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Thyroid and Parathyroid Tumors

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Pediatric Surgery
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Abstract

Thyroid and parathyroid tumors are rare in children. The most common types are papillary and follicular carcinoma, collectively referred to as differentiated thyroid cancer (DTC). Compared to adults, children with DTC typically present with more advanced disease but they have an excellent prognosis with a high cure rate and low risk of death, at least in the short-term. Current treatment recommendations are based largely on adult data supplemented by a small number of pediatric reports. This treatment consists of total thyroidectomy for DTC followed in most cases by radioactive I131 for remnant ablation and control of residual occult local and metastatic disease. Long-term follow-up is mandatory.

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References

  • Ahn HS, Kim HJ, Welch HG. Korea’s thyroid-cancer epidemic – screening and overdiagnosis. N Engl J Med. 2014;371:1765–7.

    Article  Google Scholar 

  • Arenas MR, Morris L, Rich T, Cote G, Grubbs E, et al. Preoperative multiple endocrine neoplasia type 1 diagnosis improves the outcomes of pediatric patients with primary hyperparathyroidism. J Pediatr Surg. 2014;49:546–50.

    Article  Google Scholar 

  • Bhatti P, Veiga L, Ronckers CM, Sigurdson AJ, Stovall M, et al. Risk of second primary thyroid cancer after radiotherapy for a childhood cancer in a large cohort study: an update from the childhood cancer survivor study. Radiat Res. 2010;174(6):741–52.

    Article  CAS  Google Scholar 

  • Breuer C, Tuggle C, Solomon D, Sosa JA. Pediatric thyroid disease: when is surgery necessary, and who should be operating on our children? J Clin Res Pediatr Endocrinol. 2013;5(1):S79–85.

    Google Scholar 

  • Chen AY, Davies L. Children and thyroid cancer: interpreting troubling trends. Cancer. 2019;125(14):2359–61.

    Article  Google Scholar 

  • Cibas E, Ali S. The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol. 2009;132(5):658–65.

    Article  Google Scholar 

  • Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19(11):1167–214.

    Article  Google Scholar 

  • Corrias A, Mussa A. Thyroid nodules in pediatrics: which ones can be left alone, which ones must be investigated, when and how. J Clin Res Pediatr Endocrinol. 2013;5(Suppl 1):57–69.

    Google Scholar 

  • Detweiler K, Elfenbein DM, Mayers D. Evaluation of thyroid nodules. Surg Clin North Am. 2019;99(4):571–86.

    Article  Google Scholar 

  • Diller L, Chow EJ, Gurney JG, Hudson MM, et al. Chronic disease in the childhood cancer survivor study cohort: a review of published findings. J Clin Oncol. 2009;27(14):2339–55.

    Article  Google Scholar 

  • Enomoto Y, Enomoto K, Uchino S, Shibuya H, Watanabe S, et al. Clinical features, treatment, and long-term outcome of papillary cancer in children and adolescents without radiation exposure. World J Surg. 2012;36(6):1241–6.

    Article  Google Scholar 

  • Gonzalez-Gonzalez R, Bologna-Molina R, Carreon-Burciaga RG, Gómezpalacio-Gastelum M, Molina-Frechero N, et al. Papillary thyroid carcinoma: differential diagnosis and prognostic values of its different variants: review of the literature. ISRN Oncol. 2011;2011:915925.

    PubMed  PubMed Central  Google Scholar 

  • Grogan R, Kaplan S, Cao H, Weiss R, DeGroot L, et al. A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up. Surgery. 2013;154(6):1436–47.

    Article  Google Scholar 

  • Hogan A, Zhuge Y, Perez E, Koniaris L, Lew J, Sola J, et al. Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients. J Surg Res. 2009;156(1):167–72.

    Article  Google Scholar 

  • Holmes L, Hossain J, Opara F. Pediatric thyroid carcinoma incidence and temporal trends in the USA (1973–2007): race or shifting diagnostic paradigm? ISRN Oncol. 2012; 906197.

    Google Scholar 

  • La Franchi S. Thyroid nodules and cancer in children. 2013. http://www.uptodate.com/contents/thyroid-nodules-and-cancer-in-children

  • Lodish MB, Stratakis CA. RET oncogene in MEN2, MEN2B, MTC, and other forms of thyroid cancer: molecular genetics and therapeutic advances. Expert Rev Anticancer Ther. 2008;8(4):625–32.

    Article  CAS  Google Scholar 

  • Park S, Jeong JS, Ryu HR, Lee CR, Park JH, et al. Differentiated thyroid carcinoma of children and adolescents: 27-year experience in the Yonsei University health system. J Korean Med Sci. 2013;28(5):693–9.

    Article  CAS  Google Scholar 

  • Paulson VA, Rudzinski ER Hawkins DS. Thyroid cancer in the pediatric population. Genes (Basel). 2019;10(9):pii: E723.

    Google Scholar 

  • Rivkees SA, Mazzaferri EL, Verburg FA, Reiners C, Luster M, et al. The treatment of differentiated thyroid cancer in children: emphasis on surgical approach and radioactive iodine therapy. Endocr Rev. 2011;32(6):798–826.

    Article  CAS  Google Scholar 

  • Robison LL. Treatment-associated subsequent neoplasms among long-term survivors of childhood cancer: the childhood cancer survivor study experience. Pediatr Radiol. 2009;39(1):S32–7.

    Article  Google Scholar 

  • Tavares MR, Toledo S, Montenegro FL, Moyses RA, Toledo RA, et al. Surgical approach to medullary thyroid carcinoma associated with multiple endocrine neoplasia type 2. Clinics. 2012;67(Suppl 1):149–54.

    Article  Google Scholar 

  • Vaisman F, Corbo R, Vaisman M. Thyroid carcinoma in children and adolescents—systematic review of the literature. J Thyroid Res. 2011;2011:845362.

    Article  Google Scholar 

  • Veiga L, Bhatti P, Ronckers CM, Sigurdson AJ, Stovall M, et al. Chemotherapy and thyroid cancer risk: a report from the childhood cancer survivor study. Cancer Epidemiol Biomark Prev. 2012;21(1):92–101.

    Article  CAS  Google Scholar 

  • Yim Y, Baek JH. Core needle biopsy in the management of thyroid nodules with an indeterminate fine-needle aspiration report. Gland Surg. 2019;8(Suppl 2):S77–85.

    Article  Google Scholar 

  • Yu Q, Liu K, Ma D, et al. Do symptoms and serum calcium levels affect the results of surgical treatment of primary hyperparathyroidism? Biomed Res Int. 2019;2019:2150159.

    PubMed  PubMed Central  Google Scholar 

  • Yunker WK, Hassan SF, Ferrell LB, et al. Needle core biopsy in the diagnosis of pediatric thyroid neoplasms: a single institution retrospective review. Pediatr Surg Int. 2013;29(5):437–43.

    Article  CAS  Google Scholar 

  • Zablotska LB, Ron E, Rozhko AV, Hatch M, Polyanskaya ON, et al. Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chernobyl accident. Br J Cancer. 2011;104(1):181–7.

    Article  CAS  Google Scholar 

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Correspondence to David E. Wesson .

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Wesson, D.E. (2020). Thyroid and Parathyroid Tumors. In: Puri, P. (eds) Pediatric Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38482-0_158-1

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  • DOI: https://doi.org/10.1007/978-3-642-38482-0_158-1

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  • Print ISBN: 978-3-642-38482-0

  • Online ISBN: 978-3-642-38482-0

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