coronary artery disease. Medicine 65:242–267

    Article  PubMed  CAS  Google Scholar 

  • Morvai V, Ungvary G (1987) Morphological alterations due to long term alcohol intake in rats. Exp Pathol 31:153–160

    Article  PubMed  CAS  Google Scholar 

  • Moushmoush B, Abi-Mansour P (1991) Alcohol and the heart. The long-term effects of alcohol on the cardiovascular system. Arch Intern Med 151:38–42

    Article  Google Scholar 

  • Müller-Höcker J (1994) Molekularpathologie mitochondrialer Funktionsstörungen. Verh Dtsch Ges Pathol 78:48–93

    PubMed  Google Scholar 

  • Münzinger (1877) Das Tübinger Herz. Ein Beitrag zur Lehre von der Überanstrengung des Herzens. Dtsch Arch f klin Med 19:449

    Google Scholar 

  • Nakamura K, Kouchi H, Ohe T, Namba M (1999) Increase in beating rate of cultured chick cardiac myocytes by ethanol and inhibition of the increase by antiarrhythmic drugs. Alcohol Clin Exp Res 23(Suppl):81S–84S

    Article  PubMed  CAS  Google Scholar 

  • Nicolas JM, Rubin E, Thomas AP (1996) Ethanol and cocaine cause additive inhibitory effects on the calcium transients and contraction in single cardiomyocytes. Alcohol Clin Exp Res 20: 1077–1082

    Article  PubMed  CAS  Google Scholar 

  • Omodeo-Sale F, Lindi C, Palestini P, Masserini M (1991) Role of phosphatidylethanol in membranes. Effects on membrane fluidity, tolerance to ethanol, and activity of membrane-bound enzymes. Biochemistry 30:2477–2482

    Article  PubMed  CAS  Google Scholar 

  • Orlando J, Aronow WS, Cassidy J, Prakash R (1976) Effect of ethanol on angina pectoris. Ann Intern Med 84:652–655

    Article  PubMed  CAS  Google Scholar 

  • Otero-Anton E, Gonzales-Quintela A, Saborido J, Torre JA, Virgos A, Barrio E (1997) Prolongation of the QTc interval during alcohol withdrawal syndrome. Acta Cardiol 52:285–294

    PubMed  CAS  Google Scholar 

  • Pachinger OM, Tillmanns H, Mao J, Fauvel JM, Bing RJ (1973) The effects of prolonged administration of ethanol on cardiac metabolism and performance in the dog. J Clin Invest 52:2690–2696

    Article  PubMed  CAS  Google Scholar 

  • Panos RJ, Sutton FJ, Yong-Hyman P, Peters R (1988) Sudden death associated with alcohol consumption. PACE 11:423–424

    Article  PubMed  CAS  Google Scholar 

  • Patel R, Me Ardle JJ, Regan TJ (1991) Increased ventricular vulnerability in a chronic ethanol model despite reduced electrophysiologic responses to catecholamines. Alcohol Clin Exp Res 15: 785–789

    Article  PubMed  CAS  Google Scholar 

  • Patel VB, Corbett JM, Richardson PJ, Dunn MJ, Preedy VR (1995a) Chronic effects of alcohol upon protein profiling in ventricular tissue. Biochem Soc Transact 23:461s

    Google Scholar 

  • Patel VB, Sherwood R, Why H, Poyser K, Richardson PJ, Preedy VR (1995b) The acute and chronic effects of alcohol toxicity upon rat plasma troponin-T levels. Alcohol Alcoholism 30:525

    Google Scholar 

  • Patel YB, Why HJ, Richardson PJ, Preedy VR (1997) The effects of alcohol on the heart. Adv Drug React Toxicol Rev 16:15–43

    CAS  Google Scholar 

  • Paz R, Jortner R, Tunick PA, Sclarovsky S, Eilat B, Perez JL, Kronzon I (1996) The effect of the ingestion of ethanol on obstruction of the left ventricular outflow tract in hypertrophie cardiomyopathy. N Engl J Med 335:938–941

    Article  PubMed  CAS  Google Scholar 

  • Pescio S, Macho P, Penna M, Domenech RJ (1983) Changes in total and transmural coronary blood flow induced by ethanol. Cardiovasc Res 17:604–607

    Article  PubMed  CAS  Google Scholar 

  • Peters TJ, Wells G, Oakley CM, Brooksby IAB, Jenkins BS, Webb-Peploe MM, Coltart DJ (1977) Enzymatic analysis of endomyocardial biopsy specimens from patients with cardiomyopathies. Br Heart J 39:1333–1339

    Article  PubMed  CAS  Google Scholar 

  • Pintar K, Wolanskyj BM, Buggay ER (1965) Alcoholic cardiomyopathy. Can Med Ass J 390:103

    Google Scholar 

  • Prazak P, Pfisterer M, Osswald S, Buser P, Burkart F (1996) Differences of disease progression in congestive heart failure due to alcoholic as compared to idiopathic dilated cardiomyopathy. Eur Heart J 17:251–257

    Article  PubMed  CAS  Google Scholar 

  • Preedy VR, Peters TJ (1989) Synthesis of subcellular protein fractions in the rat heart in vivo in response to chronic ethanol feeding. Cardiovasc Res 23:730–736

    Article  PubMed  CAS  Google Scholar 

  • Preedy VR, Peters TJ (1990) The acute and chronic effects of ethanol on cardiac muscle protein synthesis in the rat in vivo. Alcohol 7:97–102

    Article  PubMed  CAS  Google Scholar 

  • Preedy VR, Peters TJ (1992) Protein metabolism in alcoholism. In: Wutson RR, Watzl B (eds) Nutrition and alcohol. CHC Press, Boca Raton, pp 143–189

    Google Scholar 

  • Preedy VR, Richardson PJ (1996) Alcoholic cardiomyopathy: clinical and experimental pathological changes. Herz 21:241–247

    PubMed  CAS  Google Scholar 

  • Preedy VR, Duane P, Peters TJ (1988) Biological effects of chronic ethanol consumption. A reappraisal of the Lieber-DeCarli liquid diet model with reference to skeletal muscle. Alcohol Alcoholism 23:151–154

    CAS  Google Scholar 

  • Preedy VR, Siddiq T, Cook F, Black D, Palmer TN, Peters TJ (1991) Alcohol and protein turnover. In: Palmer TN (ed) Alcoholism: a molecular perspective. Plenum Press, New York, pp 253–273

    Chapter  Google Scholar 

  • Preedy VR, Atkinson LM, Richardson PJ, Peters TJ (1993) Mechanisms of ethanol-induced cardiac damage. Br Heart J 69:197–200

    Article  PubMed  CAS  Google Scholar 

  • Preedy VR, Siddiq T, Why HJF, Richardson PJ (1994) Ethanol toxicity and cardiac protein synthesis in vivo. Am Heart J 127:1432–1439

