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Pathology of Asbestos-Associated Diseases pp 215–251Cite as

Experimental Models of Asbestos-Related Diseases

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Abstract

Much of our understanding of the mechanisms by which asbestos injures the lung has been derived from experimental animal studies. Such studies have confirmed the fibrogenic and carcinogenic properties of asbestos fibers that have been surmised from human observations and have provided insights into the ways in which asbestos fibers interact with biological systems. Models commonly used to study asbestos-induced disease involve inhalation exposure to asbestos, intratracheal instillation, and in vitro studies of various cellular systems. Each of these techniques has particular advantages and disadvantages.

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Authors and Affiliations

  1. Department of Medicine, Brigham & Womens Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Judson M. Englert MD, PhD & Corrine R. Kliment MD, PhD

  2. Department of Pathology, University of Pittsburgh, W-952 BST 200 Lothrop Street, Pittsburgh, PA, 15261, USA

    Tim D. Oury MD, PhD

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  1. University of Pittsburgh Dept. Pathology, Pittsburgh, Pennsylvania, USA

    Tim D. Oury

  2. Duke University Medical Center Dept. Pathology, Durham, North Carolina, USA

    Thomas A. Sporn

  3. Duke University Medical Center Dept. Pathology, Durham, North Carolina, USA

    Victor L. Roggli

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Englert, J.M., Kliment, C.R., Oury, T.D. (2014). Experimental Models of Asbestos-Related Diseases. In: Oury, T., Sporn, T., Roggli, V. (eds) Pathology of Asbestos-Associated Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41193-9_10

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