    Article  PubMed  CAS  Google Scholar 

  • Puszkin S, Rubin E (1975) Adenosine diphosphate effect on contractility of human muscle. Actomyosin: Inhibition by ethanol and acetaldehyde. Science 188:1319–1320

    Article  PubMed  CAS  Google Scholar 

  • Regan TJ (1971) Ethyl alcohol and the heart. Circulation 44:957

    Article  PubMed  CAS  Google Scholar 

  • Regan TJ (1984) Alcoholic cardiomyopathy. Prog Cardiol Dis 27:141

    Article  CAS  Google Scholar 

  • Regan TJ (1990) Alcohol and the cardiovascular system. JAMA 264:377–381

    Article  PubMed  CAS  Google Scholar 

  • Regan TJ, Morvai V (1987) Experimental models for studying the effects of ethanol on the myocardium. Acta Med Scand (Suppl) 717:107–113

    CAS  Google Scholar 

  • Regan TJ, Koroxenidis G, Moschos CB et al. (1966) The acute metabolic and hemodynamic responses of the left ventricle to ethanol. J Clin Invest 45:270

    Article  PubMed  CAS  Google Scholar 

  • Regan TJ, Levinson GE, Oldewurtel HA, Frank MJ, Weisse AB, Moschos CB (1969) Ventricular function in noncardiacs with alcoholic fatty liver: role of ethanol in the production of cardiomyopathy. J Clin Invest 48:397–407

    Article  PubMed  CAS  Google Scholar 

  • Regan TJ, Khan MI, Ettinger PO, Haider B, Lyons MM, Oldewurtel HA (1974) Myocardial function and lipid metabolism in the chronic alcoholic animal. J Clin Invest 54:740–752

    Article  PubMed  CAS  Google Scholar 

  • Regan TJ, Ettinger PO, Haider B et al. (1977) The role of ethanol in cardiac disease. Ann Rev Med 28:393

    Article  PubMed  CAS  Google Scholar 

  • Renaud SC, Ruf JC (1996) Effects of alcohol on platelet functions. Clin Chim Acta 246:77–89

    Article  PubMed  CAS  Google Scholar 

  • Renaud SC, Beswick AD, Fehily AM, Sharp DS, Elwood PC (1992) Alcohol and platelet aggregation: the caerphilly prospective heart disease study. Am J Clin Nutr 55:1012–1017

    PubMed  CAS  Google Scholar 

  • Rich EC, Siebold C, Campion B (1985) Alcohol-related acute atrial fibrillation. A case control study and review of 40 patients. Arch Intern Med 145:830–833

    Article  PubMed  CAS  Google Scholar 

  • Richardson PJ, Wodak AD (1983) Alcohol-induced heart muscle disease. In: Symons C, Evans T, Mitchell AG (eds) Specific heart muscle disease. Wright, Bristol, pp 99–122

    Google Scholar 

  • Richardson PJ, Wodak AD, Atkinson L, Saunders JB, Jewitt DE (1986) Relation between alcohol intake, myocardial enzyme activity, and myocardial function in dilated cardiomyopathy. Evidence for the concept of alcohol induced heart muscle disease. Br Heart J 56:165–170

    Article  PubMed  CAS  Google Scholar 

  • Riff DP, Jain AC, Doyle JT (1969) Acute hemodynamic effects of ethanol on normal human volunteers. Am Heart J 78:592–597

    Article  PubMed  CAS  Google Scholar 

  • Rifkind BM (1990) High-density lipoprotein cholesterol and coronary artery disease: survey of the evidence. Am J Cardiol 66:3 A–6 A

    Article  CAS  Google Scholar 

  • Rimm EB, Klatsky A, Grobbee D, Stampfer MJ (1996) Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits. BMJ 312:731–736

    Article  PubMed  CAS  Google Scholar 

  • Robishaw JD, Hansen CA (1994) Structure and function of G proteins mediating signal transduction pathways in the heart. Alcohol Clin Exp Res 18:115–120

    Article  PubMed  CAS  Google Scholar 

  • Rohan TE (1984) Alcohol and ischémie heart disease: a review. Aust NZ J Med 14:75–80

    Article  CAS  Google Scholar 

  • Rossi M (1980) Alcohol and malnutrition in the pathogenesis of experimental alcoholic cardiomyopathy. J Pathol 130:105–116

    Article  PubMed  CAS  Google Scholar 

  • Rubin E (1979) Alcoholic myopathy in heart and skeletal muscle. N Engl J Med 301:28–33

    Article  PubMed  CAS  Google Scholar 

  • Rubin E, Goldschlager N (1970) Persistence of low cardiac output after relief of high output by thiamine in a case of alcoholic beri-beri and cardiac myopathy. Am Heart J 80:103

    Article  Google Scholar 

  • Rubin E, Thomas AP (1992) Effects of alcohol on the heart and cardiovascular system. In: Mendelson JH, Mello NK (eds) Medical diagnosis and treatment of alcoholism. McGraw-Hill, New York, pp 263–287

    Google Scholar 

  • Rubin E, Urbano-Marquez A (1994) Alcoholic Cardiomyopathy. Alcohol Clin Exp Res 18:111–114

    Article  PubMed  CAS  Google Scholar 

  • Rupp H, Brilla CG, Maisch B (1996) Hypertonie und Alkohol: zentrale und periphere Mechanismen. Herz 21:258–264

    PubMed  CAS  Google Scholar 

  • Russek HI, Naegele CF, Regan FD (1956) Alcohol in the treatment of angina pectoris. JAMA 143: 355–357

    Article  Google Scholar 

  • Sardesai V, Provido H (1978) The effect of chronic ethanol ingestion on myocardial glucose and energy metabolism. J Nutr 108:1907–1912

    PubMed  CAS  Google Scholar 

  • Sarma JSM, Ikeda S, Fisher R, Maruyama Y, Weishaar R, Bing RJ (1976) Biochemical and contractile properties of heart muscle after prolonged alcohol administration. J Mol Cell Cardiol 8:951–972

    Article  PubMed  CAS  Google Scholar 

  • Saunders JB, Beevers DG, Paton A (1981) Alcohol-induced hypertension. Lancet II: 653–656

    Article  Google Scholar 

  • Schneider J, Kaffarnik H, Steinmetz A (1996) Alkohol, Fettstoffwechsel und koronare Herzkrankheit. Herz 21:217–226

    PubMed  CAS  Google Scholar 

  • Schreiber SS, Briden J, Oratz M, Rothschild MA (1972) Ethanol, acetaldehyde and myocardial protein synthesis. J Clin Invest 51:2820–2826

    Article  PubMed  CAS  Google Scholar 

  • Schreiber SS, Oratz M, Rothschild MA, Reef F, Evans C (1974) Alcoholic cardiomyopathy. IL The inhibiton of cardiac microsomal protein synthesis by acetaldehyde. J Mol Cell Cardiol 6: 207–213

    Article  PubMed  CAS  Google Scholar 

  • Schulman SP, Lakatta EG, Weiss RG, Wolff MR, Hano O, Gerstenblith G (1991) Contractile metabolic and electrophysiologic effects of ethanol in the isolated rat heart. J Mol Cell Cardiol 23:417–426

    Article  PubMed  CAS  Google Scholar 

  • Schultheiss H, Spiegel M, Boite H (1985) The effects of chronic ethanol treatment on oligomycin sensitive ATPase activity in the guinea pig heart. Basic Res Cardiol 80:548–555

    Article  PubMed  CAS  Google Scholar 

  • Schwartz A (1976) Cell membrane Na+, K+-ATPase and sarcoplasmic reticulum: possible regulators of intracellularion activity. Fed Proc 35:1279–1282

    PubMed  CAS  Google Scholar 

  • Segel LD (1988) Tolerance to ethanol and cross-tolerance to pentobarbital by isolated hearts from chronic alcoholic rats. Alcohol Clin Exp Res 12:523–530

    Article  PubMed  CAS  Google Scholar 

  • Segel LD, Mason D (1982) Beta-adrenergic receptors in chronic alcoholic rat hearts. Cardiovasc Res 16:34–39

    Article  PubMed  CAS  Google Scholar 

  • Segel LD, Rendig SV, Choquet Y, Chacko K, Amsterdam EA, Mason DT (1975) Effects of chronic graded ethanol consumption on the metabolism, ultrastructure, and mechanical function of the rat hearts. Cardiovasc Res 9:649–663

    Article  PubMed  CAS  Google Scholar 

  • Segel LD, Rendig SV, Mason DT (1979) Left ventricular dysfunction of isolated working rat hearts after chronic alcohol consumption. Cardiovasc Res 13:136–146

    Article  PubMed  CAS  Google Scholar 

  • Segel LD, Rendig SV, Mason DT (1981) Alcoholic-induced cardiac hemodynamic and Ca2+-flux dysfunctions are reversible. J Mol Cell Cardiol 13:433–455

    Article  Google Scholar 

  • Seigneur M, Bonnet J, Dorian B, Benchimol D, Drouillet F, Gouverneur G et al. (1990) Effect of the consumption of alcohol, white wine, and red wine on platelet function and serum lipids. J Appl Cardiol 5:215–222

    Google Scholar 

  • Shaper AG, Wannamethee G, Walker M (1988) Alcohol and mortality in british men: explaining the U-shaped curve. Lancet 2:1267–1273

    Article  PubMed  CAS  Google Scholar 

  • Siddiq T, Richardson PJ, Mitchell WD, Teare J, Preedy VR (1993a) Ethanol-induced inhibition of ventricular protein synthesis in vivo and the possible role of acetaldehyde. Cell Biochem Funct n:45–54

    Google Scholar 

  • Siddiq T, Richardson PJ, Morton J, Smith B, Sherwood RA, Marway JS, Preedy VR (1993b) Rates of protein synthesis in different regions of the normotensive and hypertrophied heart in response to acute alcohol toxicity. Alcohol Alcoholism 28:297–310

    CAS  Google Scholar 

  • Siddiq T, Salisbury JR, Richardson PJ, Preedy VR (1993c) Synthesis of ventricular mitochondrial proteins in vivo: effect of acute ethanol toxicity. Alcoholism 17:894–899

    PubMed  CAS  Google Scholar 

  • Siddiq T, Sandhu G, Richardson PJ, Preedy VR (1997) Effects of acute ethanol on ventricular myofibrillary protein synthesis in vivo in normotensive and hypertensive rats. Addict Biol 2: 87–93

    Article  CAS  Google Scholar 

  • Sieman EH, Creasy LL (1992) Concentration of the phytoalexin resveratrol in wine. Am J Enol Viticulture 43:1–4

    Google Scholar 

  • Sipila R (1985) Atrial fibrillation precipitated by alcohol. Lancet i: 391–392

    Article  Google Scholar 

  • Siscovick DS, Weiss NS, Fox N (1986) Moderate alcohol consumption and primary cardiac arrest. Am J Epidemiol 123:499–503

    PubMed  CAS  Google Scholar 

  • Slavin G, Martin F, Wand P, Levi J, Peters T (1983) Chronic alcohol excess is associated with selective but reversible injury to typ 2B muscle fibres. J Clin Pathol 36:772–777

    Article  PubMed  CAS  Google Scholar 

  • Spodick DH, Pigott VM, Chirife R (1972) Predinical cardiac malfunction in chronic alcoholism. Comparison with matched normal controls and with chronic alcoholism. N Engl J Med 287: 677–680

    Article  PubMed  CAS  Google Scholar 

  • Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH (1988) Prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med 319:267–273

    Article  PubMed  CAS  Google Scholar 

  • Standen DJ, Salvatici RP, Cabezas ME, Schulz CS, Torres CS, Carpentier RG (1997) Actions and interactions of ethanol and imipramine on the rat sinus node. Int J Cardiol 60:165–170

    Article  PubMed  CAS  Google Scholar 

  • Steeg CN, Woolf P (1979) Cardiovascular malformations in the fetal alcohol syndrome. Am Heart J 98:635–637

    Article  PubMed  CAS  Google Scholar 

  • Steinberg JD, Hayden MT (1981) Prevalence of clinically occult cardiomyopathy in chronic alcoholism. Am Heart J 101:461–464

    Article  PubMed  CAS  Google Scholar 

  • St Leger AS, Cochrane AL, Moore F (1979) Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1:1017–1020

    Article  PubMed  CAS  Google Scholar 

  • Suh I, Shaten J, Cutler JA, Kuller KH (1992) Alcohol use and mortality from coronary heart disease: the role high-density-lipoprotein cholesterol. Ann Intern Med 116:881–887

    Article  PubMed  CAS  Google Scholar 

  • Syslak PH, Nathaniel EJH, Novak C, Burton L (1994) Fetal alcohol effects on the postnatal development of the rat myocardium: an ultrastructural and morphometric analysis. Exp Mol Pathol 60:158–172

    Article  PubMed  CAS  Google Scholar 

  • Taraschi TF, Rubin E (1985) Effects of ethanol on the chemical and structural properties of histologic membranes. Lab Invest 52:120

    PubMed  CAS  Google Scholar 

  • Tepper D, Capasso JM, Sonnenblick EH (1986) Excitation-contraction coupling in rat myocardium: alterations with long-term ethanol consumption. Cardiovasc Res 20:369–374

    Article  PubMed  CAS  Google Scholar 

  • Teragaki M, Takeuchi K, Takeda T (1993) Clinical and histologie features of alcohol drinkers with congestive heart failure. Am Heart J 125:808–817

    Article  PubMed  CAS  Google Scholar 

  • Thomas AP, Rozanski DJ, Renard DC, Rubin E (1994) Effects of ethanol on the contractile function of the heart: a review. Alcohol Clin Exp Res 18:121–131

    Article  PubMed  CAS  Google Scholar 

  • Thomas G, Haider B, Oldewurtel HA, Lyons MM,Yeh CK, Regan TJ (1980) Progression of myocardial abnormalities in experimental alcoholism. Am J Cardiol 46:233–241

    Article  PubMed  CAS  Google Scholar 

  • Thornton JR (1984) Atrial fibrillation in healthy non-alcoholic people after an alcoholic binge. Lancet ii: 1013–1014

    Article  Google Scholar 

  • Tiernan JM, Ward LC (1986) Acute effects of ethanol on protein synthesis in the rat. Alcohol Alcoholism 21:171–179

    CAS  Google Scholar 

  • Tiernan JM, Ward LC, Cooksley WGE (1985) Inhibition by ethanol of cardiac protein synthesis in the rat. Int J Biochem 17:793–798

    Article  PubMed  CAS  Google Scholar 

  • Uphoff C, Nyquist-Battie C, Roth T (1984) Cardiac muscle development in mice exposed to ethanol in utero. Teratology 30:119–129

    Article  PubMed  CAS  Google Scholar 

  • Urbano-Marquez A, Estruch R, Navarro-Lopez F, Grau JM, Mont L, Rubin E (1989) The effects of alcoholism on skeletal and cardiac muscle. N Engl J Med 320:409–415

    Article  PubMed  CAS  Google Scholar 

  • Valamiki M, Nikkila EA, Taskinen A (1986) Rapid decrease in high density lipoprotein subfractions and post heparin plasma lipase activity after cessation of chronic alcohol intake. Atherosclerosis 59:147–153

    Article  Google Scholar 

  • Vikhert AM, Tsiplenkova VG, Cherpachenko NM (1986) Alcoholic cardiomyopathy and sudden cardiac death. J Am Coll Cardiol 8:3A–11A

    Article  PubMed  CAS  Google Scholar 

  • Watt AH (1985) Atrial fibrillation and alcohol. Lancet i: 162

    Article  Google Scholar 

  • Webb WR, Degerli JU (1965) Ethyl alcohol and the cardiovascular system. Effects on coronary blood flow. JAMA 191:1055

    Article  PubMed  CAS  Google Scholar 

  • Weishaar R, Sarma JSM, Maruyama Y et al. (1977) Reversibility of mitochondrial and contractile changes in the myocardium after cessation of prolonged ethanol intake. Am J Cardiol 40: 556–562

    Article  PubMed  CAS  Google Scholar 

  • Weishaar R, Bertuglia S, Ashikawa K, Sarma J, Bing R (1978) Comparative effects of chronic ethanol and acetaldehyde exposure on myocardial function in rats. J Clin Pharmacol 18:377–387

    Article  PubMed  CAS  Google Scholar 

  • Whitman V, Musselman J, Schüler H, Fuller E (1980) Metabolic and functional consequences of chronic alcoholism on the rat heart. J Mol Cell Cardiol 12:1249–1262

    Article  PubMed  CAS  Google Scholar 

  • Wilke A, Kaiser A, Ferency I, Maisch B (1996) Alkohol und Myokarditis. Herz 21:248–257

    PubMed  CAS  Google Scholar 

  • Williams ES, Mirro MJ, Bailey JC (1980) Electrophysiological effects of ethanol, acetyldehyde, and acetate on cardiac tissues from dog and guinea pig. Circ Res 47:473–478

    Article  PubMed  CAS  Google Scholar 

  • Williams JW, Tada M, Katz AM, Rubin E (1975) Effect of ethanol and acetaldehyde on the (Na+ + K+activated adenosine triphosphatase activity of cardiac plasma membranes. Biochem Pharmacol 24:27–32

    Article  PubMed  CAS  Google Scholar 

  • Wong M (1973) Depression of cardiac peformance by ethanol unmasked during autonomic blockade. Am Heart J 86:508–515

    Article  PubMed  CAS  Google Scholar 

  • Wu CF, Sudhakar M, Jaferi G, Ahmed SS, Regan TJ (1976) Preclinical cardiomyopathy in chronic alcoholics: a sex difference. Am Heart J 91: 281–286

    Article  PubMed  CAS  Google Scholar 

  • Yano K, Rhoads GG, Kagan A (1977) Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii. N Engl J Med 297:405–409

    Article  PubMed  CAS  Google Scholar 

  • Zakkari S (1991) Vulnerability to cardiac disease. Rec Dev Alcohol 9:225–260

    Google Scholar 

B. Antrazykline

  • Alexander J, Dainiak N, Berger HJ, Goldman L, Johnstone D, Reduto L et al. (1979) Serial assessment of doxorubicin cardiotoxicity with quantitative radionudide angiocardiography. N Engl J Med 300:278–283

    Article  PubMed  CAS  Google Scholar 

  • Billingham ME, Mason JW, Bristow MR, Daniels JR (1978) Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep 62:865–872

    PubMed  CAS  Google Scholar 

  • Bossa R, Bissoli M, Chiericozzi M, Cozzi R, Galatulas I, Salvatore G (1996) Reduction of Adriamycin cardiotoxicity bei Enoximone. Anticancer Res 16:141–144

    PubMed  CAS  Google Scholar 

  • Bristow MR, Mason JW, Billingham ME, Daniels JR (1978) Doxorubicin cardiomyopathy: evaluation by phonocardiography, endomyocardial biopsy, and cardiac catheterization. Ann Int Med 88: 168–175

    Article  PubMed  CAS  Google Scholar 

  • Bristow MR, Mason JW, Billingham ME, Daniels JR (1981) Dose-effect and structure-function relationships in doxorubicin cardiomyopathy. Am Heart J 102:709–718

    Article  PubMed  CAS  Google Scholar 

  • Buja LM, Ferrans VJ, Mayer RJ, Roberts WC, Henderson ES (1973) Cardiac ultrastructural changes induced by daunorubicin therapy. Cancer 32:771–788

    Article  PubMed  CAS  Google Scholar 

  • Cappelli V, Moggio R, Monti E, Paracchini L, Piccinini F, Reggiani C (1989) Reduction of myofibrillar ATPase activity and isomyosin shift in delayed doxorubicin cardiotoxicity. J Mol Cell Cardiol 21:93–101

    Article  PubMed  CAS  Google Scholar 

  • Caroni P, Villani F, Carafoli E (1981) The cardiotoxic antibiotic doxorubicin inhibits the Na+/Ca++ exchange of dog heart sarcolemmal vesicles. FEBS Lett 130:184–186

    Article  PubMed  CAS  Google Scholar 

  • Carrio I, Estorch M, Lopez-Pousa A (1996) Assessing anthracycline cardiotoxicity in the 1990s. Eur J Nud Med 23:359–364

    Article  CAS  Google Scholar 

  • Caulfield JB, Bittner V (1988) Cardiac matrix alterations induced by adriamycin. Am J Pathol 133: 298–305

    PubMed  CAS  Google Scholar 

  • Estorch M, Carrio I, Martinez-Duncker D, Berna L, Torres G, Alonso C, Ojeda B (1993) Myocyte cell damage after administration of doxorubicin or mitoxantrone in breast cancer patients assessed by indium 111 antimyosin monoclonal antibody studies. J Clin Oncol 11:1264–1268

    PubMed  CAS  Google Scholar 

  • Fajardo LF, Eltringham JR, Stewart JR (1976) Combined cardiotoxicity of adriamycin and X-radiation. Lab Invest 34:86–96

    PubMed  CAS  Google Scholar 

  • Ferrari R, Bachetti T, Confortini R, Opasich C, Febo O, Corti A et al. (1985) Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. Circulation 92:1479–1486

    Article  Google Scholar 

  • Fréter CE, Lee TC, Billingham ME, Chak L, Bristow MR (1986) Doxorubicin cardiac toxicity manifesting seven years after treatment. Case report and review. Am J Med 80:483–485

    Article  PubMed  Google Scholar 

  • Goorin AM, Borow KM, Goldman A, Williams RG, Henderson IC, Sallan SE et al. (1981) Congestive heart failure due to adriamycin cardiotoxicity: its natural history in children. Cancer 47: 2810–2816

    Article  PubMed  CAS  Google Scholar 

  • Goorin AM, Chauvenet AR, Perez-Atayde AR, Cruz J, McKone R, Lipshultz SE (1990) Initial congestive heart failure, six to ten years after doxorubicin chemotherapy for childhood cancer. J Pediatr 116:144–147

    Article  PubMed  CAS  Google Scholar 

  • Hale JP, Lewis IJ (1994) Anthracyclines: cardiotoxicity and its prevention. Arch Dis Childhood 71:457–462

    Article  CAS  Google Scholar 

  • Henderson IC, Sloss LJ, Jaffe N, Blum RH, Frei E, III (1978) Serial studies of cardiac function in patients receiving adriamycin. Cancer Treat Rep 62:23–29

    Google Scholar 

  • Herman EH, Lipshultz SE, Rifai N, Zhang J, Papoian T, Yu ZX et al. (1998) Use of cardiac Troponin T levels as an indicator of Doxorubicin-induced cardiotoxicity. Cancer Res 58:195–197

    PubMed  CAS  Google Scholar 

  • Hershko C, Pinson A, Link G (1996) Prevention of anthracycline cardiotoxicity by iron chelation. Acta Haematol 95: 87–92

    Article  PubMed  CAS  Google Scholar 

  • Hoff DD von, Rozenczweig M, Layard M, Slavik M, Muggia FM (1977) Daunomycin-induced cardiotoxicity in children and adults. A review of 110 cases. Am J Med 62:200–208

    Article  Google Scholar 

  • Hoff DD von, Layard MW, Basa P, Davis HL jr, Hoff AL von, Rozencweig M et al. (1979) Risk factors for doxorubicin-induced congestive heart failure. Ann Int Med 91:710–717

    Article  Google Scholar 

  • Ito H, Miller SC, Billingham ME, Akimoto H, Torti SV, Wade R et al. (1990) Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro. Proc Natl Acad Sci 87:4275–4279

    Article  PubMed  CAS  Google Scholar 

  • Jaenke RS (1976) Delayed and progressive myocardial lesions after adriamycin administration in the rabbit. Cancer Res 36:2958–2966

    PubMed  CAS  Google Scholar 

  • Kantrowitz NE, Bristow MR (1984) Cardiotoxicity of antitumor agents. Progr Cardiovasc Dis 27: 195–200

    Article  CAS  Google Scholar 

  • Lampidis TJ, Henderson IC, Israel M, Canellos GP (1980) Structural and functional effects of adriamycin on cardiac cells in vitro. Cancer Res 40:3901–3909

    PubMed  CAS  Google Scholar 

  • Lipshultz SE, Colan SD, Gelber RD, Perez-Atayde AR, Sallan SE, Sanders SP (1991) Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood. New Engl J Med 324: 808–815

    Article  PubMed  CAS  Google Scholar 

  • Maron BJ, Roberts WC (1981) Cardiomyopathies in the first two decades of life. Cardiovasc Clin 11:35–78

    PubMed  CAS  Google Scholar 

  • Matsumori A, Yamada T, Suzuki H, Matoba Y, Sasayama S (1994) Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br Heart J 72:561–566

    Article  PubMed  CAS  Google Scholar 

  • Matsumura M, Nishioka K, Fujii T, Yoshibayashi M, Nozaki K, Nakata Y et al. (1994) Age-related acute adriamycin cardiotoxicity in mice. J Mol Cell Cardiol 26:899–905

    Article  PubMed  CAS  Google Scholar 

  • Monti E, Prosperi E, Supino R, Bottiroli G (1995) Free radical-dependent DNA lesions are involved in the delayed cardiotoxicity induced by adriamycin in the rat. Anticancer Res 15:193–198

    PubMed  CAS  Google Scholar 

  • Nysom K, Holm K, Lipsitz SR, Mone SM, Colan SD, Orav EJ et al. (1998) Relationship between cumulative Anthracycline dose and late cardiotoxicity in childhood acute lymphoblastic leukemia. J Clin Oncol 16:545–550

    PubMed  CAS  Google Scholar 

  • Pein F, Vassal G, Sakiroglu C, Tournade MF, Lemerle J (1995) Aspects pédiatriques de la toxicité cardiaque des anthracyclines et implications pratiques pour sa prévention. Arch Pédiatr 2:988–999

    Article  PubMed  CAS  Google Scholar 

  • Pihkala J, Saarinen UM, Lundström U, Virtanen K, Virkola K, Sûmes MA et al. (1996) Myocardial function in children and adolescents after therapy with anthracyclines and chest irradiation. Eur J Cancer 32 A: 97–103

    Article  Google Scholar 

  • Praet M, Ruysschaert JM (1993) In-vivo and in-vitro mitochondrial membrane damages induced in mice by adriamycin and dérivâtes. Biochem Biophys Acta 1149:79–85

    Article  PubMed  CAS  Google Scholar 

  • Praga C, Beretta G, Vigo PL, Lenaz GR, Pollini C, Bonadonna G, Canetta R et al. (1979) Adriamycin cardiotoxicity: a survey of 1273 patients. Cancer Treat Rep 63:827–834

    PubMed  CAS  Google Scholar 

  • Rowan RA, Masek MA, Billingham ME (1988) Ultrastructural morphometric analysis of endomyocardial biopsies. Idiopathic dilated cardiomyopathy, anthracycline cardiotoxicity, and normal myocardium. Am J Cardiovasc Pathol 2:137–144

    PubMed  CAS  Google Scholar 

  • Sarvazyan NA, Askari A, Huang HW (1995) Effects of doxorubicin on cardiomyocytes with reduced level of Superoxide dismutase. Life Sci 57:1003–1010

    Article  PubMed  CAS  Google Scholar 

  • Schmitt-Gräff A, Scheulen ME (1986) Prevention of Adrianycin cardiotoxicity by Niacin, isocitrate or N-acetyl-cysteine in mice. A morphological study. Path Res Pract 181:168–174

    Article  PubMed  Google Scholar 

  • Schwartz RG, McKenzie WB, Alexander J, Sager P, D’Souza A, Manatunga A et al. (1987) Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy. Seven-year experience using serial radionuclide angiocardiography. Am J Med 82:1109–1118

    Article  PubMed  CAS  Google Scholar 

  • Shan K, Lincoff AM, Young JB (1996) Anthracycline-induced cardiotoxicity. Ann Int Med 125:47–58

    Article  PubMed  CAS  Google Scholar 

  • Singal PK, Pierce GN (1986) Adriamycin stimulates low-affinity Ca++ binding and lipid peroxidation but depresses myocardial function. Am J Physiol 250: H419–H425

    PubMed  CAS  Google Scholar 

  • Singal PK, Deally CMR, Weinberg LE (1987) Subcellular effects of adriamycin in the heart: A concise review. J Mol Cell Cardiol 19:817–828

    Article  PubMed  CAS  Google Scholar 

  • Singer IW, Narahara KA, Ritchie JL, Hamilton GW, Kennedy JW (1978) Time-and dose-dependent changes in ejection fraction determined by radionuclide angiography after anthracycline therapy. Cancer Treat Rep 62:945–948

    PubMed  CAS  Google Scholar 

  • Steinherz LJ, Steinherz PG, Tan CTC, Heller G, Murphy L (1991) Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 266:1672–1677

    Article  PubMed  CAS  Google Scholar 

  • Takano H, Ozawa H, Kobayashi I, Hamaoka S, Nakajima A, Nakamura T et al. (1995) Atrophic nerve fibers in regions of reduced MIBG uptake in doxorubicin cardiomyopathy. J Nud Med 36:2060–2061

    CAS  Google Scholar 

  • Voest EE Acker SABE van van der Vijgh WJF Asbeck BS van Bast A 1994 Comparison of different iron chelators as protective agents against acute doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol 261179–1185

    Google Scholar 

  • Wakasugi S, Fischman AJ, Babich JW, Aretz HT, Callahan RJ, Nakaki M et al. (1993) Metaiodobenzylguanidine: evaluation of its potential as a tracer for monitoring doxorubicin cardiomyopathy. J Nucl Med 34:1282–1286

    Google Scholar 

  • Wortman JE, Lucas VS jr, Schuster E, Thiele D, Logue GL (1979) Sudden death during doxorubicin administration. Cancer 44:1588–1591

    Article  PubMed  CAS  Google Scholar 

  • Zorzato F, Salviati G, Facchinetti T, Vblpe P (1985) Doxorubicin induces calcium release from terminal cisternae of skeletal muscle. A study on isolated sarcoplasmic reticulum and chemically skinned fibers. J Biol Chemistry 260:7349–7355

    CAS  Google Scholar 

Kokain

  • Ascher EK, Staufer JCE, Gaasch WH (1988) Coronary artery spasm, cardiac arrest, transient electrocardiographic Q waves and stunned myocardium in cocaine-associated acute myocardial infarction. Am J Cardiol 61:939–941

    Article  PubMed  CAS  Google Scholar 

  • Ashchi M, Wiedemann HP, James KB (1955) Cardiac complication from use of cocaine and phenylephrine in nasal septoplasty. Arch Otolaryngol Head Neck Surg 121:681–684

    Article  Google Scholar 

  • Billingham ME (1991) Direct and indirect morphological markers of cocaine toxicity in the human heart. NIDA Res Momogr 108:202–219

    CAS  Google Scholar 

  • Brickner ME, Willard JE, Eichhorn EJ, Black J, Grayburn PA (1991) Left ventricular hypertrophy associated with chronic cocaine abuse. Circulation 84:1130

    Article  PubMed  CAS  Google Scholar 

  • Bunn WH, Giannini AJ (1992) Cardiovascular complications of cocaine abuse. Am Fam Physician 46:769–773

    PubMed  CAS  Google Scholar 

  • Chambers HF, Morris DL, Täuber MG, Modin G (1987) Cocaine use and the risk for endocarditis in intravenous drug users. Ann Int Med 106:833–836

    Article  PubMed  CAS  Google Scholar 

  • Chiu YC, Brecht K, DasGupta DS, Mhoon E (1986) Myocardial infarction with topical cocaine anesthesia for nasal surgery. Arch Otolaryngol Head Neck Surg 112:988–990

    Article  PubMed  CAS  Google Scholar 

  • Chokshi SK, Gal D, DeJesus S, Isner JM (1990) Cocaine produces vasoconstriction of human coronary arteries: in vitro studies using coronary arteries obtained from freshly explanted human hearts. JACC 15:215 A

    Article  Google Scholar 

  • Chokshi SK, Moore R, Pandian NG, Isner JM (1989) Reversible cardiomyopathy associated with cocaine intoxication. Ann Int Med 111:1039–1040

    Article  PubMed  CAS  Google Scholar 

  • Coleman DL, Ross TF, Naughton JL (1982) Myocardial ischemia and infarction related to recreational cocaine use. West J Med 136:444–446

    PubMed  CAS  Google Scholar 

  • Cregler LL (1991) The newest risk factor for cardiovascular disease. Clin Cardiol 14:449–456

    Article  PubMed  CAS  Google Scholar 

  • Cregler LL, Mark H (1985) Relation of acute myocardial infarction to cocaine abusers. Am J Cardiol 56:794

    Article  PubMed  CAS  Google Scholar 

  • Das G (1993) Cocaine abuse in North America: a milestone in history. J Clin Pharmacol 33:296–310

    Article  PubMed  CAS  Google Scholar 

  • Dressier FA, Malekzadeh S, Roberts WC (1990) Quantitative analysis of amounts of coronary arterial narrowing in cocaine addicts. Am J Cardiol 65:303–308

    Article  Google Scholar 

  • Fenoglio JJ, McAllister HA, Mullick FG (1981) Drug related myocarditis. I. Hypersensitivity myocarditis. Hum Pathol 12:900–907

    Article  PubMed  Google Scholar 

  • Flores ED, Lange RA, Cigarroa RG, Hillis LD (1990) Effect of cocaine on coronary artery dimensions in atherosclerotic coronary artery disease: enhanced vasoconstriction at site of significant stenoses. JACC 16:74–79

    Article  PubMed  CAS  Google Scholar 

  • Fraker TD jr, Temesy-Armos PN, Brewster PS, Wilkerson RD (1990) Mechanism of cocaine-induced myocardial depression in dogs. Circulation 81:1012–1016

    Article  PubMed  CAS  Google Scholar 

  • Gardin JM, Wong N, Alker K, Hale SL, Paynter J, Knoll M et al. (1994) Acute cocaine administration induces ventricular regional wall motion and ultrastructural abnormalities in an anesthetized rabbit model. Am Heart J 128:1117–1129

    Article  PubMed  CAS  Google Scholar 

  • Gould L, Gopalaswamy C, Patel C, Betzu R (1985) Cocaine-induced myocardial infarction. NY State J Med 85:660–661

    CAS  Google Scholar 

  • Hale SL, Alker KJ, Rezkalla S, Figures G, Kloner RA (1989) Adverse effects of cocaine on cardiovascular dynamics, myocardial blood flow, and coronary diameter in an experimental model. Am Heart J 118:927–933

    Article  PubMed  CAS  Google Scholar 

  • Hayes SN, Moyer TP, Morley D, Bove A A (1991) Intravenous cocaine causes epicardial coronary vasoconstriction in the intact dog. Am Heart J 121:1639–1648

    Article  PubMed  CAS  Google Scholar 

  • Heesch CM, Negus BH, Steiner M, Snyder RW, Mclntire DD, Grayburn PA et al. (1996) Effects of in vivo cocaine administration on human platelet aggregation. Am J Cardiol 78:237–239

    PubMed  CAS  Google Scholar 

  • Hollander JE, Hoffman RS, Burstein JL, Shih RD, Thode HC jr (1995) Cocaine-associated myocardial infarction. Mortality and complications. Arch Intern Med 155:1081–1086

    Article  PubMed  CAS  Google Scholar 

  • Howard RE, Hueter DC, Davis GJ (1985) Acute myocardial infarction following cocaine abuse in a young woman with normal coronary arteries. JAMA 254:95–96

    Article  PubMed  CAS  Google Scholar 

  • Isner JM, Chokshi SK (1989) Cocaine and vasospasm. N Engl J Med 321:1604–1606

    Article  PubMed  CAS  Google Scholar 

  • Isner JM, Chokshi SK (1991) Cardiac complications of cocaine abuse. Annu Rev Med 42:133–138

    Article  PubMed  CAS  Google Scholar 

  • Isner JM, Estes NAM, Thompson PD, Costanzo-Nordin MR, Subramanian R et al. (1986) Acute cardiac events temporally related to cocaine abuse. N Engl J Med 315:1438–1443

    Article  PubMed  CAS  Google Scholar 

  • Kaplan M, Glaser J (1996) Fetal myocardial calcification associated with maternal cocaine use (letter). Am J Perinatol 13:67

    Article  PubMed  CAS  Google Scholar 

  • Karch SB, Billingham ME (1986) Myocardial contraction bands revisted. Hum Pathol 17:9–13

    Article  PubMed  CAS  Google Scholar 

  • Karch SB, Billingham ME (1995) Coronary artery and peripheral vascular disease in cocaine users. Coronary Artery Dis 6:220–225

    CAS  Google Scholar 

  • Karch SB, Green S, Young S (1995) Myocardial hypertrophy and coronary artery disease in male cocaine users. J Forens Sci 40:591–595

    CAS  Google Scholar 

  • Keegan A (1991) Cocaine plus alcohol. A deadly mix. NIDA Notes 6:18–19

    Google Scholar 

  • Kloner RA, Hale S, Alker K, Rezkalla S (1992) The effects of acute and chronic cocaine use on the heart. Circulation 85:407–419

    Article  PubMed  CAS  Google Scholar 

  • Kolodgie FD, Farb A, Virmani R (1995) Pathobiological determinants of cocaine-associated cardiovascular syndromes. Hum Pathol 26:583–586

    Article  PubMed  CAS  Google Scholar 

  • Kolodgie FD, Virmani R, Cornhill JF, Herderick EE, Malcolm GT, Mergner WJ (1992) Cocaine. An independent risk factor for aortic sudanophilia. A preliminary report. Atherosclerosis 97:53–62

    Article  PubMed  CAS  Google Scholar 

  • Kolodgie FD, Virmani R, Cornhill JF, Herderick EE, Smialek J (1991) Increase in atherosclerosis and adventitial mast cells in cocaine abusers: an alternative mechanism of cocaine-associated coronary vasospasm and thrombosis. JACC 17:1553–1560

    Article  PubMed  CAS  Google Scholar 

  • Kossowsky WA, Lyon AF (1984) Cocaine and acute myocardial infarction. A probale connection. Chest 86:729–731

    Article  PubMed  CAS  Google Scholar 

  • Lange RA, Cigarroa RG, Yancy CW jr, Willard JE, Popma JJ, Sils MN et al. (1989) Cocaine-induced coronary artera vasoconstriction. N Engl J Med 321:1557–1562

    Article  PubMed  CAS  Google Scholar 

  • Lange RA, Cigarroa RG, Flores EC, McBride W, Kim AS, Wells PJ et al. (1990) Potentiation of cocaineinduced vasoconstriction by beta-adrenergic blockade. Ann Intern Med 112 1897–903

    Article  Google Scholar 

  • Leune J (1995) Illegale Drogen in der Gesellschaft. In: Hüllinghorst R, Brockhoff V, Lindemann F (Hrsg) Jahrbuch Sucht 1995. Neuland, Geesthacht, S 115–124

    Google Scholar 

  • Majid PA, Patel B, Kim HS, Zimmermann JL, Dellinger RP (1990) An angiographie and histiologic study of cocaine-induce chest pain. Am J Cardiol 65:812–814

    Article  PubMed  CAS  Google Scholar 

  • Mehta SK, Finkelhor RS, Anderson RL, Harcar-Sevc KRA, Wasser TE, Bahler RC (1993) Transient myocardial ischemia in infants prenatally exposed to cocaine. J Pediatr 122:945–994

    Article  PubMed  CAS  Google Scholar 

  • Minor RL, Scott BD, Brown DD, Winniford MD (1991) Cocaine-induced myocardial infarction in patients with normal coronary arteries. Ann Int Med 1151:797–806

    Google Scholar 

  • Mittleman RE, Wetli CV (1987) Cocaine and sudden “natural” death. J Forensic Sci 32:11–19

    PubMed  CAS  Google Scholar 

  • Mouhaffel AH, Madu EC, Satmary WA, Fraker TD (1995) Cardiovascular complications of cocaine. Chest 107:1426–1434

    Article  PubMed  CAS  Google Scholar 

  • Om A, Warner M, Sabri N, Cecich L, Vetrovec G (1992) Frequency of coronary artery disease and left ventricular dsyfunction in cocaine users. Am J Cardiol 69:1549–1552

    Article  PubMed  CAS  Google Scholar 

  • Orr D, Jones I (1968) Anaesthesia for laryngoscopy. A comparison of the cardiovascular effects of cocaine and lignocaine. Anaesthesia 23:194–202

    Article  PubMed  CAS  Google Scholar 

  • Pasternak PF, Colvin SB, Baumann FG (1985) Cocaine-induced angina pectoris and acute myocardial infarction in patients younger than 40 years. Am J Cardiol 55:847

    Article  Google Scholar 

  • Peng SK, French WJ, Pelikan PCD (1989) Direct cocaine cardiotoxicity demonstrated by endomyocardial biopsy. Arch Pathol Lab Med 113:842–845

    PubMed  CAS  Google Scholar 

  • Rashid J, Eisenberg MJ, Topol EJ (1996) Cocaine-induced aortic dissection. Am Heart J 132: 1301–1304

    Article  PubMed  CAS  Google Scholar 

  • Rauschgiftjahresbericht (1993) Bundeskriminalamt Wiesbaden, Abteilung Rauschgiftbekämpfung. In: Hüllinghorst R, Brockhoff V, Lindemann F (Hrsg) Jahrbuch Sucht 1995. Neuland, Geesthacht, S 93–114

    Google Scholar 

  • Rezkalla SH, Hale S, Kloner RA (1990) Cocaine-induced heart diseases. Am Heart J 120:1403–1408

    Article  PubMed  CAS  Google Scholar 

  • Rongione AJ, Steg PG, Gal D, Isner JM (1988) Cocaine causes endothelium-independent vasoconstriction of vascular smooth muscle. Circulation 78(Suppl II):II–436

    Google Scholar 

  • Rump AFE, Theisohn M, Klaus W (1995) The pathophysiology of cocaine cardiotoxicity. Forens Sei Internat 71:103–115

    Article  CAS  Google Scholar 

  • Schachne JS, Roberts BH, Thompson PD (1984) Coronary-artery spasm and myocardial infarction associated with cocaine use. N Engl J Med 310:1655–1656

    Google Scholar 

  • Simkhovich BZ, Kloner RA, Alker KJ, Giaconi JA (1994) Time course of direct cardiotoxic effects of high cocaine concentration in isolated rabbit heart. J Cardiovasc Pharm 23:509–516

    CAS  Google Scholar 

  • Simpson RW, Edwards WD (1986) Pathogenesis of cocaine-induced ischémie heart disease: Autopsy findings in a 21-year-old-man. Arch Pathol Lab Med 110:479–484

    PubMed  CAS  Google Scholar 

  • Smith HWB, Liberman HA, Brody SL, Battey LL, Donohue BC, Morris DC (1987) Acute myocardial infarction temporally related to cocaine use. Clinical, angiographie, and pathophysiologic observations. Ann Intern Med 107:13–18

    Article  PubMed  Google Scholar 

  • Stenberg RG, Winniford MD, Hillis LD, Dowling GP, Buja LM (1989) Simultaneous acute thrombosis of two major coronary arteries following intravenous cocaine use. Arch Pathol Lab Med 113:521–524

    PubMed  CAS  Google Scholar 

  • Suttliff RL, Cai G, Gurdal H, Snyder DL, Roberts J, Johnson MD (1996) Cardiovascular hypertrophy and increased vascular contractile responsiveness following repeated cocaine administration in rabbits. Life Sci 58:675–682

    Article  Google Scholar 

  • Tazelaar HD, Karch SB, Stephens BG, Billingham ME (1987) Cocaine and the heart. Hum Pathol 18:195–199

    Article  PubMed  CAS  Google Scholar 

  • Vincent GM, Anderson JL, Marshall HW (1983) Coronary spasm producing coronary thrombosis and myocardial infarction. N Engl J Med 309:2120–2123

    Article  Google Scholar 

  • Virmani R, Robinowitz M, Smialek JE, Smyth DF (1988) Cardiovascular effects of cocaine: an autopsy study of 40 patients. Am Heart J 115:1068–1076

    Article  PubMed  CAS  Google Scholar 

  • Vitullo JC, Karam R, Mekhail N, Wicker P, Engelmann GL, Khairallah PA (1989) Cocaine-induced small vessel spasm in isolated rat hearts. Am J Pathol 135:85–91

    PubMed  CAS  Google Scholar 

  • Weiss RJ (1986) Recurrent myocardial infarction caused by cocaine abuse. Am Heart J 111:793

    Article  PubMed  CAS  Google Scholar 

  • Wiener RS, Lockhart JT, Schwartz RG (1986) Dilated cardiomyopathy and cocaine abuse. Report of two cases. Am J Med 81:699–701

    Article  PubMed  CAS  Google Scholar 

  • Wilbert-Lampen U, Seliger C, Zilker T, Arendt RA (1997) Untersuchungen zum Mechanismus Cocain-induzierter Vasospasmen. Z Kardiol 86(Suppl 2): 118

    Google Scholar 

  • Yap TE, Diana D, Herson V, Chameides L, Rowe JC (1994) Fetal myocardial calcification associated with maternal cocaine use. Am J Perinatol 11:179–183

    Article  PubMed  CAS  Google Scholar 

  • Young D, Glauber JJ (1947) Electrocardiographic changes resulting from acute cocaine intoxication. Am Heart J 34:272–279

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann FH, Gustafson GM, Kemp HG (1987) Recurrent myocardial infarction associated with cocaine abuse in a young man with normal coronary arteries: evidence for coronary artery spasm culminating in thrombosis. JACC 9:964–968

    Article  Google Scholar 

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  1. H. Frenzel
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  1. Pathologisches Institut der Heinrich-Heine-Universität, Moorenstrasse 5, 40225, Düsseldorf, Germany

    Waldemar Hort

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Frenzel, H., Schwartzkopff, B., Hort, W. (2000). Toxische Schäden des Herzens durch Alkohol, Anthrazykline und Kokain. In: Hort, W. (eds) Pathologie des Endokard, der Kranzarterien und des Myokard. Spezielle pathologische Anatomie, vol 22 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56944-9_9

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